C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19
C5a 및 C5aR1은 aHUS에서 COVID-19에 이르는 임상 기관에서 미세혈관 혈소판 응집의 주요 동인입니다
Article
[키워드] Activation
acute respiratory syndrome
added
aggregation
Alternative pathway
antithrombogenic
Atypical
Bacterial infection
Bacterial infections
binding
blockade
C5a
C5aR1
C5b-9
caused
CCX168
Cell
chronic inflammatory diseases
clinical entity
clinical implications
Comorbidities
Comorbidity
complement
complement system
coronavirus
COVID-19
Critical
demonstrated
develop
driver
dysfunction
dysregulation
Effect
endothelial
endothelial cells
Endothelial dysfunction
Endothelium
Ex vivo
Exocytosis
Genetic
hemolytic uremic syndrome
highlight
human serum
Hyperactivation
Infection
Inflammatory diseases
Microvascular thrombosis
normal human serum
P-selectin
pathogenic mechanisms
Patient
patients treated
Platelet
platelet adhesion
prothrombotic
RalA
rare disease
Registered
selectin
serum
severe acute respiratory syndrome Coronavirus
severe COVID-19
severely ill patients
suffered
thrombosis
Thrombus
thrombus formation
translate
Trial
triggered
uremic syndrome
viral infections
von Willebrand factor
[DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article
[DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article