Limb ischemia due to spontaneous heparin-induced thrombocytopenia as the primary presentation of acute COVID-19 infection급성 COVID-19 감염의 주요 증상인 자발적 헤파린 유발 혈소판 감소증으로 인한 사지 허혈Case Reports Published on 2022-08-012022-09-12 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 진단, [키워드] 2019 coronavirus disease absence activate acute COVID-19 addition administration antibodies characterized complexes COVID-19 develop enzyme-linked immunosorbent had no heparin Hospitalization IgG antibody immunoglobulins, intravenous Infection instances Intravenous immunoglobulin Ischemia less male occur Pain Patient PF4 Platelet platelet activation positive presenting prothrombotic condition reported Serotonin Spontaneous spontaneous heparin-induced thrombocytopenia SRA syndrome thrombocytopenia thrombosis treated Vaccinations [DOI] 10.1007/s11239-022-02676-8 PMC 바로가기 [Article Type] Case Reports
Long-Term Outcomes after Vaccine-Induced Thrombotic Thrombocytopenia백신 유도성 혈전성 혈소판 감소증 후 장기 결과Article Published on 2022-08-012022-09-11 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] acute phase Adenovirus adenovirus-based affected antibody Anticoagulants anticoagulation appear Arterial thrombosis AZD1222 bleeding cerebral venous sinus thrombosis ChAdOx1 ChAdOx1 nCoV-19 Cohort Cohort studies cohort study Complication coronavirus Corticosteroids COVID-19 D-dimer detectable diagnosed Diagnosis died dimer Direct discharge discharged eculizumab effective elevated enrolled Follow-up hospital hospital discharge Immunoglobulin in some Intravenous immunoglobulin IVIG limit management nCoV neurological nine observation occurred one patient oral anticoagulant outcome Patient patients PF4 Platelet platelet activation positive prothrombotic condition remained respiratory respiratory syndrome coronavirus respiratory syndrome coronavirus 2 Safe SARS-CoV-2 serious complication Seven severe respiratory syndrome single-center Sinus thrombosis survived Symptom symptom onset syndrome the disease thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events thrombosis thrombotic Thrombotic thrombocytopenia Treatment two patients vaccination Vaccine venous venous sinus were given [DOI] 10.3390/v14081702 PMC 바로가기 [Article Type] Article
Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다Article Published on 2022-07-122022-09-11 Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy [DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article
Thrombosis and thrombocytopenia in COVID-19 and after COVID-19 vaccinationCOVID-19 및 COVID-19 백신 접종 후의 혈전증 및 혈소판 감소증Review Published on 2022-07-012022-09-11 Journal: Trends in cardiovascular medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system Adenovirus Adenovirus-vectored vaccine administration aggregation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antibody detection Antiplatelet factor cause Coagulation Coagulopathy condition coronavirus coronavirus disease COVID-19 COVID-19 vaccination Critical detect diagnosing Diagnosis Disease progression disease severity dysregulation effective ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay event false-positive rate false-positive rates hemophagocytic lymphohistiocytosis hemophagocytic syndrome immune Immune thrombocytopenic purpura Inflammation initial Interaction lupus erythematosus Messenger RNA mitigate occur optical optical density Pathogenesis PF4 Platelet platelet aggregation Platelets positive progression purpura SARS-CoV-2 serious complication severe acute respiratory syndrome Coronavirus Side effects Spike protein syndrome systemic lupus erythematosus the disease the patient thrombocytopenia thrombocytopenic purpura Thromboembolism thrombosis thrombotic Thrombotic thrombocytopenia Thrombotic thrombocytopenic purpura vaccination Vaccine Vaccines vectored vaccine [DOI] 10.1016/j.tcm.2022.02.008 PMC 바로가기 [Article Type] Review
Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers ColloquiumCOVID-19의 혈전 위험에 대한 현재 및 신규 바이오마커: 국제 COVID-19 혈전증 바이오마커 콜로키움의 합의 성명Review Published on 2022-07-012022-09-11 Journal: Nature reviews. Cardiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 치료기술, 치료법, [키워드] Activation aggregation Biomarker Biomarkers Clinical use Coagulation Coagulopathy Consensus coronavirus disease Coronavirus disease 2019 COVID-19 current D-dimer disease disease severity Elevation elevations Endothelial cell excessive inflammation fibrinogen fibrinolysis hypercoagulability in-hospital mortality Injury Intervention marker pandemic Patient patients Platelet platelet activation platelet aggregation platform Post-vaccine predict Prognosis prothrombotic recommendation Research risk risk stratification syndrome thrombocytopenia thromboembolic Thromboembolic events thrombosis thrombotic thrombotic and thromboembolic events thrombotic risk with COVID-19 [DOI] 10.1038/s41569-021-00665-7 PMC 바로가기 [Article Type] Review
