type I interferons – Page 3 – Communicable Diseases Research

Pre-existing Autoantibodies Neutralizing High Concentrations of Type I Interferons in Almost 10% of COVID-19 Patients Admitted to Intensive Care in Barcelona

바르셀로나에서 집중 치료에 입원한 COVID-19 환자의 거의 10%에서 고농축 I형 인터페론을 중화하는 기존 자가항체

Article

Published on 2021-11-012022-09-12
Journal: Journal of Clinical Immunology [Category] MERS, SARS, 진단,

Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics

Research Article

Published on 2021-10-252022-10-28
Journal: PLoS Computational Biology [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis antiviral response Cell Cell culture coefficients condition coronavirus COVID-19 cultures cytokine cytokine signaling Cytokine storm diffusion drug candidates early stage epithelial evaluated evidenced excessive inflammation exhibit experiment Factor flu form growth H1N1 influenza H3N2 help highlight immune immune response immunopathology IMPROVE in some in vitro include induce Infection inflammatory condition Inflammatory response Influenza inhibit innate immune response interferon interferon response interferon signaling interferons involved JAK/STAT pathway lesion linear local concentration lung lung cell Lung epithelial cells Lung infection Lungs manifestation mechanism molecular multicellular Occurrence pandemic Pandemics parameter pathway performed plaque plaques protective effect public health radial growth Replication respiratory Respiratory disease respiratory infection responsible reveal RNA virus RNA viruses SARS-CoV-2 severe cases severe inflammation severity Signaling signaling molecule Spanish the disease tissue Treatment Trigger type I interferons understanding Variation viral growth Viral load viral replication virus virus-infected cell
[DOI] 10.1371/journal.pcbi.1008874 PMC 바로가기 [Article Type] Research Article

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia

X-연관 TLR7 결핍은 운동실조-모세혈관확장증 남성 환자의 심각한 COVID-19 폐렴의 원인이 됩니다

Case Reports

Published on 2021-10-232022-09-10
Journal: Journal of Clinical Immunology [Category] MERS, 변종, 유전자 메커니즘, 치료기술,

[키워드] antibody Antibody deficiency Asymptomatic Ataxia ataxia-telangiectasia ATM autoantibodies autoantibody candidate gene clinical manifestations conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 immune response COVID-19 pneumonia Critical critical COVID-19 deficiencies deficiency Deleterious Diagnosis disease evaluated exhibit Exome genetic cause genetic defect genetic defects high risk homozygous identify IFNs IgM immune response Immunity Impact inborn errors of immunity individual interferons investigated life-threatening mechanism Mild symptom mild symptoms Mutation neurological signs objective Patient patients evaluated Pneumonia Primary Immunodeficiency radiosensitivity Result SARS-COV-2 infection Sequencing serum levels specific antibodies specific antibody supplementary material syndrome telangiectasia the patient TLR7 TLR7 gene Treatment Type I IFN type I interferon type I interferons underlie understanding unique variant virus was performed were measured
[DOI] 10.1007/s10875-021-01151-y PMC 바로가기 [Article Type] Case Reports

An Update on Innate Immune Responses during SARS-CoV-2 Infection

SARS-COV-2 감염 동안 타고난 면역 반응에 대한 업데이트

Review

Published on 2021-10-142022-09-10
Journal: Viruses [Category] MERS, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral cellular receptor cellular receptors characterized components Coronaviridae family coronavirus COVID-19 pandemic Cytokines Defense disrupt Effect followed by Host hypersecretion IFN-α/β IFNs immune dysfunction immune responses Innate innate immune innate immune response innate immune responses innate immune system interferons invading pathogen invading pathogens member Mortality organ injury Pathogens patients with COVID-19 potential therapeutic targets pro-inflammatory cytokines protease respiratory response responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling the Coronaviridae Type I IFN type I interferon type I interferons variety Viral
[DOI] 10.3390/v13102060 PMC 바로가기 [Article Type] Review

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다

Research Article

Published on 2021-09-222022-09-10
Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons
[DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article

Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings

바이러스 감염 중 I 형 인터페론 유도 및 피로

Review

Published on 2021-09-152022-09-10
Journal: Viruses [Category] SARS, 바이오마커,

[키워드] 2019 coronavirus disease antiviral cytokine antiviral cytokines antiviral immunity Autoimmunity breadth compromise coronavirus coronavirus disease COVID-19 cytokine Cytokines DCs dendritic cell dendritic cells Exhaustion family favor finding focus HBV HCV HIV-1 IFN-I immunopathology induce induction Infection Influenza innate response interferons isoform LCMV less mechanism opportunistic Infections pandemic pDC pDCs plasmacytoid dendritic cells producing reduced referred to SARS-CoV-2 secrete Stimulation susceptibility sustained Type type I interferons Viral viral infection viral persistence viral replication while
[DOI] 10.3390/v13091839 PMC 바로가기 [Article Type] Review

Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90

SARS-CoV-2 Orf9b의 인산화는 TOM70의 2개 결합 부위에 대한 표적화 및 Hsp90 모집을 조절합니다

Article

Published on 2021-08-262022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association B.1.1.7 binding binding site C-terminal domain cascade causative agent chaperone chaperones characterized complex coronavirus COVID19 decrease domain ENCODE expression Glutamate Hsp90 IFN-I indicate infected cells inhibit interferon interferons involved leads mechanism Mitochondria mitochondrial mitochondrial outer membrane N-terminal N-terminal domain Orf9b pandemic Phosphorylation position Protein Proteins recruitment reduced regulated respiratory SARS-CoV-2 SARS-CoV-2 genome Serine severe acute respiratory syndrome Coronavirus Signaling Site target targeting TOM70 TPR type I interferon type I interferons variant variant of concern Viral Viral protein
[DOI] 10.3390/ijms22179233 PMC 바로가기 [Article Type] Article

Cutaneous Adverse Reactions to COVID-19 Vaccines: Insights from an Immuno-Dermatological Perspective

Review

Published on 2021-08-252022-10-28
Journal: Vaccines [Category] COVID-19,

Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model

비강 내 I형 인터페론 치료는 SARS-CoV-2 햄스터 모델에서 임상 징후가 발병하기 전에 투여할 때만 유익합니다.

Research Article

Published on 2021-08-092022-09-10
Journal: PLoS Pathogens [Category] SARS, 치료제,

[키워드] Administered administration Antiviral caused Clinical course Clinical sign clinical trial clinical trials COVID-19 patients days post-infection Deleterious deleterious effects demonstrated disease Effect effector Efficacy and safety Evidence had no Host IFN-α IFNs immunopathology Impaired Infection information interferon interferons Intervention intranasal lung titers MERS MERS-CoV mice modulate observation onset of symptom onset of symptoms patients Post-infection preclinical study produced provide provided SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown Signaling Stage the SARS-CoV-2 the timing Therapeutics Treatment Type Type I IFN type I IFNs type I interferon type I interferons Viral viral infections weight loss
[DOI] 10.1371/journal.ppat.1009427 PMC 바로가기 [Article Type] Research Article

Long Noncoding RNAs as Emerging Regulators of COVID-19

COVID-19의 새로운 조절자로서의 긴 비코딩 RNA

Review

Published on 2021-08-022022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제,

[키워드] (Tocilizumab) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral immune response antiviral immune responses antiviral role biological processe biological processes cellular changes in Clinical treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 treatment death Dexamethasone disease drug Evidence expression glucocorticoid Glucocorticoids help Host host transcriptome immune dysfunction Immune escape immune responses incidence rate indicate Infection Inflammatory response inhibiting interferons involved lncRNA lncRNAs Long long noncoding RNA mechanisms monoclonal antibodies monoclonal antibody Occurrence pandemic pathology regulate Regulation regulator Research respiratory resulting RNA SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread subsequent therapeutic thrombosis Tocilizumab Transcriptome Treatment type I interferon type I interferons up-regulate Viral viral gene viral genes viral infections viral replication virus infection virus infections
[DOI] 10.3389/fimmu.2021.700184 PMC 바로가기 [Article Type] Review