SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice개코원숭이에서의 SARS-CoV-2 스파이크 당단백질 백신 후보 NVX-CoV2373 면역원성 및 마우스에서의 보호Article Published on 2021-01-142022-09-12 Journal: Nature Communications [Category] 비임상, 진단, [키워드] angiotensin anti-S antibody anti-S IgG antibody Antigen Antigen-specific T cells B cell binding block CD4 CD8 clinical evaluation COVID-19 pandemic elicit elicited enzyme Evidence evidence of follicular full-length full-length spike protein functional Germinal center hACE2 hACE2 receptor helper T cell high affinity human Angiotensin-converting enzyme immunogenic immunogenicity low-dose Matrix-M mice multifunctional neutralize no evidence of NVX-CoV2373 prefusion conformation PROTECT Protective Protein Protein binding Protein vaccines receptor respiratory Respiratory disease S-protein Safe Saponin SARS-CoV-2 SARS-CoV-2 spike glycoprotein Spike protein spleen Spread subunit Subunit vaccine Support T cells Tfh Vaccine vaccine candidate virus virus infection [DOI] 10.1038/s41467-020-20653-8 PMC 바로가기 [Article Type] Article
Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다Original Article Published on 2020-11-032022-09-12 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단, [키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3 [DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article
The Impact of Malaria Parasites on Dendritic Cell–T Cell Interaction말라리아 기생충이 수지상 세포와 T 세포 상호작용에 미치는 영향Review Published on 2020-07-242024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] DC-T cell interaction dendritic cells malaria T cells T helper cells Tfh [DOI] 10.3389/fimmu.2020.01597 PMC 바로가기 [Article Type] Review
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle AntigenArticle Published on 2018-10-162023-06-24 Journal: Immunity [Category] 신종인플루엔자, [키워드] Antigen presentation antigen-presenting cell APC B cells CD4(+) T cells MYD88 nanoparticle Tfh Th1 TLR Tolerance Toll-like receptor Vaccine Virus-like particle VLP [DOI] 10.1016/j.immuni.2018.08.012