Nucleocapsid and spike antibody responses following virologically confirmed SARS-CoV-2 infection: an observational analysis in the Virus Watch community cohortArticle Published on 2022-10-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected age Analysis Anti-N anti-S antibody Antibody Response capillary blood categories Cohort cohort study Community Corona Corona virus COVID-19 COVID-19 infection cumulative eligible England enrolled Evidence female Generation incidence individual Infection nucleocapsid participant past medical history PCR PCR-confirmed peaked polymerase chain positive Primary outcome provided SARS-CoV-2 SARS-COV-2 infection second sensitivity Seroprevalence Serosurveillance Sex Swab System tested vaccination variable [DOI] 10.1016/j.ijid.2022.07.053 PMC 바로가기
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
A Review of Extracorporeal Blood Purification Techniques for the Treatment of Critically Ill Coronavirus Disease 2019 PatientsArticle Published on 2022-10-012022-11-15 Journal: ASAIO journal (American Society for Artificial Int [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome Antiviral apheresis Blood Blood purification caused characterized coronavirus coronavirus disease COVID-19 COVID-19 patients Critically ill Critically ill patient develop drug dysregulated immune response EBP Emergency use Extracorporeal extracorporeal blood purification food highlight host response Ill immune dysregulation Immunomodulatory therapies infected with SARS-CoV-2 Infection Multisystem organ failure novel Betacoronavirus Novel coronavirus outcome pandemic Patient reduce Respiratory illness review SARS-CoV-2 Seraph Spread syndrome System technique the disease the United State with COVID-19 World Health Organization Wuhan, China [DOI] 10.1097/MAT.0000000000001761 PMC 바로가기
A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic CardiomyopathyArticle Published on 2022-09-272022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Analysis Bioinformatic Biology Biomarker Cardiomyopathy cardiovascular system Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 progression datasets DEGs differentially expressed gene disorder drug drug candidates Effect functional Gene Expression Omnibus Genes Genetic GSE147507 identify individual knowledge Lungs microRNA mortality rate; ontology terms other organs patients with COVID-19 protein-protein interaction Proteins Research RNA SARS-CoV-2 Sequencing shared pathway shown statistical Support System therapy transcription factors transcriptomic while [DOI] 10.1155/2022/5337380 PMC 바로가기
Trends in Rotavirus Laboratory Detections and Internet Search Volume Before and After Rotavirus Vaccine Introduction and in the Context of the Coronavirus Disease 2019 Pandemic-United States, 2000-2021Article Published on 2022-09-212022-11-15 Journal: The Journal of Infectious Diseases [Category] 치료기술, [키워드] analyzed average biennial changes in children complement Context coronavirus disease COVID-19 COVID-19 pandemic Decline detection diarrhea enteric Google hospitalizations Infection Internet introduced Laboratory Measures pathogen positive reduction reductions in respiratory rotavirus rotavirus disease rotavirus vaccine suppressed Surveillance System the United State trend Vaccine [DOI] 10.1093/infdis/jiac062 PMC 바로가기
Low SARS-CoV-2 viral load among vaccinated individuals infected with Delta B.1.617.2 and Omicron BA.1.1.529 but not with Omicron BA.1.1 and BA.2 variantsArticle Published on 2022-09-202022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Analysis Asymptomatic disease AZD1222 B.1.1.529 B.1.617.2 BBV152 Case-control Chennai Clinical characteristics clinical history Clustering Complete COVID-19 COVID-19 diagnosis COVID-19 severity Delta demographic characteristics disease Disease progression epidemiological Hospitalized Immune escape India individual Ion Lineage Mutation next generation sequencing number of comorbidities omicron Omicron BA.2 performed Phylogenetic analysis Phylogeny predict Randomly reported RT-PCR SARS-CoV-2 variant SARS-CoV-2 viral load selected selective sequence Severe case severe disease Spread strain System TaqPath unique vaccinated individual vaccine dose variant variants variants of SARS-CoV-2 virological marker virus strains was performed WGS [DOI] 10.3389/fpubh.2022.1018399 PMC 바로가기
Decontamination of Geobacillus Stearothermophilus using the Arca Aerosolized Hydrogen Peroxide decontamination systemArticle Published on 2022-09-202022-11-16 Journal: PLoS ONE [Category] SARS, 임상, 치료기술, [키워드] Bacterial biologic caused clinical setting Concentration conducted Control decontamination effective Efficacy eight evaluate evaluated Greater than growth H2O2 hydrogen Indicator inoculated material Mesa negative control negative controls pandemic peroxide Personal protective equipment positive positive control PPM produced Respirator reuse SARS-CoV-2 sealed Seven System Trial trials [DOI] 10.1371/journal.pone.0273937 PMC 바로가기
Transcriptomics, Cheminformatics, and Systems Pharmacology Strategies Unveil the Potential Bioactives to Combat COVID-19Article Published on 2022-09-132022-11-16 Journal: Molecules [Category] SARS, 유전자 메커니즘, [키워드] addition Analysis analyzed approach caused Cheminformatics co-expression combat Complete COVID-19 determine disease drug candidate Efficiency Features functional Genetic higher efficiency identify immune immune gene Infection Laboratory lack mechanism molecular molecular docking molecular docking analysis Mutation pathway enrichment pharmacological Pharmacology Phytocompounds plant plants Potential Prevalence Regulation required SARS-CoV-2 selected Side effects Signaling Strategy System systems pharmacology. the SARS-CoV-2 virus therapeutic these compound transcriptomics transmission rate treat unique unique genes Vaccinations viral disease [DOI] 10.3390/molecules27185955 PMC 바로가기
Self-testing for SARS-CoV-2 in São Paulo, Brazil: results of a population-based values and attitudes surveyArticle Published on 2022-09-022022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, [키워드] Analysis approach Asymptomatic asymptomatic individual Brazil close contact conducted contribute counseling country COVID-19 COVID-19 disease COVID-19 pandemic dependent variable favor female General population Health help home home diagnostics incidence likelihood majority male onward transmission performed positive Prevent preventive measure questionnaire randomization Randomly Rapid reactive receiving regression analysis SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 testing selected self-isolate self-testing South America survey System Transmission virus was used [DOI] 10.1186/s12879-022-07706-7 PMC 바로가기
Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failureResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acting acute respiratory syndrome Analysis approach biological process biological processe caused cell differentiation China Chinese components Compound compound screening coronavirus COVID-19 COVID-19 case Critical cytokine signaling Cytoscape Cytoscape software Diagnosis drug-likeness Effectiveness enrichment analysis Evidence heart failure Hemostasis identify IL-17 immune system indicated Infection Inflammatory response injection involved KEGG pathway Kyoto Lung injury mechanism Medicine National Health Commission network network analysis novel coronavirus disease objective overlapped Pathway analysis Pathway enrichment analysis Pathways patients with COVID-19 pharmacological mechanism Pharmacological mechanisms Pharmacology progression protein-protein interaction regulated Respiratory failure Result SARS-CoV-2 Shenfu injection signaling pathway Stage suggested syndrome System target targets TCM Th17 therapeutic therapy Traditional treat treating COVID-19 Treatment was used [DOI] 10.1016/j.compbiomed.2022.105845 [Article Type] Research article