Syncytia

[키워드] 2019 aberrant host response accounted ACE2 Activation activity Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Autopsy block canonical cardiac cardiac complication Cardiac complications cardiac damage cardiac tropism cardiovascular complication cardiovascular complications catalytic site Cell Cell fusion cell lines cell surface cell-cell fusion cells cleavage cleavage site coding coronavirus coronavirus disease correlated COVID-19 COVID-19 patient cytopathic Cytopathic effect cytoplasm cytoplasmic tail direct infection disrupt Drug discovery efficient examined exceeded Express expressed expression vector fluorescent furin furin cleavage motif furin-like protease furin-like proteases fused fusing fusion fusion inhibition green fluorescent protein Human human cardiomyocyte in vitro model inactive Infection inhibition Lungs mechanism monomeric mRNA mutant Mutation Myocardium occur other coronavirus other coronaviruses parental Particle patients peptide-based platform pluripotent stem cell-derived cardiomyocytes protease Protein protein cleavage Proteolytic processing receptor replicate required respiratory respiratory infection SARS-CoV-2 SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus spike Spike protein Spread structures Syncytia systemic inflammation the spike protein These data thrombosis tissue TMPRSS2 Transformed cell transmembrane transmembrane protease serine 2 tropism of SARS-CoV-2 Vesicle Viral viral replication viral transcript viral transcription viral transcripts Virus-like particle virus-like particles viruses
[DOI] 10.1128/JVI.01368-21 PMC 바로가기 [Article Type] Virus-Cell Interactions