COVID-19 as an Immune Complex Hypersensitivity in Antigen Excess Conditions: Theoretical Pathogenetic Process and Suggestions for Potential Therapeutic Interventions항원 과잉 조건에서 면역 복합 과민증으로서의 COVID-19: 이론적 병인 과정 및 잠재적 치료 개입에 대한 제안Immunology Published on 2020-10-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE-2 receptor activated Activation anti-spike antibodies Antigen antigen excess antigenic nature Asymptomatic carried Coagulation complement Complement activation complement system complex component conditions COVID-19 Critical determine develop excess Factor FIBRIN homeostasis Human immune system hypersensitivity Hypothesis hypothetical IgM and IgG immune complex immune response immune response mechanisms induce Infection inflammatory factors innate immune interfere Kawasaki-like disease lung macrophages membrane neutrophil Neutrophils occur pathology Potential Process Severe patient Spike antigen subject suggestion supported symptomatic systemic disorders therapeutic intervention thrombi tissue tissue damage vascular inflammation Viral viral infection Viral proteins virus [DOI] 10.3389/fimmu.2020.566000 PMC 바로가기 [Article Type] Immunology
Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studiesOriginal Article Published on 2020-07-022023-06-17 Journal: Histopathology [Category] MERS, SARS, [키워드] COVID‐19 Diffuse alveolar damage immunohistochemistry Lung histopathology next generation sequencing SARS‐CoV‐2 thrombi Viral pneumonia [DOI] 10.1111/his.14201 PMC 바로가기 [Article Type] Original Article