TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokinesArticle Published on 2022-01-222023-06-18 Journal: Nature Immunology [Category] Fulltext, SARS, [키워드] β-Coronavirus COVID-19 Cytokine storm envelope protein ERK IFN-γ Inflammation Inflammatory cytokines MHV NF-κB SARS-CoV-2 TLR2 TNF-α [DOI] 10.1038/s41590-021-00937-x PMC 바로가기 [Article Type] Article
What triggers inflammation in COVID-19?Insight Published on 2022-01-202022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] COVID-19 Cytokine storm epithelial cell Inflammation Macrophage pro-inflammatory molecules SARS-CoV-2 Spike protein TLR2 Trigger viruses [DOI] 10.7554/eLife.76231 PMC 바로가기 [Article Type] Insight
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathwayResearch Article Published on 2021-12-062022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] abrogated activate Activation administration CCL2 chemokines co-cultured COVID-19 CXCL1 CXCL2 Cytokine storm elicited epithelial cell expressing S protein Extracellular Hyperinflammatory IFN IL-1β IL-6 induce Inflammation Inflammatory cytokine inflammatory function Inflammatory response investigated lung epithelial cell Macrophage macrophages mechanism membrane mice mouse macrophages NF-κB pathway nucleocapsid pathogenesis of COVID-19 potential therapeutic target produced Protein Proteins S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Spike protein stimulated structural protein the cytokine storm These data TLR1 TLR2 TLR6 TNF-α TNFα Trigger viruses wild-type [DOI] 10.7554/eLife.68563 PMC 바로가기 [Article Type] Research Article
A Combined Adjuvant TF–Al Consisting of TFPR1 and Aluminum Hydroxide Augments Strong Humoral and Cellular Immune Responses in Both C57BL/6 and BALB/c MiceArticle Published on 2021-11-292024-09-02 Journal: Vaccines [Category] 대상포진, [키워드] adjuvant combined adjuvant inbred mouse strains TFPR1 TLR2 [DOI] 10.3390/vaccines9121408 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection as a trigger of humoral response against apolipoprotein A-1SARS-CoV-2 감염은 Apolipoprotein A-1에 대한 체액 반응을 유발합니다.Article Published on 2021-11-012022-09-12 Journal: European Journal of Clinical Investigation [Category] MERS, SARS, 진단, [키워드] anti-apolipoprotein A-1 autoantibodies anti-SARS-CoV-2 anti-SARS-CoV-2 IgG association Autoimmune Autoimmunity bioinformatics Case-control clinical settings Cohort COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 prognosis cross-reactivity cytokine epitope Epitopes experiment experimental evidence General population healthy donor high-density homology humoral ICU Patients IgG IgG level immunoassay individual induce intensive care linear Lipoproteins molecular molecular mimicry peptide Prognosis prognostic Protein receptor SARS-CoV-2 SARS-COV-2 infection scrutiny sequence sequence homology seroconversion rate seronegative seropositive individual Significant spike Spike protein target the disease therapeutic TLR2 Toll-like receptor toll-like receptor 2. triggered were assessed were used [DOI] 10.1111/eci.13661 PMC 바로가기 [Article Type] Article
Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen전혈 전사 반응의 뚜렷한 패턴은 동일한 항원을 암호화하는 아데노 바이러스 및 poxviral 벡터 백신으로 예방 접종 후 마우스에서 유도된다.Research Published on 2021-10-302022-09-10 Journal: BMC Genomics [Category] MERS, SARS, 유전자 메커니즘, [키워드] adaptive immune responses Adenovirus Administered Analysis Antigen antigens cell activation cellular ChAdOx1 change changes characterisation Combination combinations Comparative analysis COVID-19 vaccine Diseases effective Emerging infectious diseases Epigenetic evaluate Express expression Gene Expression gene signature Genes greater heterologous prime-boost human clinical trial human clinical trials humoral immune response immune responses Infectious diseases innate immune involved Killer cell leads magnitude mechanism MHC class I mice natural killer natural killer cell Pathogens pathway Protective protective response protective responses Rapid induction regimen Regulation response Result significant enrichment single dose supplementary material T cell These data TLR2 transcriptional transcriptional response transgene type I interferon type I interferon genes Vaccine vaccine construct vaccine platform valuable resource vector vectors Viral Viral vector vaccine was used Whole blood [DOI] 10.1186/s12864-021-08061-8 PMC 바로가기 [Article Type] Research
