COVID-19-associated atypical hemolytic uremic syndrome and use of Eculizumab therapyCOVID-19 관련 비정형 용혈성 요독 증후군 및 Eculizumab 요법의 사용Case Reports Published on 2022-01-012022-09-12 Journal: Journal of Nephrology [Category] MERS, SARS, 진단, [키워드] Activation Acute kidney injury acute tubular necrosis Atypical complement complex COVID-19 eculizumab etiology Hispanic incidence infections kidney male therapy thrombotic thrombotic microangiopathy treated uremic syndrome with COVID-19 [DOI] 10.1007/s40620-021-01125-8 PMC 바로가기 [Article Type] Case Reports
Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reportsCase Report Published on 2021-12-132022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] accelerated Activation ADAMTS13 Adults Atypical Atypical hemolytic uremic syndrome Case report case sery caused Complement pathway Complete complications coronavirus disease COVID-19 female had no hematologic Hemodialysis hemolytic anemia Hispanic Infection influenza A knowledge Laboratory male Nonimmune hemolytic anemia Patient precipitated presenting renal reported SARS-CoV-2 thrombotic thrombotic microangiopathy treated uremic uremic syndrome [DOI] 10.1186/s13256-021-03144-2 PMC 바로가기 [Article Type] Case Report
Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunctionMIS-C 환자의 단백질체 프로파일링은 인터페론 감마 조절 장애 및 혈관 내피 기능 장애와 관련된 이질성을 나타냅니다.Article Published on 2021-12-102022-09-10 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Asymptomatic chemokines children clinical heterogeneity comprehensive analysis coronavirus coronavirus 2 disease dysregulated dysregulation Endothelial dysfunction heterogeneity hyperinflammation Hyperinflammatory identify IFN-γ IFN-γ response IFNγ IFNγ level IFNγ levels indicate Infection infection with SARS-CoV-2 Inflammation Inflammatory initial interferon gamma interferons Macrophage macrophage activation syndrome marker mediators Mild MIS-C overlap pathogenic Patient patients Pediatric patients phenotype PLA2G2A plasma Predictive markers Protein proteome respiratory response rheumatology SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Symptoms syndrome thrombotic thrombotic microangiopathy Vascular Vascular injury viral infection Week [DOI] 10.1038/s41467-021-27544-6 PMC 바로가기 [Article Type] Article
Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson’s syndromeAsherson의 증후군을 회상하는 치명적인 COVID-19에서 비정상적인 면역 혈전증 및 루푸스 항응고제Case Reports Published on 2021-11-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 유전자 메커니즘, 진단, [키워드] Abnormal immunothrombosis Anticoagulant Antiphospholipid syndrome (Hughes syndrome) approach Asherson’s syndrome Care catastrophic Coagulation complex condition coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 death develop disease Disseminated intravascular coagulation Genetic predisposition high mortality rate Hospitalization hypercytokinemia immunothrombosis intravascular coagulation Lupus lupus anticoagulant Lupus anticoagulant (LAC) male mechanism Megakaryocytes. multidisciplinary approach multiple organ failure occurred overlapping Patient required syndrome the disease thrombotic thrombotic microangiopathy Viral viral infections [DOI] 10.1007/s11239-021-02444-0 PMC 바로가기 [Article Type] Case Reports
Complement levels at admission as a reflection of coronavirus disease 2019 (COVID-19) severity state코로나바이러스 질병 2019(COVID-19) 심각도 상태를 반영하여 입원 시 보완 수준Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 ADAMTS13 Admission adverse outcome adverse outcomes analyzed association benefit Blood blood sample Blood samples C3a C3a/C3 Clinical improvement complement complement system confounders coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation correlations Course COVID-19 COVID-19 illness COVID-19 patient COVID-19 severity disease severity displaying elevated emergency department enrolled Evidence evidence of fibrinogen highest Hyperactivation hyperinflammation Hyperinflammatory implicated infected patients inflammatory biomarkers investigated moderate organ damage over parameter Patient phenotype plasminogen predict presenting Primary outcome progression Research respiratory SARS-CoV-2 SARS-CoV-2 hyperinflammation secondary outcome severe acute respiratory syndrome Coronavirus severe COVID-19 illness severe disease severity significantly therapy thrombotic thrombotic microangiopathy tissue [DOI] 10.1002/jmv.27077 PMC 바로가기 [Article Type] Article
