Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfacesArticle Published on 2021-10-292022-10-31 Journal: Communications Biology [Category] COVID-19, MERS, SARS, [키워드] binding affinity Circular Contact de novo demonstrated domain domains inefficient Interaction motif Nanobiotechnology Particle Protein protein sequence Proteins Receptor binding domain repeated SARS CoV-2 significantly stability structures subunit subunits Topology trimeric viral neutralization X-ray crystallography [DOI] 10.1038/s42003-021-02766-y PMC 바로가기 [Article Type] Article
Local topology and bifurcation hot-spots in proteins with SARS-CoV-2 spike protein as an exampleResearch Article Published on 2021-09-302022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Alter amino acid fragment Analysis analyzed backbone candidate cause criteria D614G D614G substitution example expected identify introduced Local methodology N501Y novel outcome Protein Protein Data Bank proximal Research SARS-CoV-2 spike protein Spike protein the SARS-CoV-2 the spike protein Topology [DOI] 10.1371/journal.pone.0257886 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 adsorption on suspended solids along a sewerage network: mathematical model formulation, sensitivity analysis, and parametric studyResearch Article Published on 2021-09-172022-10-31 Journal: Environmental science and pollution research inter [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] accounting Adsorption applied approach competing Concentration distribution domain effort include independent variables mathematical modeling parameter performed physicochemical reduce resulting SARS-CoV-2 sensitivity analysis Sewerage network Specific Topology Treatment virus Virus concentration rationalization wastewater epidemiology [DOI] 10.1007/s11356-021-16528-0 PMC 바로가기 [Article Type] Research Article
Characterizing the roles of bots on Twitter during the COVID-19 infodemicResearch Article Published on 2021-08-302022-10-29 Journal: Journal of Computational Social Science [Category] COVID-19, [키워드] Algorithms amplification automated Bot caused cleavage Conspiracy theory COVID-19 COVID-19 pandemic diffusion Effect events examined favor indicate infodemic information misinformation outbreak proliferation Research social media supplementary material Topology [DOI] 10.1007/s42001-021-00139-3 PMC 바로가기 [Article Type] Research Article
Mitigating COVID-19 outbreaks in workplaces and schools by hybrid telecommutingResearch Article Published on 2021-08-262022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] Analysis Asymptomatic individuals Complete Contact coronavirus country COVID-19 COVID-19 epidemic COVID-19 outbreak develop effective Effectiveness Epidemic epidemicity Epidemics epidemiological feature France Guidance help include index case Interaction Intervention investigated Local mitigate outbreak pre-symptomatic provide public health random Reproduction number risk Rotation SARS-CoV-2 School Schools Spread super-spreaders threshold Topology Transmission Transmission model virus spread [DOI] 10.1371/journal.pcbi.1009264 PMC 바로가기 [Article Type] Research Article
Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2408 Published on 2021-08-242022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 40S acute respiratory syndrome application applied approach approaches atomic average binding site Cell cellular complex coronavirus determine domain Effectiveness full-length full-length protein generate highlight in-cell techniques information integrative modeling interactions mass spectrometry methodology Microscopy nucleocapsid nucleocapsid protein occur probe Protein Regulation residues reveal RNA SARS-CoV-2 sequence Significance structural biology Structure structures the N protein Topology Viral protein [DOI] 10.1073/pnas.2103554118 PMC 바로가기 [Article Type] 408
Deep geometric representations for modeling effects of mutations on protein-protein binding affinityResearch Article Published on 2021-08-042022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, [키워드] addition Amino acid approach binding affinity change dataset datasets deep develop drug design Effect effort ENCODE experiments feature functional geometric in silico Approach Interaction labor-intensive modeling Mutation mutations predict Protein protein complex Protein design protein-protein interaction Proteins RBD Research SARS-CoV-2 antibody structures the binding affinity the receptor-binding domain the S protein three-dimensional structure time-consuming Topology [DOI] 10.1371/journal.pcbi.1009284 PMC 바로가기 [Article Type] Research Article
LUNAR :Drug Screening for Novel Coronavirus Based on Representation Learning Graph Convolutional NetworkLUNAR : Representation Learning Graph Convolutional Network를 기반으로 한 신종 코로나바이러스에 대한 약물 스크리닝Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 신약개발, 치료제, [키워드] accelerate Affect automatically can be used candidate drug caused Characteristics clinical study complex Convolutional neural networks COVID-19 develop drug drug candidate drug candidates Drug development Effectiveness global pandemic graph heterogeneous heterogeneous networks in some information interpretability learning mechanism network novel Novel coronavirus outbreak outbreak of COVID-19 predict Predictive recall representation screened Screening selected speed strength suppress target targets Topology Treatment virus [DOI] 10.1109/TCBB.2021.3085972 PMC 바로가기 [Article Type] Article
One size fits all?: A simulation framework for face-mask fit on population-based facesResearch Article Published on 2021-06-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] age all subjects benefit CDC center cloth mask Control COVID-19 pandemic dependent on determine effective Efficacy examined expected Face mask facial gap opening Gender General population highlight Mask mitigate parameter prevention quantified resulting shown Spread subject Topology Transmission viral outbreak virus was used were used [DOI] 10.1371/journal.pone.0252143 PMC 바로가기 [Article Type] Research Article
Deciphering the laws of social network-transcendent COVID-19 misinformation dynamics and implications for combating misinformation phenomenaArticle Published on 2021-05-172022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] Analysis Applied mathematics central node combating Complex networks COVID-19 deep learning determine Evolution Health impacted implication Implications infodemic information Log-normal distribution mechanism media network analysis predict risk similarity Spread suppress Topology transfer triggered [DOI] 10.1038/s41598-021-89202-7 PMC 바로가기 [Article Type] Article