Dietary supplements to reduce symptom severity and duration in people with SARS-CoV-2: study protocol for a randomised, double-blind, placebo controlled clinical trialSARS-CoV-2 환자의 증상 중증도 및 기간을 줄이기 위한 식이 보조제: 무작위, 이중 맹검, 위약 대조 임상 시험을 위한 연구 프로토콜Article Published on 2022-03-032022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] Analysis approach approval approved assessment Canada capture case report form caused clinical trials college Community complementary complementary medicine Controlled clinical trial Controlled trial COVID-19 COVID-19 test death diagnosed with COVID-19 dietary double-blind effective Efficacy Ethical approval Ethics feasibility Frequency Health Health Canada Health status herd immunity hospitalisation hospitalisations Immunity include independent mean score mean scores Medicine monitoring board morbidity Mortality natural network Open Access Outpatient outpatients parallel-group Patient peer-reviewed Placebo placebo-controlled platform Primary outcome product randomised randomised controlled trial recorded recruited reduce registration number Regulatory Research Research Ethics Result Science secondary outcome Secondary outcomes Study protocol symptom severity t tests Treatment Two-arm underlying condition underlying conditions vaccination Vaccine vaccine efficacy Vaccine hesitancy Visual Vitamin C Vitamin D vitamin K Zinc [DOI] 10.1136/bmjopen-2021-057024 PMC 바로가기 [Article Type] Article
Randomized, Double Blind, Placebo Controlled, Clinical Trial to Study Ashwagandha Administration in Participants Vaccinated Against COVID-19 on Safety, Immunogenicity, and Protection With COVID-19 Vaccine–A Study ProtocolMedicine Published on 2022-02-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] administration Against All adverse event antibody titres approval Ashwagandha Ayurveda benefit clinical commenced Controlled COVID-19 COVID-19 infection COVID-19 vaccine double-blind effective Ethics exploratory study healthy volunteer immunoadjuvant immunogenicity immunological India Indian people interim analysis margin Measures Medicine National offered outcome measure Oxford-AstraZeneca parallel-group participant peer-reviewed placebo-controlled populations power calculation protection protective immune response Quality of life Randomized RBD-specific IgG receiving recruited recruitment regimen Registration reported Result Safety SARS-CoV-2 spike second dose secondary Two-arm vaccinated against COVID-19 vaccination Vaccine was obtained Withania somnifera [DOI] 10.3389/fmed.2022.761655 PMC 바로가기 [Article Type] Medicine
Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial확인 된 또는 의심되는 박테리아 감염 (Batch)으로 입원 한 어린이의 바이오 마커 유도 항생제 치료 기간 : 무작위 대조 시험을위한 프로토콜Paediatrics Published on 2022-01-252022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 바이오마커, 임상, [키워드] Adverse drug reactions adverse effect Algorithm Analysis Antibiotic treatment antibiotic use Antibiotics approved Bacterial infection best Biomarker C reactive protein children clinician commenced conducted conjunction control arm Controlled COVID-19 pandemic death Diagnostic microbiology discharge dissemination East Ethics Follow-up Health hospital Hospital stay HRA include infections Infectious diseases International Intervention intravenous antibiotics National Health Service NHS North outcome paediatric intensive & critical care PCT peer-reviewed procalcitonin protocol public health randomised controlled trial RCT REC recruit reduce registration number Relapse Research respond Safety measure secondary Secondary outcomes treated Treatment trial protocol Two-arm utility West [DOI] 10.1136/bmjopen-2020-047490 PMC 바로가기 [Article Type] Paediatrics
A first remotely-delivered guided brief intervention to reduce intrusive memories of psychological trauma for healthcare staff working during the ongoing COVID-19 pandemic: Study protocol for a randomised controlled trialArticle Published on 2022-01-122022-10-04 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] 1:1 cognitive consequence COVID-19 COVID-19 pandemic develop digital intervention dissemination event finding flexible groups healthcare Healthcare staff include Inclusion Intervention Intrusive memories memory mental health mitigate outcome pandemic Placebo post-intervention Primary outcome protocol Psychological Psychological trauma psychologically randomised controlled trial Randomly RCT receive reduce reported researcher risk Support Symptoms trauma Two-arm Week [DOI] 10.1016/j.conctc.2022.100884 PMC 바로가기 [Article Type] Article
Impact of COVID-19 on Infertility Treatments: Not Even a Global Pandemic Was Strong Enough to Hamper Successful PregnanciesArticle Published on 2021-12-212022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Affect clinically clinics coronavirus correlation COVID-19 Enough Final global pandemic Hamper Impact infertility infertility treatments negatively affected outcome pandemic performed Pregnancy pregnant pregnant women proportion Psychological reduction in retrospective Rome Spain Strong study population translated Treatment Two-arm women [DOI] 10.3390/life12010006 PMC 바로가기 [Article Type] Article
