Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19
Article
[키워드] activated
Algorithm
Analysis
APOC1
ApoE
BAL
BCL2A1
Bronchoalveolar lavage
Bronchoalveolar lavage (BAL)
C1QB
canonical
category
CCL2
CCL3
CCL5
CCL8
CCR1
Cell
cellular
chemotactic
chemotaxis
circulation
Clustering
Cohort
complex
coronavirus disease
correlation
COVID-19
CXCL8
Cytokine storm
dataset
diagnostic
disease severity
downregulated
EPSTI1
FABP4
FIVE
FPR1
functional
gene signature
gene signatures
hallmark
healthy subject
healthy subjects
ICGS2
identify
IFI27
IFI30
Ifi44
IFI44L
IFI6
IFIT1
IFIT3
IFITM1
IFITM2
IFITM3
IFNg
IL17
IL1A
IL1B
IL1RN
immune
Immune cell
Inflammatory
inflammatory macrophages
Inflammatory response
interstitial
iterative
KLF6
Macrophage
MALAT1
Mild
mononuclear cell
MX1
myeloid cells
NEAT1
neutrophil
Neutrophils
NFkB
OAS1
OAS2
OAS3
OASL
pathway
Patient
patients
PBMCs
Peripheral blood
phagocytes
phagocytosis
PLSCR1
PRL
reduction
reflected
role
S100A8
SARS-CoV-2
SAT1
several gene
severe COVID-19
severity
Signaling
Single Cell
SPP1
STAT3
subset
suppressed
systemically
TGM2
therapeutic interventions
TLR7
TLR9
TNF
TYMP
UMAP
upstream
with COVID-19
[DOI] 10.3390/cells9112374 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/cells9112374 PMC 바로가기 [Article Type] Article