suppresse – Page 3 – Communicable Diseases Research

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

Perspective

Published on 2022-01-142022-10-28
Journal: Pathogens [Category] COVID-19,

SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry

423

Published on 2022-01-132022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

'SARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제한다'는 논평에 대한 응답

Comment

Published on 2022-01-112022-09-10
Journal: eLife [Category] SARS, 유전자 메커니즘,

Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

'SARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제한다'에 대한 논평

Comment

Published on 2022-01-112022-09-10
Journal: eLife [Category] SARS, 유전자 메커니즘,

[키워드] Analysis analyzed Anticoagulant asthmatic BALF Bronchoalveolar lavage fluid Coagulation coagulation cascade Coagulopathies Comment comparable Complete COVID-19 COVID-19 patient COVID-19 patients data set data sets dataset datasets expression extrinsic Factor FIBRIN fibrinogen fibrinolysis fibrinolytic Gene Expression Human increases in Inflammatory inhibitor Interaction Local Lungs master regulator mechanism Microbiome mRNA expression obese performed protein C reduced remained reported Retrospective analysis RNA-Seq RNA-sequencing SARS-CoV-2 significantly supported suppresse TFPI These data Tissue Factor Transcriptome transcriptomic analysis upregulation
[DOI] 10.7554/eLife.74268 PMC 바로가기 [Article Type] Comment

Immunoediting in SARS-CoV-2: Mutual relationship between the virus and the host

Review

Published on 2022-01-102022-10-04
Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 치료기술,

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

SARS-CoV-2 ORF10은 미토파지를 통해 MAVS를 분해하여 항바이러스 선천 면역 반응을 억제합니다.

Article

Published on 2022-01-012022-09-11
Journal: Cellular and Molecular Immunology [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] accumulation Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral signaling autophagy binding blocked caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Degradation expressed expression facilitated Frame humans IFN-I IFN-I signaling IFN-stimulated genes induce inhibit inhibited innate immune innate immune response Interaction knockdown MAVS mechanism Mitochondria mitochondrial mitophagy. morbidity and mortality NIX Open reading frame ORF10 overexpression pandemic pathway promoted Protein receptor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus suppresse suppressed target translocated type I interferon viral genes viral replication
[DOI] 10.1038/s41423-021-00807-4 PMC 바로가기 [Article Type] Article

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

NLRP3 인플라마좀의 특정 억제는 면역 과잉 활성화를 억제하고 생쥐의 병리와 같은 COVID-19를 완화합니다

Article

Published on 2021-12-312022-09-11
Journal: EBioMedicine [Category] SARS, 유전자 메커니즘, 진단,

[키워드] activated Activation advance alleviate biosafety level BSL-3 Bureau C57BL/6 CAS Cell culture cell cultures conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 severity Cytokines education Evidence finding funding global public health histological host gene Host immune response human ACE2 immune immunofluorescence analysis immunopathology indicated inhibition inhibitor injected Intervention intranasally intraperitoneally Invasion involved knockout mice Laboratory level 3 live SARS-CoV-2 Lung inflammation lung tissue lung tissues Lungs macrophages MCC950 mice NLRP3 NLRP3 inflammasome pandemic pathology performed pro-inflammatory cytokine pro-inflammatory cytokines Program provided quantitative real-time PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, NLRP3 inflammasome, Immune overactivation, Cytokine storm Science severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe pathology severity Specific supported suppresse targeting THP-1 tissues transgenic mice Vaccine development Viral was reduced West wild-type with COVID-19
[DOI] 10.1016/j.ebiom.2021.103803 PMC 바로가기 [Article Type] Article

Evolution of enhanced innate immune evasion by SARS-CoV-2

SARS-CoV-2에 의한 강화된 타고난 면역 회피의 진화

Article

Published on 2021-12-232022-09-10
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료법,

[키워드] Activation adaptation airway airway epithelial cell airway epithelial cells Alpha Alpha variant antagonists assays association B.1.1.7 changes in characterization coding region contribute Delta Duration of infection effective effort ENhance epithelial cells expression first-wave Human human-to-human transmission immune responses increase increase in innate immune innate immune response innate immune responses Interaction isolate isolates lead likelihood MAVS mitochondrial Mutation nucleocapsid protein observation omicron ORF6 Orf9b Phosphoproteomics Phosphorylation Protein protein level protein levels Proteins proteomics regulated regulatory region Replication required RNA RNA sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein suppress suppresse suppressed Systems biology the spike protein Transmission upregulation variant variants variants of concern Viral viral adaptation viral replication
[DOI] 10.1038/s41586-021-04352-y PMC 바로가기 [Article Type] Article

Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution

Review

Published on 2021-12-142022-10-28
Journal: Biomolecules [Category] COVID-19, SARS,

Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues

자가포식 억제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스 및 이종이식 인간 폐 조직에서 폐렴을 개선합니다

Article

Published on 2021-11-232022-09-11
Journal: Journal of Virology [Category] SARS, 유전자 메커니즘,

[키워드] 3-MA accompanied Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin animal model animal models anti-SARS-CoV-2 therapeutics Atg13 ATG14 Atg5 autophagic autophagy autophagy-inhibiting agent autophagy-inhibiting agents block caused Combination complex complexes contribute coronavirus Crab-eating macaque Critical elements enzyme events experimental evidence global pandemic hACE2 Huh-7 cells Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung human lung tissue IMPROVE in vitro in vivo induce Infection inhibit inhibition insight interfere involved mechanism mice modulation mouse mTOR pathway Pneumonia potential therapeutic target potential therapeutic targets SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppresse therapeutic agent therapeutic agents thought tissues transgenic mice Transgenic mouse Vero E6 virus infection Virus-host interaction Virus-host interactions Vps34
[DOI] 10.1128/JVI.01537-21 PMC 바로가기 [Article Type] Article