The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 micealpha/B.1.1.7 SARS-CoV-2 변이체는 ACE-2에 대해 훨씬 더 높은 친화성을 나타내며 K18-hACE2 마우스에서 질병을 유발하기 위해 더 낮은 접종 용량이 필요합니다Research Article Published on 2021-11-252022-09-10 Journal: eLife [Category] MERS, SARS, 변종, 진단, [키워드] a minor ACE-2 affinity Alpha angiotensin angiotensin-converting enzyme-2 anti-RBD Antibody neutralization asparagine B.1.1.7 B.1.1.7 variant convalescent individual convalescent individuals COVID-19 case disease Disease progression domination dose driven by elevated enzyme Epidemiology European exhibit faster functional hACE2 Human human Angiotensin-converting enzyme immunology incidence Infection K18-hACE2 mice low dose mice minor monoclonal antibodies mouse mouse model N501Y other variant other variants RBD Receptor-binding domain residue responsible SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant sera severity significantly higher Strains the receptor-binding domain transgenic transmission rate transmitted tyrosine United Kingdom variant Winter [DOI] 10.7554/eLife.70002 PMC 바로가기 [Article Type] Research Article
Cyclic 68 Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2Basic Science Investigation Published on 2021-11-012022-10-30 Journal: Journal of Nuclear Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 ARDS binding biodistribution calculated Cohort compounds Concentration coronavirus coronavirus disease COVID-19 COVID-19 patients cyclic detect detection generate glycol hACE2 half-maximal inhibitory concentration Human humanized hypothese identify identity inhibitor linear linker liver lung Lungs modulation murine murine model organ organ injury organ-specific peptide pet Pharmacologic reduction residues SARS-CoV-2 SARS-COV-2 infection small intestine Specific susceptibility transgenic transgenic model Visual was determined was used [DOI] 10.2967/jnumed.120.261768 PMC 바로가기 [Article Type] Basic Science Investigation
A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration강력한 이중특이성 나노바디는 비강 투여를 통해 SARS-CoV-2 감염으로부터 hACE2 마우스를 보호합니다Article Published on 2021-10-192022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration albumin alpaca bispecific circulating SARS-CoV-2 variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta delta variant effective Efficacy exhibit hACE2 hACE2 mice Human serum albumin immunized IMPROVE in vivo intranasal Live virus mice nanobody Nb15 Nb15-NbH-Nb15 neutralization potency Neutralizing potent neutralizing. Prophylactic PROTECT provide Pseudotyped viruses RBD of SARS-CoV-2 Receptor binding domain respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike glycoprotein therapeutic purpose therapeutic strategy transgenic treating COVID-19 Treatment trimer VHH wild-type [DOI] 10.1016/j.celrep.2021.109869 PMC 바로가기 [Article Type] Article
Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player of Host Defense and Immune RegulationImmunology Published on 2021-10-012022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] Acute inflammation biological function blunt cardiovascular diseases cardiovascular system Cell clearance conserved COVID-19 dead cells Diseases effector Evidence expression Factor healthy highlight homeostasis Host immune function immunopathology Infection infections Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory mediators Inflammatory response ischemic inflammation knock-out MCPIP-1 mechanism microbial microRNA miRNA monocyte mouse model mRNA neurodegenerative NFκB outlined Pleiotropic effects Protein public health recent Regulation Resolution signaling pathways stability syndrome target Therapeutic treatment tissue damage tissue injury tissue regeneration tissues transgenic viral infection virus [DOI] 10.3389/fimmu.2021.727861 PMC 바로가기 [Article Type] Immunology
