Anti-VEGF agents: As appealing targets in the setting of COVID-19 treatment in critically ill patientsReview article Published on 2021-12-012022-10-05 Journal: International immunopharmacology [Category] 바이오마커, 치료법, [키워드] “cytokine storm” acute respiratory distress addressed Angiogenesis anti-inflammatory effect Anti-VEGF Anti-VEGF therapy ARDS candidate Compound contribute Coronavirus disease-19 COVID-19 Critically ill patient critically ill patients cytokine disease pathogenesis Evidence highlight humanized monoclonal antibody Inflammation inflammatory process inhibitor medication medications protocol receptors SARS-CoV-2 syndrome target the cytokine storm therapeutic therapeutic target therapy Treatment tyrosine VEGF [DOI] 10.1016/j.intimp.2021.108257 [Article Type] Review article
Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection전염증성 CXCL-10, TNF-α, IL-1β 및 IL-6: SARS-CoV-2 감염의 바이오마커Article Published on 2021-12-012022-09-11 Journal: Archives of Virology [Category] 바이오마커, [키워드] antiviral cytokine antiviral cytokines Asymptomatic Biomarker Biomarkers categories category caused chemokine chemokines city clinical manifestation clinical manifestations controls CXCL-10 CXCL10 cytokine cytokine production Cytokines disease early phase except for excessive cytokine production Factor Hospitalized IFN-γ IL-12 IL-17 IL-1β IL-4 IL-6 immune system India individual infected patients Infection infiltration inflammatory cells investigated Level Luminex platform mildly symptomatic patient mildly symptomatic patients morbidity morbidity and mortality no difference Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic of COVID-19 Patient Plasma cytokine Postinfection pro-inflammatory cytokine pro-inflammatory cytokines recovered patient recovered patients reduced SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2-infected patient significantly higher significantly lower symptomatic the patient TNF-α uninfected control VEGF Viral viral infections virus replication [DOI] 10.1007/s00705-021-05247-z PMC 바로가기 [Article Type] Article
DEspR high neutrophils are associated with critical illness in COVID-19Article Published on 2021-11-172022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] Admission association Blood blood sample caused CCL23 Cell chemokine circulating clinical parameter Cohort collected COVID-19 COVID-19 illness Critical cytokine Cytometry death Diseases elevated ELISA evaluated examined expressing Flow hospitalized patient Immune cell immune response immunology Inflammation negative controls NET NETosis neutrophil Neutrophil extracellular trap no symptom outcome patients with COVID-19 Plasma level pro-inflammatory receptor reduce SARS-CoV-2 SARS-COV-2 infection subpopulation subpopulations subsequent subset therapy tissue damage Treatment VEGF was used were measured White blood cell with COVID-19 [DOI] 10.1038/s41598-021-01943-7 PMC 바로가기 [Article Type] Article
Blood Cytokine Analysis Suggests That SARS-CoV-2 Infection Results in a Sustained Tumour Promoting Environment in Cancer PatientsArticle Published on 2021-11-152022-10-31 Journal: Cancers [Category] COVID-19, [키워드] Analysis Anti-inflammatory cancer development cancer patient Cancer patients cancer progression cancers chemokine chemokines chronic circulating conducted control group COVID COVID-19 COVID-19 complication cytokine described dysregulation elevated Environment Factor Factors Follow-up group growth factor haematological cancers haematological malignancies haematological malignancy Health care worker higher risk IFN-β IL-17A IL-6 immune factor immune response immune system Impact Infection Inflammation investigated less longitudinal non-infected outcome Patient patients persistence pro-inflammatory progression Promoting protective effect recent Result SARS-CoV-2 SARS-COV-2 infection shown significantly simple solid cancers T cell Th1 Th17 Th2 TNF-α Treatment TSLP VEGF virus [DOI] 10.3390/cancers13225718 PMC 바로가기 [Article Type] Article
Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot studyResearch Article Published on 2021-10-142022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] accompanied Biochip Case-control correlation Course COVID-19 cytokine cytokine profile Cytokines demonstrated EGF evidenced IFN-y IFN-γ IL-10 IL-1α IL-2 IL-4 IL-6 IL-8 IL8 marker MCP-1 oxidative stress parameter Patient pilot study predict presentation primary care serum severe COVID-19 severe COVID-19 patients significantly higher tested the disease the patient TNF-α VEGF were measured worsened [DOI] 10.12688/f1000research.55166.2 PMC 바로가기 [Article Type] Research Article