COVID-19 mRNA vaccine-associated encephalopathy, myocarditis, and thrombocytopenia with excellent response to methylprednisolone: A case reportShort communication Published on 2022-07-012022-10-05 Journal: Journal of neuroimmunology [Category] 바이오마커, 진단, [키워드] adverse event Autoimmune BNT162b2 Case report cause clinical Clinical features clinician Complication Convulsion COVID-19 COVID-19 vaccination described Diagnostic Criteria effective strategy Encephalitis Encephalopathy female Fever immune Laboratory Methylprednisolone mRNA myocarditis notable pandemic of COVID-19 Pathogenesis Patient Pfizer-BioNTech mRNA vaccine Pfizer-BioNTech mRNA vaccine (BNT162b2) Research responsible SARS-CoV-2 second dose significantly the vaccine thought thrombocytopenia vaccination Vaccine-associated encephalopathy [DOI] 10.1016/j.jneuroim.2022.577883 [Article Type] Short communication
Association between thrombocytopenia and the severity of Covid-19 infection among hospitalized Egyptian patientsResearch article Published on 2022-07-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 바이오마커, [키워드] acute respiratory syndrome addition ARDS association cause caused Clinical sign COVID-19 Critically ill Critically ill patient critically ill patients cross-sectional death Disseminated intravascular coagulopathy distress evaluate group hemorrhage Hospitalized hospitalized patients hypoxia Infection Laboratory lung dysfunction occurred outcome parameter Patient patients with COVID-19 Pneumonia radiological evidence Respiratory failure risk Severe acute respiratory syndrome Severe patient severity severity of COVID-19 statistically statistically significant difference symptomatic patient syndrome systemic illness thrombocytopenia virus was done [DOI] 10.1016/j.amsu.2022.103973 [Article Type] Research article
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human ProteinsSARS-CoV-2 스파이크와 인간 단백질 간의 분자 모방으로 인한 잠재적 자가면역Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adverse reactions AlphaFold2 antibody Antibody binding Asymptomatic Autoimmune Autoimmunity calcium cardiac disease cause coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patients cross-reacting antibodies disease disorder Epitopes example explanation highlight host protein host proteins hotspot Human human proteins implication induce investigated involved machine learning mimicry molecular molecular dynamics molecular mimicry motif omicron outcomes platelet activation Potential PRKG1 Protein protein structure protein structure comparison reduce Regulation resulting SARS-CoV-2 SARS-CoV-2 spike spike Symptom therapeutic intervention therapeutic interventions thrombocytopenia Thrombopoietin tropomyosin Vaccine Vaccine design variant Viral Viral antigen viral antigens [DOI] 10.3390/v14071415 PMC 바로가기 [Article Type] Article
Evaluation of hematological parameters and thrombocytopenia following Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccinationArticle Published on 2022-06-012023-07-09 Journal: Saudi medical journal [Category] COVID19(2023년), [키워드] COVID-19 COVID-19 pandemic Pfizer-BioNTech Platelets SARS-CoV-2 thrombocytopenia Vaccine [DOI] 10.15537/smj.2022.43.6.20220135 PMC 바로가기
Phenotype Algorithms for the Identification and Characterization of Vaccine-Induced Thrombotic Thrombocytopenia in Real World Data: A Multinational Network Cohort StudyObservational Study Published on 2022-06-012022-10-05 Journal: Drug safety [Category] 임상, [키워드] age applied approach baseline characteristics characterization characterized co-occurrence Cohort Comorbidities conducted coronavirus disease COVID-19 defined Diagnosis Electronic health record embolic event Health heterogeneity heterogeneous identification incidence rate International men network Observational data Older age Patient patients phenotype Phenotypes ranged reported retrospective cohort study Serious Adverse Event Sex thrombocytopenia thrombosis thrombotic thrombotic event Vaccines venous [DOI] 10.1007/s40264-022-01187-y PMC 바로가기 [Article Type] Observational Study