Surface glycoprotein – Page 3 – Communicable Diseases Research

Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations

우성 돌연변이가 있거나 없는 SARS-CoV-2 게놈 간의 S 및 RdRp의 다른 선택 역학

Article

Published on 2021-07-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종,

How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?

Review

Published on 2021-06-252022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Article

Published on 2021-06-162022-11-01
Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS,

[키워드] adaptive cause convalescent COVID‐19 COVID‐19 patient COVID‐19 patients Epigenetic gene expression signature healthy hyperinflammation Hyperinflammatory syndrome Immunity immunology in vivo Inflammasome inflammasome activation Innate innate immune innate immune memory Innate immunity longitudinal analysis Macrophage Microbiology, Virology & Host Pathogen Interaction Modification monocyte naïve individuals NLRP3 patients responsible resulting robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 secretion Signaling Spike protein subset Surface glycoprotein transcriptional Trigger vaccine antigen viral control
[DOI] 10.15252/emmm.202114150 PMC 바로가기 [Article Type] Article

SARS-CoV-2 vaccines: a triumph of science and collaboration

SARS-CoV-2 백신: 과학과 협력의 승리

Review

Published on 2021-05-102022-09-10
Journal: JCI Insight [Category] SARS, 변종, 임상,

Host barriers to SARS-CoV-2 demonstrated by ferrets in a high-exposure domestic setting

높은 노출 국내 환경에서 흰 족제비에 의해 입증 된 SARS-CoV-2에 대한 호스트 장벽

423

Published on 2021-05-042022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Angiotensin-converting enzyme Antibody assays barrier circulating cleavage Contact coronavirus COVID-19 decrease demonstrated direct contact discrepancy Effect Efficiency environmental exposure Evidence evidence of experiment exposure to Factor ferret ferrets furin Genetic genetic factors genetics Host host adaptation hosts Human hypothese idea Infection Laboratory limit Mutation natural experiment natural infection no evidence of onward transmission positive predicted provide raising respiratory respiratory virus respiratory viruses risk S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 susceptibility SARS-CoV-2 transmission second sequence severe acute respiratory syndrome Coronavirus shown Significance spike Support Surface glycoprotein susceptible symptomatic symptomatic COVID-19 symptomatic disease These data Transmission Viral viral adaptation Virology virus viruses while
[DOI] 10.1073/pnas.2025601118 PMC 바로가기 [Article Type] 423

50 Years of structural immunology

JBC Reviews

Published on 2021-05-032022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19,

[키워드] adaptive antibodies antibody Antigen antigens build CDR, complementarity-determining region cellular cellular immunity CoV, coronavirus cytokine engage EPO, erythropoietin EPOR, erythropoietin receptor equivalent example explained germline gene GP, glycoprotein HA, hemagglutinin hGH, human growth hormone host cell Humoral immunity Ig, immunoglobulin immune recognition immune response immune system Immunity immunological immunology include Inflammation information inherent innate immune system lipids MHC MHC molecule MHC, major histocompatibility complex microbial microbial pathogens momentum MR, molecular replacement Mutation NA, neuraminidase NKT cell, natural killer T cell NTD, N-terminal domain nucleic acids pathogen PDB, Protein Data Bank peptide processed Protein protein antigen Proteins RBD, receptor-binding domain receptor receptors recognize Recombination regulate RSV, respiratory syncytial virus SARS-CoV-2 Small molecules specificity Structure Surface glycoprotein T cell receptors T cells target TCR, T cell receptor the antibody response TLR TLR, Toll-like receptor Vaccine viral antigens virus VLR VLR, variable lymphocyte receptor
[DOI] 10.1016/j.jbc.2021.100745 PMC 바로가기 [Article Type] JBC Reviews

Neutralizing antibodies targeting the SARS-CoV-2 receptor binding domain isolated from a naïve human antibody library

순수 인간 항체 라이브러리에서 분리된 SARS-CoV-2 수용체 결합 도메인을 표적으로 하는 중화 항체

Article

Published on 2021-04-012022-09-12
Journal: Protein Science : A Publication of the Protein Soc [Category] MERS, SARS, 진단,

Immunoinformatic approach to design a multiepitope vaccine targeting non-mutational hotspot regions of structural and non-structural proteins of the SARS CoV2

Bioinformatics

Published on 2021-03-232022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] 3D structure Analysis Antigen antigen processing antigenicity approach B cell binding affinity binding energy calculated caused Cell complex coronavirus 2 cross-reactivity database demonstrated docking envelope protein epitope Epitopes evaluated Extracellular high mortality HLA host cell hotspot IFN immune response Immune simulation induce Infection injection interacting residue Interaction leukocyte linker MDs Membrane proteins memory Microbiome Molecular dynamics simulation morbidity multiepitope vaccine Mutation mutations non-structural protein ORF1ab polyprotein ORF3a protein ORF8 protein outbreak pandemic Physicochemical properties predicted Protein proteomics Region respiratory Result SARS CoV2 screened selected sensitivity Seven similarity strong immune response Study design Surface glycoprotein T cell the vaccine TLR TLRs Toll-like receptor Toxicity vaccination Vaccine vaccine construct virus was performed
[DOI] 10.7717/peerj.11126 PMC 바로가기 [Article Type] Bioinformatics

A cross-neutralizing antibody between HIV-1 and influenza virus

Research Article

Published on 2021-03-222022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] Analysis antibodies antibody Antigen antigenic evolution approaches Cluster compose Comprehensive conserved cross-neutralizing envelope envelope protein epitope Evolution glycan glycans glycosylated glycosylation site H3N2 H3N2 strain HIV-1 immune response immunogenic influenza hemagglutinin Influenza virus Isolation N -glycosylation negative-stain electron microscopy neutralize neutralizing antibody pandemic Patient persistence Protein provided RBS receptor binding site required Seasonal influenza Spread Strains sugars Surface glycoprotein survival target Vaccines viral pathogens viral surface virus viruses
[DOI] 10.1371/journal.ppat.1009407 PMC 바로가기 [Article Type] Research Article

An Overview of Spike Surface Glycoprotein in Severe Acute Respiratory Syndrome–Coronavirus

Molecular Biosciences

Published on 2021-03-162022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] antiviral drug binding China cleaved contagious Corona coronavirus CoV COVID-19 disease drug design ENCODE entry inhibitors envelope protein enzyme Genetic Genome highest Host host cell host cell receptor include inhibit inhibitor initial involved membrane protein MERS monomer mortality rate non-structural protein non-structural proteins Novel coronavirus nucleocapsid protein predominant protease researcher respiratory S1 and S2 S1 domain S1/S2 S2 domain SARS-CoV-2 shown small molecule spike spike (S) glycoprotein structural protein structural proteins subunit surface Surface glycoprotein target the S protein the WHO therapeutic treat Treatment Vaccine viral genome viral infection viral infections virulent virus
[DOI] 10.3389/fmolb.2021.637550 PMC 바로가기 [Article Type] Molecular Biosciences