Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice감수 분열 게이트 키퍼 STRA8은 생쥐의 정자 형성 동안 Nr1d1 발현을 억제하여자가 포식을 억제합니다Research Article Published on 2019-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition autophagy bind Cell cell cycles cells cellular chromosomal cohesion Critical demonstrated DNA double strand double strand break DSBs ectopic expression Effect expression Fertility function Genes Genetic genomic germ cells haploid gamete homolog hormone receptor inhibit male maturation meiosis meiotic mice mitotic molecular Nr1d1 nuclear organelle promoter Protein Recombination required retinoic acid sexual reproduction spermatogenesis STRA8 suppresse suppressor synapsis target gene Target genes Transcription transcriptional transition turn Ulk1 upregulated upregulation Vertebrate vertebrates [DOI] 10.1371/journal.pgen.1008084 PMC 바로가기 [Article Type] Research Article
The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in ArchitectureResearch Article Published on 2012-01-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence architecture Author Bacteria Betacoronavirus binding binding site cell tropism change changed changes in complex consequence coronavirus Coronaviruses domain domains Evolution example Factor glycan glycoprotein Hemagglutinin-esterase Interaction Ligand Lineage living cell Major MHV modifications MOST mouse hepatitis virus murine organ Pathogenesis Protein Protozoa receptor resolved shift sialic acid specificity sugar Topology vertebrates virion virus [DOI] 10.1371/journal.ppat.1002492 PMC 바로가기 [Article Type] Research Article