Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped virusesArticle Published on 2022-08-012022-11-15 Journal: Phytotherapy research : PTR [Category] SARS, 치료제, [키워드] ACE2 receptor ADA Antiviral antiviral activity antivirals antivirals. approach blocked caused complementary COVID-19 pandemic death drug candidate effective drugs evaluated H5N1 HIV-1 Host indicated inhibited inhibitor inhibitory activity plant pseudotyped pseudovirus responsible Safe SARS-CoV-1 SARS-CoV-1 and 2 SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoVs Spatholobus suberectus Dunn target cell Toxicity treating COVID-19 Treatment viral entry virus viruses [DOI] 10.1002/ptr.7452 PMC 바로가기
Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment [DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article
Variations of SARS-CoV-2 in the Iranian population and candidate putative drug-like compounds to inhibit the mutated proteinsResearch article Published on 2022-07-112022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] addition Affect antibody appear Ardabil benefit Candidate putative drug-like compounds Ciclesonide complex Compound conserved COVID-19 diagnosing DNA docked element Evolution Frame Genetic Genetic variant help indels indicated inducer Infection inhibit inhibitor Interaction Iran mechanism of action Meta-analysis mutated Mutation Nonstructural proteins (NSPs) Novel coronavirus NSP8 nucleotide nucleotide mutation Open reading frame (ORF) ORF1ab Orf9b Oxford polyproteins Potential Protein reported responsible resveratrol SARS-CoV-2 SARS-CoV-2 gene sequence sequenced Spread Substitution the SARS-CoV-2 Topic treating COVID-19 Vaccine design Viral proteins viral replication virus Wuhan, China [DOI] 10.1016/j.heliyon.2022.e09910 [Article Type] Research article
Cost-Effectiveness Analysis of Molnupiravir Versus Best Supportive Care for the Treatment of Outpatient COVID-19 in Adults in the US미국 성인의 코로나19 외래환자 치료를 위한 몰누피라비르 대 최상의 지지 요법의 비용 효율성 분석Article Published on 2022-07-012022-09-11 Journal: PharmacoEconomics [Category] MERS, 바이오마커, 변종, [키워드] acute phase adult outpatient adult outpatients Adult patients affected Analysis Antiviral best Care changes changes in conducted coronavirus disease Coronavirus disease 2019 Cost effectiveness COVID-19 COVID-19 outpatients database de novo Decision tree decrease died dominant effective Electronic health record Electronic health records evaluated healthcare Healthcare system highest Hospitalization Hospitalized Immunity increase in information Intervention less Markov medical costs Mild-to-moderate molnupiravir outcome Outpatient pandemic parameter Patient patient population Perspective Primary outcomes Probability progression proportion real-world data reduction remained reported Research risk sensitivity analysis severe disease Society supportive care Therapies threshold transition transition probabilities treated treating COVID-19 Treatment Trial unavailability utility vaccination Viral Viral variants with COVID-19 [DOI] 10.1007/s40273-022-01168-0 PMC 바로가기 [Article Type] Article
The naturally-derived alkaloids as a potential treatment for COVID-19: A scoping reviewCOVID-19의 잠재적 치료제로서의 천연 유래 알칼로이드: 범위 검토Review Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] activities acute respiratory syndrome coronavirus alkaloids Anti-inflammatory Antiviral applicability assessments berberine binding energy caused cephaeline clinical trial clinical trials Colchicine coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 database described Effects eligible Emetine Ergotamine high mortality rate homoharringtonine in silico in vitro Inflammatory marker inflammatory markers inhibit knowledge lycorine medicinal plant narciclasine natural product new treatment strategy observational studies papaverine pharmacological plant Potential treatment Protein target protein targets Quinine reduce respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 target proteins Therapeutic compounds Transmissibility treating COVID-19 variety was performed [DOI] 10.1002/ptr.7442 PMC 바로가기 [Article Type] Review
Efficacy and Safety of Lianhua Qingwen for Patients with COVID-19: A Systematic Review and Meta-AnalysisCovid-19 환자를위한 Lianhua Qingwen의 효능 및 안전성 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-012022-08-31 Journal: Chinese journal of integrative medicine [Category] 치료제, [키워드] 2019-nCoV Adverse reaction Analysis China Chinese Chinese medicine Computed tomography conducted control group Corona virus cough COVID-19 Data analysis database disease drug effective Efficacy and safety evaluate expectoration experimental group Express fatigue Fever followed by Intervention lianhua qingwen measure Meta-analysis nCoV outbreak outcome measures participant Randomized controlled trial Randomized controlled trials RCT RCTs researchers respiratory Retrospective study review risk of bia Safety scale Shortness of breath Spread subgroup analysis Symptoms systematic review treat treating COVID-19 treating COVID-19 patient Treatment treatment methods Trial trials Virus Disease was used were assessed with COVID-19 [DOI] 10.1007/s11655-022-3578-8 PMC 바로가기 [Article Type] Meta-Analysis