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients폰 빌레브란트 인자와 ADAMTS13 축의 불균형은 코로나19 중환자에서 혈전 과정의 원인이라기보다는 오히려 강한 염증과 내피 손상의 바이오마커Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커, [키워드] ADAMTS13 ADAMTS13 conformation Admission alveolar capillaries alveolar capillary Antigen Biological Biomarker Biomarkers Clinical features contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer deaths deficiency disintegrin driver Drivers elevated endothelial damage enrolled factor V fibrinogen hallmark hemolytic anemia hospital Imbalance Immune-mediated induce Inflammation Laboratory parameters male-to-female ratio median age microangiopathic hemolytic anemia microthrombi Microthrombosis Mortality open Patient patients Platelet Pulmonary embolism pulmonary embolisms purpura Quantitative reported Seven severe deficiency specificity thrombocytopenia thrombocytopenic purpura thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura type I von Willebrand factor vWF [DOI] 10.1111/jth.15445 PMC 바로가기 [Article Type] Article
Atypical Hemolytic Uremic Syndrome (aHUS) and Adenosine Deaminase (ADA)-Deficient Severe Combined Immunodeficiency (SCID)—Two Diseases That Exacerbate Each Other: Case ReportCase Report Published on 2021-08-312024-09-02 Journal: International Journal of Molecular Sciences [Category] 대상포진, [키워드] adenosine deaminase deficiency Atypical hemolytic uremic syndrome children severe combined immunodeficiency thrombotic microangiopathy [DOI] 10.3390/ijms22179479 PMC 바로가기 [Article Type] Case Report
Renal Thrombotic Microangiopathy in Concurrent COVID-19 Vaccination and InfectionCase Report Published on 2021-08-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute renal injury administration association Complete concurrent correlation COVID-19 COVID-19 diagnosis COVID-19 vaccination COVID-19 vaccine described Endothelial cell endothelial injury event Evidence feature first dose healthy High-dose histological hospital injection Injury Kidney disease Laboratory test microangiopathy of BNT162b2 Patient Pfizer-BioNTech positive question renal reported RT-PCR SARS-CoV-2 SARS-COV-2 infection serum creatinine steroid treatment tested the vaccine thrombotic thrombotic microangiopathy Urine Vaccine vaccine injection with COVID-19 [DOI] 10.3390/pathogens10081045 PMC 바로가기 [Article Type] Case Report
Tackling COVID-19 infection through complement-targeted immunotherapy보체 표적 면역 요법을 통한 COVID-19 감염 퇴치Review Published on 2021-07-012022-09-11 Journal: British Journal of Pharmacology [Category] SARS, 변종, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus 2 anaphylatoxin anaphylatoxins article Blood C3a C5a complement Complement activation complement system coronavirus coronavirus 2 COVID-19 infection COVID-19 patient Crosstalk death disease Disease progression effector molecules Endothelial cell endothelial cells function Health high mortality higher risk highly pathogenic immune system Immunotherapy Injury Innate immunity knowledge lectin lectin pathway Pathogenesis prevalent Regulation regulator gene reported resulting Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease subsequent thrombotic thrombotic microangiopathy variant [DOI] 10.1111/bph.15187 PMC 바로가기 [Article Type] Review
Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy증례 보고서: 성인 포스트-COVID-19 다기관 염증 증후군 및 혈전성 미세혈관병증Case Reports Published on 2021-06-232022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] affected blocker Case report children complement complement system coronavirus disease COVID-19 described eculizumab Inflammatory initiated microangiopathy MIS MIS-C Multisystem inflammatory syndrome pandemic pathophysiology presentation renal renal function SARS-COV-2 infection Specific syndrome therapeutic option thrombotic thrombotic microangiopathy [DOI] 10.3389/fimmu.2021.680567 PMC 바로가기 [Article Type] Case Reports