Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious DiseasesReview Published on 2022-02-162022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] accelerated Activation adaptive immune responses adjuvant adjuvants advance agonist Antigen boost COVID-19 pandemic development Diseases Effect effective efficient epidemic diseases Human Vaccines immune response immune responses inactive Infection Infectious disease innate immune responses microbial microbial infection molecular mechanism MPL mRNA vaccine nasal adjuvant pathogen pattern recognition receptor powerful tool PRR recent recognize Research Safe subsequent subunit target TLR TLR agonist TLRs Toll-like receptor Trigger Vaccine [DOI] 10.3390/pharmaceutics14020423 PMC 바로가기 [Article Type] Review
High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike AntigensObservation Published on 2022-02-162022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, [키워드] adjuvant aluminum animal models Antigen Beta candidate vaccine Combination COVID-19 COVID-19 vaccine defined Delta delta variant distribution driven by Efficacy elevated humoral hydroxide immune response Immunity immunity after vaccination immunogenic in vitro induced mice NAb NAb titer NAbs neutralize Neutralizing Pathways plasma produced PROTECT Protective protective immunity Protein receptor response Safe SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike protein subunit Subunit vaccine Support sustained the SARS-CoV-2 TLR TLR8 trimeric trimeric spike vaccination Vaccine vaccine candidate variant [DOI] 10.1128/spectrum.01695-21 PMC 바로가기 [Article Type] Observation
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like propertiesSARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거Article Published on 2022-02-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection [DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 VaccinationImmunology Published on 2022-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured [DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AIDArticle Published on 2022-01-042022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, [키워드] acute respiratory syndrome adjuvants Affect antibody B cell B cell response BCR coronavirus Cytidine deaminase deficiency demonstrated deubiquitinase domain expression Extracellular function Genes HIV-1 Human immunodeficiency virus immunization immunology initiate mechanisms Molecular biology neutralizing antibody NLS nuclear nucleus Phosphorylation promoted Protein protein levels Recombination reducing regulate SARS-CoV-2 significantly TLR USP10 Vaccine Vaccines [DOI] 10.1038/s41392-021-00858-z PMC 바로가기 [Article Type] Article
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsToll-유사 수용체 7의 희귀 변이는 COVID-19 환자에서 기능 손상 및 사이토카인 매개 신호의 하향 조절을 초래합니다Brief Communication Published on 2021-12-242022-09-10 Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACOD1 affected antiviral responses Cell Chronic diseases component COVID-19 patient CXCL10 Cytokines decrease downregulation failure functional Genes genetics hypomorphic IFIT2 IFN IFNα IFNγ imiquimod immune responses immunology impairment innate antiviral responses innate immune response innate immune responses interferons loss-of-function male men mononuclear cell mononuclear cells mRNA level mRNA levels Pathogens pathway Patient performed Peripheral blood Peripheral blood mononuclear cells pro-inflammatory cytokine pro-inflammatory cytokines recognize responses responsible RNA sequencing RSAD2 SARS-CoV-2 severe COVID-19 Signaling single-stranded RNA virus Stimulation TLR TLR7 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors Transcriptome triggering type I upregulation variant variants Variation variety viruses was performed [DOI] 10.1038/s41435-021-00157-1 PMC 바로가기 [Article Type] Brief Communication
The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λResearch Article Published on 2021-12-222022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting [DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteinsSARS-COV-2 스파이크 에피토프 서열의 분자 도킹으로 인간 Zo-1, TLR8 및 뇌 특이적 신경교 단백질과의 이종이량체 펩티드-단백질 복합체 형성 확인Article Published on 2021-12-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] allele asphyxia binding Blood brain barrier blurred vision Brain Brain infection cause clinical observation clinical observations complex death deviation docking epitope epitope peptide Epitopes experiment Glia glial cell headache heterodimeric HLA-DRB1 Human brain human population Hypothesis identify immunogenic induce infect Infection Inflammation Interaction Loss of Smell mechanism modify molecular molecule NDRG2 neurological abnormalities neurological abnormality observation observations peptide peptides performed Protein Proteins question receptor respiratory tract illness RMSD root S100B SARS-CoV-2 SARS-COV-2 infection selected sequence specific protein spike spike epitopes Spike protein structures Symptoms tested the Spike TLR TLR8 Toll-like receptor VCAM1 virus working hypothesis zonula zonula occludens [DOI] 10.1016/j.mehy.2021.110706 PMC 바로가기 [Article Type] Article
EpiCurator: an immunoinformatic workflow to predict and prioritize SARS-CoV-2 epitopesBioinformatics Published on 2021-11-302022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] analyzed antigenic antigenicity approaches assist candidate clinical trial Combination Coronavirus 2019 Coverage COVID-19 demonstrated described effective effective vaccine Effectiveness Efficacy Efficiency EpiCurator epitope Epitopes prediction GISAID database global public health glycoprotein HLA alleles binding affinity IEDB Immune Epitope Database immune response immunogenic potential Immunoinformatic approaches in silico in vitro Interaction pandemic predict Prevent RBD Research retrieved SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 genome SARS-CoV-2 virus sequence spike stability the receptor-binding domain the vaccine TLR triggered variants of concern virus genome virus spread [DOI] 10.7717/peerj.12548 PMC 바로가기 [Article Type] Bioinformatics