A novel property of hexokinase inhibition by Favipiravir and proposed advantages over Molnupiravir and 2 Deoxy D glucose in treating COVID-19Favipiravir에 의한 헥소키나아제 억제의 새로운 특성 및 COVID-19 치료에서 Molnupiravir 및 2 Deoxy D 포도당보다 제안된 이점Article Published on 2022-07-012022-09-11 Journal: Biotechnology letters [Category] COVID19(2023년), SARS, 치료제, [키워드] 2 Deoxy D glucose activity affected antiviral drug Concentration COVID-19 Cyan Ebola exhibited Favipiravir flu Glucose Health Hexokinase Host inhibiting Inhibition assays molecular docking molecular docking studies molnupiravir Remdesivir SARS-CoV-2 shown Spread supported treat treating COVID-19 treatment regimen Trial trials wake [DOI] 10.1007/s10529-022-03259-6 PMC 바로가기 [Article Type] Article
Herbal medicine for COVID-19: An overview of systematic reviews and meta-analysisReview article Published on 2022-07-012022-10-05 Journal: Phytomedicine : international journal of phytother [Category] 임상, [키워드] addition benefit caused clinical study coronavirus disease COVID-19 critical appraisal database Effect effective Effectiveness Efficacy eight Evidence group had no herbal medicine indicated Intervention measurement medication Meta-analysis methodological Methodological quality nine nonrandomized outbreak outcome overlap pandemic Randomized controlled trial RCTs researcher Result retrieved searched selected Spread systematic review therapy Traditional Chinese medicine treating COVID-19 Treatment treatments for COVID-19 Trial Volume was used [DOI] 10.1016/j.phymed.2022.154136 [Article Type] Review article
Ivermectin for preventing and treating COVID-19COVID-19 예방 및 치료를 위한 이버멕틴Review Published on 2022-06-212022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission adverse event adverse events all-cause mortality antiparasitic Antiviral approach ARMS Asymptomatic certainty certainty of evidence citation classification Clinical improvement clinical trial Cochrane COVID-19 Study Register coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 symptoms COVID-19 treatment Data collection database death discharged disease disease severity double-blind duration of symptom early stage early stages Efficacy Efficacy and safety eligible Evidence excluded for inclusion GRADE hospital identify in vitro include increase index Infection infection with SARS-CoV-2 inhibit inhibitory effect initial symptom Inpatient Inpatients Intervention Invasive mechanical ventilation investigated Ivermectin life mean difference Mental Meta-analysis Mild Moderate COVID-19 moderate-to-severe COVID-19 molecular hypothesis Mortality no effect non-randomized ongoing trial ongoing trials Open-label outcome Outpatient outpatients participant Participants people with COVID-19 physical Placebo placebo-controlled Postexposure Prophylaxis Prevent Quality of life question Randomized controlled trial Randomized controlled trials RCT RCTs receiving reduce Registered Replication Reporting request Research resolved risk Risk of bias risk ratio RoB 2 SARS-CoV-2 SARS-COV-2 infection Science Citation Index searched Selection Serious Adverse Event Serious Adverse Events Seven severe acute respiratory syndrome Coronavirus Standard of care treat treated treating COVID-19 Treatment Trial trials viral clearance virus Web of Science WHO WHO guideline worsening [DOI] 10.1002/14651858.CD015017.pub3 PMC 바로가기 [Article Type] Review
The COVID-19 pandemic – what have urologists learned?COVID-19 전염병 - 비뇨기과 전문의는 무엇을 배웠습니까?Review Published on 2022-06-012022-09-11 Journal: Nature reviews. Urology [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, [키워드] ACE2 Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting AKI androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused cell damage changes in clinical study Complication complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic damage Deprivation Economy expressed genitourinary tract high risk hypogonadism impairment in urine Invasion organ organs outbreak pandemic patients with COVID-19 public health raising receptor reported respiratory tract SARS-CoV-2 secondary hypogonadism Semen severe acute respiratory syndrome Coronavirus spermatogenesis survival Symptom testes Testosterone the WHO therapy tract treating COVID-19 Urine [DOI] 10.1038/s41585-022-00586-1 PMC 바로가기 [Article Type] Review