COVID-19 Coronavirus-Induced Atypical Pneumonia: Efficacy of the Monoclonal Antibody Bevacizumab in Moderate to Severe CasesInternal Medicine Published on 2021-09-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome angiogenseis anti-VEGF monoclonal antibody Atypical Atypical pneumonia bevacizumab COVID-19 COVID-19 pandemic develop endothelial global pandemic growth factor hypoxia induce moderate Novel coronavirus Patient Pneumonia proliferation severe inflammation severe pneumonia syndrome treated Vascular VEGF [DOI] 10.7759/cureus.18317 PMC 바로가기 [Article Type] Internal Medicine
Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidatesCovid-19에서 바이러스 표적 및 차별적으로 발현 된 유전자의 네트워크 이웃은 약물 표적 후보입니다.Article Published on 2021-09-232022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm artificial intelligence candidate Computational biology and bioinformatics COVID-19 COVID-19 pandemic COVID-19 symptoms Data integration Data mining differentially expressed differentially expressed gene Diseases drug drug target drugs targeting Explainable artificial intelligence FDA-approved drugs human protein human proteins Infection Interaction interactions interactome mechanism mechanisms methodology network Network topology nitric oxide pathway predict protein interactions SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Signaling target the disease VEGF [DOI] 10.1038/s41598-021-98289-x PMC 바로가기 [Article Type] Article
A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditisArticle Published on 2021-09-102022-10-06 Journal: Med (New York, N.Y.) [Category] SARS, 진단, [키워드] acute respiratory syndrome Adults Alpha Analysis applied approach Blood blood cell Cell cellular characterized chemokine chemokines children condition coronavirus correlated COVID-19 cytokine disease elevated endothelial form Gene Expression gene signature growth factor HIF-1α Hospitalized hyperinflammation Hyperinflammatory Infection Inflammatory inhibitors Kawasaki disease lack lack of responses to type I and type II IFN secretion milieu MIS-C molecular myocarditis Necrosis NF-κB nuclear Occurrence oxidative stress pathophysiology PIMS-TS proportion response SARS-CoV-2 SARS-COV-2 infection scRNA-seq Signaling single-cell Single-cell transcriptomics sustained syndrome TNF-α TNF-α and NF-κB signaling type I type II IFN type II interferons unique VEGF were measured [DOI] 10.1016/j.medj.2021.08.002 PMC 바로가기 [Article Type] Article
Identification of Immune Activation Markers in the Early Onset of COVID-19 InfectionCOVID-19 감염의 초기 발병에서 면역 활성화 마커의 식별Cellular and Infection Microbiology Published on 2021-09-032022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 바이오마커, [키워드] age analyzed associated symptoms CoV COVID-19 COVID-19 associated symptoms COVID-19 infection cross-sectional cytokine cytokine profile Cytokines determine disease displaying early diagnosis early stage early stages elevated exploratory healthy control healthy controls HGF identification IL7 immune activation Infection inflammatory markers IP-10 marker mDC MIF MIP-1b Negative PCR Onset outpatient clinic Patient patient group PCR test Peripheral blood plasma sample plasma samples positive SARS-CoV-2 SARS-COV-2 infection screened serum sample serum samples single center Symptom symptoms of COVID-19 target tested Treatment university upregulation VEGF Vienna [DOI] 10.3389/fcimb.2021.651484 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Specific Features of the Coagulopathy Signature in Severe COVID-19 PneumoniaMedicine Published on 2021-08-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory distress syndrome Analysis baseline Biomarker Characteristics clinical Coagulopathy correlation COVID-19 COVID-19 patient COVID-19 patients CXCL10 enrolled feature GM-CSF IL-10 immune dysregulation intensive care mechanical ventilation Multivariable regression analysis Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients outcome P-selectin Pathogenesis Patient plasma plasma biomarker plasma concentration Pneumonia Principal component required rising severe COVID-19 patients severe pneumonia severity signature significantly significantly higher Specific thrombosis thrombotic complication unique VCAM1 VEGF venous [DOI] 10.3389/fmed.2021.675191 PMC 바로가기 [Article Type] Medicine