A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryTMPRSS2 발현을 위한 고처리량 스크린으로 SARS-CoV-2 진입을 제한할 수 있는 FDA 승인 화합물 식별Article Published on 2021-06-232022-09-10 Journal: Nature Communications [Category] MERS, SARS, 비임상, [키워드] 2019-nCoV ACE2 breath Cell cell entry cell surface receptor clinical trial Compound compounds Concentration concentrations coronavirus COVID-19 disease COVID-19 infection DCAF1 DDB1 Degradation dependent on drug E3 ubiquitin ligase Effect entry of SARS-CoV-2 epithelial cells expression global pandemic halofuginone help High-throughput screening homoharringtonine Host host protease host proteases human clinical trial human clinical trials Human plasma identify in vitro library limit lung epithelial cell modulate pathogenic coronavirus pharmacokinetic data proteasome Protein reduce reducing responsible SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 glycoprotein SARS-COV-2 infection Screen Serine serine protease serine protease TMPRSS2 small molecule Small molecules spike stability surface expression surface receptor the cell TMPRSS2 TMPRSS2 expression TMPRSS2 level TMPRSS2 levels TMPRSS2 protein [DOI] 10.1038/s41467-021-24156-y PMC 바로가기 [Article Type] Article
Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung CancerMolecular Biosciences Published on 2021-06-112022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 binding binding affinity blocked caused Cell coronavirus disease COVID-19 derivative derivatives effective expression G614 mutant G614 variant global public health heparan sulfate higher infectivity host cell host cell surface host cells Increased infect Infection Interaction lung cancer lung cancer patient mechanism motifs mutant pseudovirus required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein spike Spike protein sulfate Support surface receptor the SARS-CoV-2 Treatment upregulated virus [DOI] 10.3389/fmolb.2021.649575 PMC 바로가기 [Article Type] Molecular Biosciences
Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infectionResearch Paper Published on 2021-05-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] ACE2 analyzed angiotensin-converting enzyme 2 animal models cause Cell Cerebrovascular disease chronic disease circulating Concentration Coronary heart disease coronavirus disease coronavirus spike protein COVID-19 diabetes Diabetes Mellitus diabetics drug enzyme healthy control high risk Human plasma hyperglycemia hypertension hypoglycemia increase increased risk infected with SARS-CoV-2 Infection Inflammation investigated medical record much lower obesity Patient patients with diabete plasma poor prognosis protective effect recognize recruited risk severe COVID-19 Severe COVID-19 Infection severe SARS-CoV-2 subject surface receptor susceptible [DOI] 10.18632/aging.202967 PMC 바로가기 [Article Type] Research Paper
Cardiovascular Impacts on COVID-19 Infected PatientsCardiovascular Medicine Published on 2021-05-132022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Abnormalities abnormality ACE2 Administered affected angiotensin-converting enzyme 2 Arrhythmias binding site cardiovascular Cardiovascular Abnormalities cardiovascular condition cardiovascular diseases cardiovascular risk factors cardiovascular system category Cell cell injury clinically Coagulation COVID-19 COVID-19 virus Direct drug Endothelial cell heart failure Impact include Infection Inflammation lung mechanism Myocardial myocardial injury myocarditis organ over Primary infection Protein regulate replication mechanism reported Respiratory system risk factor SARS-CoV-2 SARS-CoV-2 virus Severe Acute Respiratory Syndrome Corona Virus 2 surface receptor Symptomatic treatment target the patient therapy tissue damage viral infection viral replication viral spike with COVID-19 [DOI] 10.3389/fcvm.2021.670659 PMC 바로가기 [Article Type] Cardiovascular Medicine
Antiviral and Anti‐Inflammatory Treatment with Multifunctional Alveolar Macrophage‐Like Nanoparticles in a Surrogate Mouse Model of COVID‐19Full Paper Published on 2021-05-122022-10-28 Journal: Advanced Science [Category] COVID-19, [키워드] acting aggregation‐induced emission derivative alveolar Antiviral antiviral efficiency applied biomimetic nanoparticles caused clinical clinically coronavirus coronavirus disease COVID‐19 COVID‐19 cytokine cytokine absorption cytokine levels decrease early stage ENhance facilitate host cell inactivation Infection Inflammation lung damage Macrophage management Medicine membranes mice Model mouse multifunctional multimodal therapy murine nanoparticle neutralization pandemic photothermal inactivation progression Proinflammatory cytokine proinflammatory cytokines receptor receptors reduce reducing regimen regimens reported respiratory tract risk significant survival advantage surface receptor surrogate therapeutic therapeutic strategy Transmission Treatment virus worsening [DOI] 10.1002/advs.202003556 PMC 바로가기 [Article Type] Full Paper
Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and FirestormsCardiovascular Medicine Published on 2021-03-252022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] activated bleeding Blood cardiovascular system cascade cause cellular phenotypes circulating Coagulation coagulation cascade Coagulopathies complex composed connective tissue coronavirus COVID-19 pandemic Critical determinant disease Effect Endothelial cell fibrinolysis fibrinolytic fire Firestorm functions group immune cell responses immune cells immune response immune responses Infection Inflammation Inflammatory responses inhibitor Injury Interaction microthrombi modulate morbidity and mortality Pathogenesis pathway Platelet protease Protein Regulatory regulatory pathway representing resulting SARS-CoV-2 serine protease serpin surface receptor Thrombolysis thrombotic tissue injury Treatment Vascular virus [DOI] 10.3389/fcvm.2021.648947 PMC 바로가기 [Article Type] Cardiovascular Medicine
Angiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyomaCovid-19 Article Published on 2021-03-012022-10-30 Journal: Journal of Endometriosis and Pelvic Pain Disorders [Category] COVID-19, [키워드] ACE2 ACE2 mRNA ACE2 protein acute respiratory syndrome age analyzed Cell cellular receptor coronavirus COVID-19 distribution endothelial cells enzyme evaluated Express expressed Extracellular matrix fibroid Human immunohistochemistry immunoreactivity median mRNA myomectomy myometrium PCR Protein real time reproductive Sample SARS-CoV-2 smooth muscle cell staining surface receptor the SARS-CoV-2 tissue tissues uterine uterine leiomyoma variety Vascular endothelium women [DOI] 10.1177/2284026520954068 PMC 바로가기 [Article Type] Covid-19 Article
Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infectionResearch Published on 2021-01-282022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] acute respiratory illness ADME Analysis antiretroviral drugs binding Cell Compound coronavirus Coronavirus infection death diagnosed diagnostic docking drug drugs effective inhibitor Efficacy GRP78 H-bond highest Host hydrophilicity hydrophobic identify in silico drug design In silico method India Infection inhibit inhibitor Interaction Molecular docking study pandemic performed permeation Physicochemical properties receptor Repurposed drug residue Result Retroviral infection reveal S-protein Safe SARS-COV-2 infection screened Side-effect supplementary material surface receptor Toxicity treated Treatment Virtual screening virus Western Ghats [DOI] 10.1186/s43088-021-00095-x PMC 바로가기 [Article Type] Research
Effect of ambient temperature on respiratory tract cells exposed to SARS-CoV-2 viral mimicking nanospheres-An experimental studySARS-CoV-2 바이러스 모방 나노스피어에 노출된 호흡기 세포에 대한 주변 온도의 영향-실험 연구Article Published on 2021-01-282022-09-12 Journal: Biointerphases [Category] 진단, [키워드] ACE-2 ACE-2 receptor acute respiratory syndrome airway epithelial cell ambient angiotensin-converting enzyme 2 binding bovine Calu-3 caused change coated with Community coronavirus country denaturing Effect fibroblast cell fluctuation had no Host host cell incubated indicated infect Infection Infectious disease Interaction lung epithelia mimicking modulated nonspecific Novel coronavirus occurred pandemic Polymer Protein RBD reached reported respiratory tract respiratory tract cell S protein S-RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral seasonal serum Spread stability surface receptor temperature the S protein the SARS-CoV-2 Transmission Viral transmission virus [DOI] 10.1116/6.0000743 PMC 바로가기 [Article Type] Article
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2Microbiology Published on 2021-01-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor addition Against Antiviral antiviral agent bind cause caused Cell Chloroquine chloroquine/hydroxychloroquine clinical trial conducted Consequences coronavirus coronavirus disease COVID-19 docking drug drugs evaluated Favipiravir global pandemic Hydroxychloroquine inhibitors of SARS-CoV-2 Ivermectin M protein mechanism membrane fusion Membrane proteins molecular dynamics nsp14 Potential Proteases RdRP Remdesivir remdesivir (GS-5734) Replication reported Repurposed drugs Respiratory disease RNA RNA polymerase SARS-CoV-2 screened severity Stage surface receptor target target proteins the binding affinity therapeutic agents TMPRSS2 treatment protocols Trigger viral replication viral spike protein was performed Wuhan [DOI] 10.3389/fmicb.2020.592908 PMC 바로가기 [Article Type] Microbiology