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest우려 및 관심의 변이를 포함하는 SARS-CoV-2에 대항하는 백신의 효과적인 개발을 위한 잠재적인 다중 에피토프 구성을 설계하기 위한 심층 실리코 및 면역정보학 접근 방식Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Antibody titer antigenicity approach B cell B cell epitope B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.1 B.1.617.2 binding Cell cells coronavirus COVID-19 effective elevated epitope Health immune response Immunity immunoinformatics in silico in vitro linker linkers MEV Multi-epitope vaccine NK cells nucleotide nucleotide sequence ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 outbreak P.1 P.2 Pathogens Physicochemical properties polyprotein present Prevent preventive measure receptor S protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell epitope T-cell the vaccine TLR2 TLR4 Toll-like receptor Toll-like receptors turn utility Vaccine vaccine construct variants variants of concern variants of interest variants of SARS-CoV-2 viral pathogen were used [DOI] 10.1016/j.compbiomed.2021.104703 PMC 바로가기 [Article Type] Article
Babaodan controls excessive immune responses and may represent a cytokine-targeted agent suitable for COVID-19 treatmentBabaodan은 과도한 면역 반응을 제어하고 COVID-19 치료에 적합한 사이토카인 표적 제제를 나타낼 수 있습니다Article Published on 2021-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 치료법, [키워드] Activation adapter anti-cytokine storm anti-inflammatory activity approach Babaodan Bacterial Bacterial infection cellular Chinese contribute Control COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokines demonstrated determine evaluated excessive immune response IL-6 immune responses immunomodulatory in vivo increased survival indicated Inflammation inhibited Macrophage macrophages MAPK MAPK signaling mechanism mice molecular mouse model MYD88 NF-κB occur Occurrence overproduction Pathways Pneumonia pro-inflammatory cytokine pro-inflammatory cytokines protective role Protein recruitment reduction in responsible resulting reveal robust SARS-COV-2 infection Seven severe COVID-19 severely ill COVID-19 patients significantly TCM therapy TLR TLR2 TLR3 TLRs Traditional Chinese medicine transcriptomic treating COVID-19 Treatment TRIF viruses was used [DOI] 10.1016/j.biopha.2021.111586 PMC 바로가기 [Article Type] Article
C-type lectins and extracellular vesicles in virus-induced NETosisReview Published on 2021-06-112022-10-29 Journal: Journal of Biomedical Science [Category] COVID-19, MERS, SARS, [키워드] activate acute respiratory syndrome acute viral infections attenuate blockade C-type lectin C-type lectin receptor (CLR) caused CLEC10A CLEC2 CLEC5A Coagulopathy contribute Coronavirus-2 COVID-19 Cytokine storm danger signals DC-SIGN dengue virus Dengue virus (DV) disease severity ENhance EVs exacerbate Exosome Exosome (EXO) extracellular vesicle Extracellular vesicle (EV) facilitate glycan Inflammation inflammatory reactions intercellular Japanese L-SIGN microvesicle Microvesicle (MV) NET NETosis NETs neuronal Neutrophil extracellular trap organ Pathogenesis Patient pattern recognition receptor Platelet receptor reported responsible SARS-CoV-2 shown spleen stimulate TLR TLR2 tyrosine virus [DOI] 10.1186/s12929-021-00741-7 PMC 바로가기 [Article Type] Review
Glycyrrhizic Acid for COVID-19: Findings of Targeting Pivotal Inflammatory Pathways Triggered by SARS-CoV-2Pharmacology Published on 2021-06-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acid activate acute respiratory syndrome Anti-inflammatory Anti-inflammatory effects Anti-viral Antiviral Bioinformatics analysis Biological functions causative pathogen cellular Characteristics complement conducted coronavirus Coronavirus disease 2019 COVID-19 Cytokine storms enrichment analysis Factor Factors finding glycyrrhizic acid GO analysis growth factor Host ICAM1 identify IFN IL-17 IL-6 immune system indicated inflammatory pathway inflammatory pathways inhibit Interaction interactions mechanism miRNA MMP9 Mutation network analysis network pharmacology novel pathway Pathways predominant public health crisis reactive oxygen specy receptor signaling regulate SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly SOCS3 target targeted therapy targeting targets the cytokine storm therapeutic agent Therapies TLR2 TNF-α triggered Viral protein virus [DOI] 10.3389/fphar.2021.631206 PMC 바로가기 [Article Type] Pharmacology