High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia혈장 내 갈렉틴-9 및 오스테오폰틴의 높은 수준은 COVID-19 폐렴의 중증도를 반영하는 염증 마커와 관련이 있습니다Article Published on 2021-05-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 진단, [키워드] Analysis association Bacterial infection C-reactive protein can be used cleaved Coagulopathy coronavirus disease Coronavirus disease 2019 Correlation analysis COVID pneumonia COVID-19 COVID-19 patient CP group CP patient CP patients elevated ferritin followed by form full-length full-length galectin-9 full-length osteopontin Galectin-9 healthy individuals highest Infectious diseases Inflammation inflammatory biomarkers inflammatory markers interleukin Kidney function Laboratory Level Lung function marker mild clinical symptom mild clinical symptoms MONITOR number osteopontin Patient Plasma level Plasma levels plasma sample plasma samples Pneumonia Proteases Protein reduced ROC analysis severity significantly Spearman’s correlation suggested therapeutic effect therapeutic effects therapy Tocilizumab treated truncated galectin-9 undefined osteopontin [DOI] 10.3390/ijms22094978 PMC 바로가기 [Article Type] Article
Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients패혈증 또는 패혈성 쇼크 및 COVID-19 환자를 치료하기 위해 용도가 변경된 단트롤렌Review Published on 2021-04-012022-09-11 Journal: European review for medical and pharmacological sc [Category] MERS, SARS, 신약개발, 진단, [키워드] Cell Clinical studies COVID-19 patient Critical Dantrolene decrease Disruption Endoplasmic reticulum expected homeostasis inhibitor intracellular Ca2+ MODS molecular Mortality multiple organ dysfunction multiple organ dysfunction syndrome organ organ dysfunction syndrome pathology patients potential mechanism potential mechanisms provided receptor Ryanodine Sepsis Septic shock SIRS syndrome systemic inflammatory response systemic inflammatory response syndrome therapeutic effect therapeutic effects treat [DOI] 10.26355/eurrev_202104_25569 PMC 바로가기 [Article Type] Review
Compounds of plants with activity against SARS-CoV-2 targetsArticle Published on 2021-03-302023-07-02 Journal: Expert review of clinical pharmacology [Category] SARS, [키워드] compounds medicinal plants SARS-CoV-2 targets therapeutic effects [DOI] 10.1080/17512433.2021.1903317 PMC 바로가기
Tackling COVID-19 Using Remdesivir and Favipiravir as Therapeutic Options치료 옵션으로 렘데시비르 및 파비피라비르를 사용하여 COVID-19 대처Review Published on 2021-03-162022-09-11 Journal: Chembiochem [Category] SARS, 치료제, [키워드] COVID-19 drug Favipiravir life cycle measure option outbreak pandemic provide RDV Remdesivir researcher routes of transmission. therapeutic effect therapeutic effects Transmission transmission of SARS-CoV-2 Treatment strategies treatment strategy [DOI] 10.1002/cbic.202000595 PMC 바로가기 [Article Type] Review
Radiology indispensable for tracking COVID-19Mini review Published on 2021-02-012022-10-05 Journal: Diagnostic and interventional imaging [Category] 치료기술, [키워드] addition artificial intelligence Chest Chest computed tomography chest X-ray children Computed tomography COVID-19 Critical diagnosing Diagnosis early stage effective false-negative rate gold standard group helping highlight Isolation magnetic resonance imaging Manifestations nuclear nucleic acid pandemic Pneumonia Positron emission tomography computed tomography. pregnant women Prevent problem radiological radiology SARS-CoV-2 severity spread of COVID-19 suspected patient suspected patients the disease therapeutic effects time-consuming tomography Transmission X-ray computed [DOI] 10.1016/j.diii.2020.11.008 [Article Type] Mini review
