Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to humanOriginal Research Article Published on 2020-11-052022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] acute respiratory syndrome analyses Analysis analyzed bat coronavirus RaTG13 carried caused conservation conservation analysis Contact coronavirus coronavirus disease coronavirus strains CoV COVID-19 domain GISAID groups Host identify Multiple sequence alignment N-terminal domain NCBI pandemic pangolin coronavirus pangolin CoV Phylogenetic plague public health emergency RaTG13 RBD Receptor-binding domain recombination event recombine Result reveal S2 subunit SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike sequence similarity spike strain Strains Transmission Variation viral adaptation virus was used whole-genome [DOI] 10.1093/emph/eoaa041 PMC 바로가기 [Article Type] Original Research Article
Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1Research Published on 2020-08-312022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] addition Affect Amino acid amino acid residue Analysis Asymptomatic betacoronaviruses C-terminal changes changes in China COVID-19 Deletion Effects experiment expression Gene Expression Genome genome sequence genomic genomic region geographical areas GISAID database global pandemic I-TASSER in viral in vitro indicate innate immune system Interaction interferon-alpha involved MAFFT mechanism MERS-CoV Mutagenesis non-structural protein non-structural proteins nsp1 nucleotide ORF1a ORF1ab overlapping pathogenic Patient pauci-symptomatic polyproteins previous study Protein reduction Regulation Replication reported respiratory responsible Result SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequences SARS-CoV-2 viral strain subjects viral adaptation viral pathogenicity viral replication viral strain was performed Wuhan [DOI] 10.1186/s12967-020-02507-5 PMC 바로가기 [Article Type] Research
Time-series analyses of directional sequence changes in SARS-CoV-2 genomes and an efficient search method for candidates for advantageous mutations for growth in human cellsArticle Published on 2020-08-062022-10-31 Journal: Gene: X [Category] COVID-19, MERS, SARS, [키워드] Analysis candidate changes in conducted COVID-19 directional Ebolavirus Frequency Genome genomes growth human cell human cells in viral Mutation Occurrence oligonucleotide oligonucleotides PCR primer Phylogenetic tree SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Seven Therapeutic oligonucleotide thought viral adaptation Zaire ebolavirus zoonotic virus [DOI] 10.1016/j.gene.2020.100038 PMC 바로가기 [Article Type] Article
Hepatitis E Virus Shows More Genomic Alterations in Cell Culture than In VivoArticle Published on 2019-11-222023-08-29 Journal: Pathogens [Category] E형 간염, [키워드] hepatitis E virus HEV whole genome sequencing spontaneous mutagenesis viral adaptation [DOI] 10.3390/pathogens8040255 PMC 바로가기 [Article Type] Article
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?Review Published on 2019-07-012023-08-29 Journal: Viruses [Category] E형 간염, [키워드] broad-spectrum antivirals glypicans heparan sulfate proteoglycans HSPG intra-host adaptation syndecans tropism viral adaptation viral attachment receptor Viral binding [DOI] 10.3390/v11070596 PMC 바로가기 [Article Type] Review
Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cellsArticle Published on 2016-05-012023-06-23 Journal: Virology [Category] 신종인플루엔자, [키워드] A/Hamburg/04/2009 hemagglutinin High-throughput sequencing reverse genetics viral adaptation [DOI] 10.1016/j.virol.2016.02.002
Genetic evolution of PB1 in the zoonotic transmission of influenza A(H1) virusArticle Published on 2014-10-012023-06-02 Journal: Infection, genetics and evolution : journal of mol [Category] 조류인플루엔자, [키워드] Genetic evolution Influenza A(H1) interspecies transmission Polymerase basic-protein 1 viral adaptation [DOI] 10.1016/j.meegid.2014.07.024
Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential TherapeuticsResearch Article Published on 2013-08-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 5-FU activity antiviral activity antiviral drug Author biochemical Combination compared conserved coronavirus CoV CoV replication CoVs Critical decrease demonstrated determine Epidemic Evidence Exoribonuclease Express Genetic high mutation rate human coronavirus human disease Hypothesis identify increase in inhibitor inhibitory activity lethal MERS-CoV Middle East Mutagenesis Mutation Next-generation sequencing NO nonstructural protein 14 nsp14-ExoN nucleotides Population Potential Prevent Probability Proofreading provide RdRP Replication required respiratory responsible ribavirin RNA RNA synthesis RNA virus SARS-CoV selective sensitivity severe Support susceptible target Therapeutics to define treated Vaccine viral adaptation Viral protein viral RNA synthesis virus virus replication while wild-type zoonotic [DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article
Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groupsResearch Article Published on 2006-10-042022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] acute respiratory syndrome adaptive addition Amino acid changes in characterized contribute coronavirus Course CoV detected different domain Epidemic epidemiological Evolution found greater group groups heptad repeat hosts human host humans membrane fusion occurred outbreak Phylogenetic tree positive Positive selection proportion Protein RBD receptor residue Result reveal S gene S protein SARS-CoV selected selective selective pressure selective sweep spike gene strain subsequent the S protein Transmission two group two groups Variation viral adaptation [DOI] 10.1186/1471-2180-6-88 PMC 바로가기 [Article Type] Research Article
Molecular Epidemiology of SARS-associated Coronavirus, BeijingResearch Published on 2005-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] amplified amplified products Beijing Characteristics clinical sample Cluster collected coronavirus different dominant Epidemics geographic location Guangdong Host immune pressure isolate loci molecular Molecular epidemiology motif Mutation nucleotide Patient patients reported RT-PCR RT-PCR, research SARS-CoV selective sequence Sequencing Severe acute respiratory syndrome single nucleotide variation SNV SNVs to define Variation viral adaptation were used [DOI] 10.3201/eid1109.040773 PMC 바로가기 [Article Type] Research