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy생쥐에서 SARS-CoV-2 감염의 실시간 영상은 중화 항체가 최적의 효능을 위해 Fc 기능을 필요로 함을 보여줍니다Article Published on 2021-09-142022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Administered antibody applied bioluminescence imaging BLI Brain convalescent COVID-19 death Effect effective Efficacy Fab Fc effector functions Fc function function hACE2 highlight human ACE2 human ACE2 transgenic mice immune protection immunopathology in vivo indicated Infection Inflammatory response Inflammatory responses Interaction intranasally K18-hACE2 mice limit lung Lungs mechanism mice MONITOR Monocytes NAb NAbs nanoluciferase nasal Nasal cavity natural killer natural killer cell Natural killer cells neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils organ Pathogenesis prevented Prophylaxis required resolved reveal SARS-CoV-2 SARS-COV-2 infection subject systemically therapy transgenic treating COVID-19 Treatment virus spread [DOI] 10.1016/j.immuni.2021.08.015 PMC 바로가기 [Article Type] Article
Malaria-Resistant Mosquitoes (Diptera: Culicidae); The Principle is Proven, But Will the Effectors Be Effective?Article Published on 2021-09-072024-08-28 Journal: Annals of Medicine and Surgery [Category] 말라리아, [키워드] malaria Mosquito parasite Plasmodium transgenic
Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin국소 차아염소산(HOCl)은 UV에 노출된 SKH-1 고위험 마우스 피부에서 염증성 유전자 발현 및 종양 발생 진행을 차단합니다Article Published on 2021-09-012022-09-11 Journal: Redox Biology [Category] SARS, 유전자 메커니즘, [키워드] addition Analysis AP-1 atopic dermatitis bioluminescent block blocked Cancer Carcinogenesis clinical evidence combinations condition consequence COVID-19 pandemic drinking water elicited environmental exposure example exposure to finding Gene Expression Gene expression analysis high risk HMOX1 HOCl hypochlorous acid Il19 Immunohistochemical analysis Inflammation Inflammatory inflammatory signaling investigated luciferase mice mimicking modulation molecular murine model NOS2 observation oxidative stress oxidizing Pathway-focused gene expression profiling performed progression psoriasis PTGS2 public health Radiation reconstructed released skin skin cancer Solar Solar UV radiation. Srxn1 Stress stress response subsequent Support suppressed suppression Swimming pool therapeutic therapeutic intervention These data TLR4 Topic topical transgenic ultraviolet water [DOI] 10.1016/j.redox.2021.102042 PMC 바로가기 [Article Type] Article
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다Research Article Published on 2021-07-162022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic [DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article
Combating Human Viral Diseases: Will Plant-Based Vaccines Be the Answer?Review Published on 2021-07-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome addressed agroinfiltration animal model clinical trials communicable Coronavirus-2 Critical Culture emergency response Epitopes expressing expression genetic engineering HBV HCV Health Hepatitis B virus hepatitis C virus HIV Host HPV Human Human immunodeficiency virus human papillomavirus impacted Influenza virus molecular monoclonal antibodies pandemic performed plant plant cell plant-derived vaccine produced progressed proportions Recombinant protein respiratory virus SARS-CoV-2 shown transgenic transient expression Vaccine Vaccines Viral antigen viral disease Viral diseases virus Virus-like particle VLPs [DOI] 10.3390/vaccines9070761 PMC 바로가기 [Article Type] Review
The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent MannerArticle Published on 2021-06-032022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACE2 acute lung injury acute respiratory distress acute respiratory syndrome AKT ALI ARDS Betacoronavirus Calu-3 Cell characterized chemokine chemokines CXCL9 contribute contributing to coronavirus Coronavirus disease 2019 COVID-19 CXCL10 CXCL11 CXCL9 cytokine Cytokine storm cytokines IL-6 develop elevated enzyme epithelial cell feature Gene Expression GSK690693 hACE2 mice human lung hyperinflammation IFN-γ IL-6 immunostimulatory include increase in increases in infected with SARS-CoV-2 inflammatory state inhibitor kinase lung mechanical ventilation mice overexpression pandemic pathway positive individual pro-inflammatory pulmonary complication reduced reducing responsible RNA virus Sample SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 Signaling signaling pathway significantly small molecule inhibitor syndrome target TNFα transcript Transcription transgenic Treatment upregulation were used [DOI] 10.3390/v13061062 PMC 바로가기 [Article Type] Article