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 수용체 결합 도메인을 표적으로 하는 치료 중화 항체Article Published on 2021-01-122022-09-10 Journal: Nature Communications [Category] 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate alleviation angiotensin angiotensin converting enzyme animal model antibodies antibody Antibody therapy Antibody-dependent enhancement block caused Clinical symptoms Complex crystal structure convalescent convalescent patient coronavirus COVID-19 COVID-19 patient crystal structure D614G variant enzyme evaluated hamster human monoclonal antibodies Human monoclonal antibody Infection Interaction mAb mAbs mononuclear cell mononuclear cells neutralize neutralizing antibody Orientation pandemic Peripheral blood Peripheral blood mononuclear cells RBD receptor Receptor binding domain reduce reduction in Region reported respiratory rhesus SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein Symptom the SARS-CoV-2 therapeutic therapeutic effect therapeutic effects Therapeutics Vaccine Viral viral infection viral spike protein viral titer [DOI] 10.1038/s41467-020-20602-5 PMC 바로가기 [Article Type] Article
COVID-19, myocardial edema and dexamethasoneCOVID-19, 심근 부종 및 덱사메타손Article Published on 2020-12-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Antiviral antiviral agent ARDS cause of death Corona virus coronavirus coronavirus disease COVID-19 cytokine Cytokine storm syndrome death develop Dexamethasone Dyspnea edema effective endothelial FDA gcs glucocorticoid Glucocorticoids high mortality rate Hospitalized hospitalized COVID-19 patients Hypoxemia kidney lead Liver injury Myocardial Myocardium Numerous Patient patient with COVID-19 poor prognosis progression randomized trial reducing mortality respiratory respiratory distress Respiratory failure Safe Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus severe COVID-19 stability syndrome therapeutic effect therapeutic effects tissue Treatment Vascular vascular permeability virus [DOI] 10.1016/j.mehy.2020.110307 PMC 바로가기 [Article Type] Article
Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19Lianhua Qingwen 캡슐에 대한 네트워크 약리학 및 분자 도킹 분석은 Akt1이 COVID-19를 치료하고 예방하는 잠재적인 표적임을 나타냅니다Original Article Published on 2020-11-032022-08-31 Journal: Cell Proliferation [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] AKT1 Analysis Apoptosis Chinese Chinese patent medicine Compound conducted coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 Critical database docking drug target effective enrichment analysis Gene ontology gene target Genes help hub genes identify immune defense immune response indicated Inflammatory response Interaction involved kaempferol KEGG Kyoto Lianhua Qingwen capsule lung Lung injury Luteolin material Medicine molecular docking molecular mechanism naringenin network network pharmacology nine objective Ontology Patient performed pharmacological Pharmacology potential mechanism PPI PPI network Prevent Protein quercetin reduce Result selected Seven shown System targets therapeutic effect therapeutic effects tissue damage Traditional Traditional Chinese medicine treat virus infection was performed wogonin [DOI] 10.1111/cpr.12949 PMC 바로가기 [Article Type] Original Article
Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a reviewReview Published on 2020-09-252022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] absorbed activity Allergic reactions Analysis anticancer antiinflammatory Antiviral article baicalein Brain caused China Chinese Clinical symptoms clinical trials component components cough COVID-19 described disease Effects follow-up study ingredient kidney liver Liver fibrosis manifested network pharmacology pharmacokinetics pharmacological Pharmacological Effects Pharmacopoeia phytochemistry processed Research SB applications Scutellaria baicalensis shown TCM therapeutic effect therapeutic effects Toxicity treat treating COVID-19 [DOI] 10.1186/s13020-020-00384-0 PMC 바로가기 [Article Type] Review
Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?Editorial Published on 2020-09-172022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] acute respiratory syndrome Anti-inflammatory coronavirus Coronavirus-2 COVID-19 COVID-19 patient COVID-19 positive patients drugs Effect Epidemic health emergency human Oral Tissue Stem Cells immunomodulation immunomodulatory immunomodulatory therapy Infection Mesenchymal stem cells MSCs Non-invasive offer oral pathway Patient Prophylaxis recent risk SARS-CoV-2 Secretome shown STEM stem cell syndrome therapeutic therapeutic effects Treatment Vaccine [DOI] 10.3390/ijms21186833 PMC 바로가기 [Article Type] Editorial