Current trends in COVID-19 diagnosis and its new variants in physiological fluids: Surface antigens, antibodies, nucleic acids, and RNA sequencingReview article Published on 2022-12-012022-10-05 Journal: TrAC Trends in Analytical Chemistry [Category] 바이오마커, 변종, 진단, 치료기술, [키워드] addressed antibodies antibody Antigen antigens Beta Biomarker biosensors Blood body fluid circulation clustered regularly interspaced short palindromic repeats COVID-19 COVID-19 diagnosis COVID-19 virus diagnosis CRISPR Critical current Delta Detection sensitivity diagnostic early stage ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Gamma Infection isothermal amplification lateral flow immunoassay LFIA limit Loop-mediated isothermal amplification microarray analysis Microarray assays Mutation nucleic acid nucleic acids omicron outbreak overcome palindromic repeat physiological provide Rapid reduce reverse transcriptase-polymerase chain reaction reverse transcription RNA sequencing RT-LAMP RT-PCR Saliva SARS-CoV-2 Semen specificity Spread surface Urine variant variants virus viruses [DOI] 10.1016/j.trac.2022.116750 [Article Type] Review article
Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular MechanismsArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] 신약개발, 진단, [키워드] accompanied activity addition aging all-cause mortality animal model animal models available data benefit Biomarker blunt caloric restriction calories cardiovascular diseases Cardiovascular outcomes cellular senescence clinical study clinical trials Compound COVID-19 decrease diabetes driver drug drugs employment Evidence Fatty acid feature Glucose heart failure humans IL-6 independent inflammaging Inflammasome inhibitor inhibitors intrinsic Kidney disease low-grade inflammation Meta-analysis modulating modulation molecular Mortality nutrient-sensing pathways observational studies outcomes pathway Patient promote provided repurposing selected senescence sodium-glucose cotransporter 2 inhibitors. substrates suggested Support systemic effects systemic level target Urine [DOI] 10.3390/ijms232012325 PMC 바로가기
Changes in the urinary proteome before and after quadrivalent influenza vaccine and COVID-19 vaccinationArticle Published on 2022-10-072023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] COVID–19 proteome QIV Urine vaccination [DOI] 10.3389/fimmu.2022.946791 PMC 바로가기
Treatment retention, return to use, and recovery support following COVID-19 relaxation of methadone take-home dosing in two rural opioid treatment programs: A mixed methods analysisResearch article Published on 2022-10-012022-10-05 Journal: Journal of substance abuse treatment [Category] 치료법, [키워드] Abuse Analysis association change clinically COVID-19 dose doses Effect EHR employment expected feasible FIVE Health increase in individual less Medication for opioid use disorder Methadone objective opioid Opioid treatment OTP Patient patients positive positive result Probability Program promoted public health Qualitative qualitative analysis Quantitative reaction reduced regimens Regression model Result rural service substance Support supported Travel Treatment triggers Urine [DOI] 10.1016/j.jsat.2022.108801 [Article Type] Research article
Features of the Humoral Response to Infection, Vaccination, and Revaccination during COVID-19Article Published on 2022-10-012022-11-15 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody antibody levels Antigen Blood coronavirus COVID-19 Gam-COVID-Vac Gam-COVID-Vac vaccine Humoral immunity IgG antibody IgM IgM antibodies IgM antibody majority medium observation period Patient recovered patients Registered response revaccination S-protein SARS-CoV-2 sera serum subject the disease the SARS-CoV-2 virus Urine vaccination virus-neutralizing [DOI] 10.1007/s10517-022-05620-1 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Antigen in Urine of Hospitalized Patients With Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] absence Accuracy acute respiratory syndrome Admission antibodies Blood C-reactive protein Compound coronavirus coronavirus 2 coronavirus disease Course COVID-19 disease severity dissemination early phase hospitalized patient immunoassay Infection intensive care units lactate dehydrogenase lymphopenia marker nucleocapsid nucleocapsid antigen Patient patients hospitalized patients with SARS-CoV-2 plasma polymerase chain positive reflect respiratory SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 nucleocapsid severe COVID-19 severity Severity of disease tested urinary Urine [DOI] 10.1093/infdis/jiac073 PMC 바로가기
Effect of Coronavirus Disease (COVID-19) on Human Semen: No Evidence of Coronavirus in Semen of PatientsArticle Published on 2022-09-122022-11-15 Journal: BioMed Research International [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addition Analysis analyzed Blood both group China clinical recovery Concentration coronavirus COVID-19 disease Effect evaluate evidence of fertile Human men morphology no significant difference organs Oropharyngeal parameter Patient PCR test secreted Semen shown significantly lower specimen tested two groups Urine viability virus was done with COVID-19 [DOI] 10.1155/2022/6204880 PMC 바로가기
t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and SeverityArticle Published on 2022-09-032022-11-15 Journal: Biomolecules [Category] SARS, 바이오마커, 변종, [키워드] addition Alter Biomarker candidate cellular RNA changes in COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients elevated Extracellular Infection LC-MS modified nucleosides. nucleoside nucleosides RNA SARS-CoV-2 searched serum severity Strong symptom severity Urine variants [DOI] 10.3390/biom12091233 PMC 바로가기
Infliximab in the treatment of patients with severe COVID-19 (INFLIXCOVID): protocol for a randomised, controlled, multicentre, open-label phase II clinical studyArticle Published on 2022-09-022022-10-04 Journal: Trials [Category] SARS, 임상, 진단, [키워드] 28-day mortality addition Affect Alpha approved assessment Blood changes chronic inflammatory disease clinical study clinical trial collected Course COVID-19 current therapy dose driven by Effectiveness ethics committee EudraCT Friedrich Schiller high mortality hyperinflammation IL-6 IMPROVE infections Infectious diseases infliximab International Laboratory molecular molecular diagnostics monoclonal antibody morbidity multicentre Open-label Patient patients with COVID-19 primary endpoint pro-inflammatory cytokine protocol randomised randomised controlled trial receive Registered Research respiratory respiratory infections resulting severe COVID-19 Standard of care systemic inflammatory the disease therapy TNF-α Treatment Trial university Urine [DOI] 10.1186/s13063-022-06566-5 PMC 바로가기 [Article Type] Article
A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic optionsArticle Published on 2022-09-012022-11-16 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] acetyl-CoA Activation alteration analyzed anti-inflammatory function CLYBL combating Control convert COVID-19 COVID-19 patients COVID-19 progression COVID-19 samples Critical Defense enzyme healthy controls Host host protein Human identify immune modulatory Immunity increase in Inflammation itaconate Macrophage metabolism metabolite moderate modulating observation pathway Pneumonia Protein proteome proteomes proteomic regulated RNA virus SARS-CoV-2 viruses severe symptom signaling pathway suggested TCA cycle the disease therapeutic option therapeutic target treating COVID-19 Urine worsening [DOI] 10.1007/s11427-021-2070-y PMC 바로가기