the RBD – Page 3 – Communicable Diseases Research

Design of Three Residues Peptides against SARS-CoV-2 Infection

Article

Published on 2022-09-222022-11-15
Journal: Viruses [Category] SARS, 치료제,

An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

Article

Published on 2022-09-222022-11-15
Journal: PLoS Pathogens [Category] SARS, 진단,

Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein

Article

Published on 2022-09-182022-11-16
Journal: International Journal of Molecular Sciences [Category] SARS, 변종,

Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2

Article

Published on 2022-09-162022-11-15
Journal: Viruses [Category] SARS, 진단,

Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants

Article

Published on 2022-09-142022-11-15
Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 Basis binding binding affinity binding mechanism changes in complexes coronavirus Cross-species transmission cryo-EM cryo-EM structure demonstrated examined expressing F486L facilitate highlight hosts Human human cell human monoclonal antibodies humans identify indicated Infection information Interaction mechanism Microscopy mink molecular mechanism Mutation N501T neutralized prevented Protein pseudovirus RBD RBD variant RBD variants receptor reduced residue SARS-CoV-2 SARS-CoV-2 variant sera Structure the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 transmitted variant variants virus entry viruses Y453F
[DOI] 10.1128/jvi.00814-22 PMC 바로가기

Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody Reactivity

Article

Published on 2022-09-092022-11-15
Journal: ACS Infectious Diseases [Category] SARS, 진단,

Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen

Article

Published on 2022-09-072022-11-15
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제,

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

Article

Published on 2022-09-062022-11-15
Journal: PLoS Pathogens [Category] SARS, 변종, 치료제,

[키워드] ACE2 ACE2 binding affinity angiotensin-converting enzyme 2 Anti-viral antivirals binding biosynthetic build candidate Cell D614G mutation displaying dissemination EC50 EC50 value fusion protein generate hamsters high stability in vitro Infection Interaction mitigate motif nasal nasal epithelium neutralisation activity neutralization neutralized Omicron variants overlapping promote Protein protein sequence proximal RBD Receptor binding domain recognizing reduced Replication SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected targeting the RBD the SARS-CoV-2 trivalent virus virus entry
[DOI] 10.1371/journal.ppat.1010799 PMC 바로가기

Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variants

SARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계

Article

Published on 2022-09-012022-09-11
Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened
[DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article

Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitution

Article

Published on 2022-09-012022-11-16
Journal: Acta crystallographica. Section D [Category] SARS, 변종,

[키워드] ACE2 ACE2 receptor addition amino-acid Analysis base binding binding affinity binding kinetics circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants complex Contact contribute COVID-19 host-pathogen interactions in vitro in vivo model increase increase in Infection Interaction Lineage mice modulate mutant Mutation performed Q498Y RBD RBD-ACE2 RBD–ACE2 complex receptor ACE2 Receptor binding domain reveal SARS-CoV-2 SARS-CoV-2 variant shown Spike protein spike protein Q498Y mutation spike protein receptor binding domain. spike receptor-binding domain Substitution the binding affinity the RBD the SARS-CoV-2 the spike protein while wild-type counterpart X-ray X-ray structure
[DOI] 10.1107/S2059798322007677 PMC 바로가기