Update to the study protocol for an implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation중증 COPD 악화 환자의 비침습적 인공호흡 개선을 위한 두 가지 교육 전략을 비교하는 시행-효과 시험을 위한 연구 프로토콜 업데이트Update Published on 2021-12-162022-09-10 Journal: Trials [Category] 임상, [키워드] acceptability addition baseline Care changed changes in Cluster Cohort complex COPD COVID-19 pandemic demonstrated Effectiveness effort Evidence feasibility hospital hospitals implementation IMPROVE initial Intervention morbidity and mortality MOST NIV Noninvasive ventilation outcome outlined Patient patients patients hospitalized Pragmatic Primary outcome proportion provided Randomized recruitment respiratory second seriously ill patients statistical analysis Study design Study protocol suggested target therapy Trial Trial registration Two-arm Variation [DOI] 10.1186/s13063-021-05855-9 PMC 바로가기 [Article Type] Update
Clinical and cost-effectiveness of a New psychosocial intervention to support Independence in Dementia (NIDUS-family) for family carers and people living with dementia in their own homes: a randomised controlled trialRandomized Controlled Trial Published on 2021-12-022022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] Affect attainment behavioural benefit Care clinical clinical trial component Controlled COVID-19 COVID-19 pandemic Dementia demonstrated determine distress dyad evaluate the effect exacerbate facilitator Family carer Follow-up Goal Health implementation improvement include Increasing Independence initial Intervention intervention group knowledge management MOST New number offered professional Psychosocial intervention randomised randomised controlled trial receive recruitment Scaling selected Standard Stress Support supported Trial Two-arm usual care usual care alone [DOI] 10.1186/s13063-021-05851-z PMC 바로가기 [Article Type] Randomized Controlled Trial
Improving precision and power in randomized trials for COVID-19 treatments using covariate adjustment, for binary, ordinal, and time-to-event outcomes공변량 조정을 사용하여 이항, 순서 및 사건 발생까지의 시간 결과에 대한 COVID-19 치료에 대한 무작위 시험의 정밀도 및 검정력 향상Article Published on 2021-12-012022-09-11 Journal: Biometrics [Category] SARS, 임상, [키워드] added Analysis approach center clinical trials ClinicalTrials Control covariate covariate adjustment COVID-19 COVID-19 treatment disease control distribution drug Drug administration essence European Medicines Agency food hypothetical implementation IMPROVE Improving Inference Longitudinal data Medicine New York ordinal outcomes outcome Participants patients hospitalized Phase 2 Precision prevention prevention of COVID-19 Primary outcome R package Randomized randomized clinical trial randomized trial randomized trials recommendation reduce reductions in Registered required Sample size sample sizes Standard of care statistical analysis survival survival analysis targets time Treatment treatment trials treatments for COVID-19 Trial trials Two-arm U.S. Food and Drug Administration variety [DOI] 10.1111/biom.13377 PMC 바로가기 [Article Type] Article
Clinical efficacy of COMPASS, a digital cognitive-behavioural therapy programme for treating anxiety and depression in patients with long-term physical health conditions: a protocol for randomised controlled trial장기 신체 건강 상태를 가진 환자의 불안과 우울증을 치료하기 위한 디지털 인지-행동 치료 프로그램인 COMPASS의 임상 효능: 무작위 대조 시험을 위한 프로토콜Article Published on 2021-10-252022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 access All participant All participants allocation concealment analysed Anxiety anxiety disorders approved baseline blinded to treatment clinical Clinical efficacy clinical trials collected college COMPASS conducted conferences confidence consequence Controlled trial COVID-19-related distress data analyst Depression depression & disorders distress Efficacy eligible Ethics evaluate finding FIVE Health health condition healthcare services independent individual Informed consent intention-to-treat principle interview King knowledge life London LTC LTCs mental health problem mental health problems Midwifery mood disorders National Nursing parallel-group participant Patient peer-reviewed physical Primary outcome protocol Psychological distress psychological treatment Quality of life Qualtrics randomisation randomised controlled trial Randomly receive recruited reducing registration number Research Ethics scale SCS secondary outcome Secondary outcomes Self-management Support symptom severity therapy Treatment treatment allocation Two-arm [DOI] 10.1136/bmjopen-2021-053971 PMC 바로가기 [Article Type] Article
Intervening on Trust in Science to Reduce Belief in COVID-19 Misinformation and Increase COVID-19 Preventive Behavioral Intentions: Randomized Controlled TrialRandomized Controlled Trial Published on 2021-10-142022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] 95% CI adjusted odds ratio Affect age aggregate analyses approach assigned belief collected contribute Controlled covariate COVID-19 develop Evidence examined Gender Identifier increase increase in indirect effect infodemic Intention intervene Intervention intervention effect misinformation objective outcome parallel-group participant pilot study platform Prevent Prolific Randomized controlled trial Randomly RCT recruit reduced Registration report Research Result Science The effect size Trust trust in science turn Two-arm [DOI] 10.2196/32425 PMC 바로가기 [Article Type] Randomized Controlled Trial