In silico designing of a novel polyvalent multi-subunit peptide vaccine leveraging cross-immunity against human visceral and cutaneous leishmaniasis: an immunoinformatics-based approachOriginal Paper Published on 2023-03-162024-09-05 Journal: Journal of molecular modeling [Category] update2024, [키워드] homology modeling Leishmaniasis molecular dynamic simulation Multi-epitope vaccine reverse vaccinology TLR [DOI] 10.1007/s00894-023-05503-w PMC 바로가기 [Article Type] Original Paper
Exploring the Role of GMMA Components in the Immunogenicity of a 4-Valent Vaccine against Shigella시겔라에 대한 4가 백신의 면역원성에서 GMMA 성분의 역할 탐색Article Published on 2023-02-012024-08-22 Journal: International Journal of Molecular Sciences [Category] 세균성이질, [키워드] Generalized Modules for Membrane Antigens (GMMA) OMV Proteins Shigella TLR Vaccine
Toll-like receptor 10 has a role in human macrophage response against Streptococcus pneumoniaearticle Published on 2022-10-312024-09-01 Journal: Cell and Tissue Research [Category] 폐렴구균 감염증, [키워드] Asthma human lung Lung inflammation Pneumonia TLR [Article Type] article
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activityResearch article Published on 2022-08-242022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] acute respiratory syndrome antiviral activity antiviral response antiviral therapeutic antiviral therapeutics base base pairs blunt cell lines Characteristics coronavirus coronavirus disease COVID-19 described DNA double-stranded RNA dsRNAs groups highlight Hoogsteen G-G base pairing human lung IFN IFN-I IFN-III immunostimulant immunostimulatory immunostimulatory RNA independent induce Infection Influenza influenza A virus interferon lack lung MERS-CoV Middle East monophosphate motif MT: Oligonucleotides not affect organ on a chip pandemic pathophysiology pathway proinflammatory receptor respiratory syndrome coronavirus respiratory virus RIG-I RNA RNAs SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence siRNAs terminal hydroxyl Therapies and Applications TLR type I type III interferon unique [DOI] 10.1016/j.omtn.2022.08.031 [Article Type] Research article
Jetstream Atherectomy Followed by Paclitaxel-Coated Balloons versus Balloon Angioplasty Followed by Paclitaxel-Coated Balloons: Twelve-Month Exploratory Results of the Prospective Randomized JET-RANGER StudyRandomized Controlled Trial Published on 2022-08-022022-10-05 Journal: Vascular Health and Risk Management [Category] 임상, [키워드] Analysis angioplasty assigned association atherectomy bailout stenting balloon Boston claudication COVID-19 death disease dissections distal drug-coated balloons Enrollment evaluated exploratory femoropopliteal Follow-up followed by intention to treat JET Jetstream lesions Medtronic Mortality multicenter outcome Patient patients primary end point Prospective provide Randomized randomized trial Randomly Ranger, In.PACT reduction in Result TLR Treatment two groups variable vessel vessel prepping. was performed were used [DOI] 10.2147/VHRM.S371177 PMC 바로가기 [Article Type] Randomized Controlled Trial
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literatureReview article Published on 2022-08-012022-10-05 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE addition affecting age article association CCR5 cellular protease Clinical outcome Comorbidities correlation COVID-19 COVID-19 severity Deletion evaluate expression finding Genetic Genetic predisposition genetic risk genetic susceptibility genetics help HLA haplotypes host genetics IFNs IFNλ immune system individual Mortality mutations polymorphism Polymorphisms Proteins reduced retrieved risk risk factor SARS-CoV-2 several gene severity severity of COVID-19 smoking susceptibility systematic review TLR TMPRSS2 TNF Treatment upregulation vaccination Variability with COVID-19 [DOI] 10.1016/j.gene.2022.146674 [Article Type] Review article
Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant오미크론 COVID-19 변이체에 대한 다중 에피토프 백신 구축을 위한 면역정보학적 접근Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] added adjuvant antigenic antigenic epitope antigenic epitopes applied approach B cell epitope B cell epitopes B-cell B.1.1.529 CD4 CD8 chimeric Chimeric vaccine model codon optimization complexes computational tool computational tools concern construction country COVID-19 COVID-19 omicron variant effective epitope Epitopes expression Final flexible Health Organization help highly antigenic Host IFN-γ immune mechanism immunogenic in-silico increasingly inducer initiative linker MEV MHC-II molecular molecular docking molecular dynamics mutagenic N-terminal non-allergenic non-toxic omicron Omicron variant overlapping peptide peptide-based planet Protein reverse vaccinology SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant Scientific community Simulation spike Spike protein stability suggested T-cell T-cell epitopes TLR TLR2 TLR4 TLRs toxic treat unique vaccination Vaccine vaccine candidate variant VoC WHO World Health Organization [DOI] 10.1016/j.virol.2022.05.001 PMC 바로가기 [Article Type] Article