viral spike – Page 3 – Communicable Diseases Research

Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19

SARS-COV-2 스파이크 당 단백질에 대한 IgG 반응의 양은 COVID-19로부터 폐 회복을 예측한다.

Observational Study

Published on 2022-03-072022-09-01
Journal: Scientific Reports [Category] MERS, 바이오마커, 임상, 진단, 치료기술, 치료법,

Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors

다양한 세포 유형에서 SARS-CoV-2 감염에 대한 비교 연구: 잠재적 수용체의 역할에 대한 생물물리학적 전산적 접근

Article

Published on 2022-03-012022-09-12
Journal: Computers in biology and medicine [Category] MERS, SARS, 진단,

[키워드] A549 ACE2 addition AGTR2 angiotensin-converting enzyme 2 approach CD147 Cell cell line cell lines Cell susceptibility cellular Comparative conditions dependent on docking early infection expected experiment expression expression level expression levels greater Heat shock HEK293 HepG2 Host host protein HSPA5 Infection Interaction kinetic less Lungs macromolecular Macromolecular crowding membrane NRP1 NTERA-2 parameter predict predicted promote protease Protein Quantitative receptor receptors Research respiratory tract SARS CoV-2 SARS-COV-2 infection serine 2 stimulate susceptibility TMPRSS2 transcriptomic data transmembrane viral dynamics viral growth viral spike Viral spike. virus
[DOI] 10.1016/j.compbiomed.2022.105245 PMC 바로가기 [Article Type] Article

High-throughput virtual screening of drug databanks for potential inhibitors of SARS-CoV-2 spike glycoprotein

SARS-COV-2 스파이크 당 단백질의 잠재적 억제제에 대한 약물 데이터 뱅크의 고 처리량 가상 스크리닝

Article

Published on 2022-03-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제,

[키워드] ACE2 ADME approved best binding binding energy C terminal caused chidamide complexes Compound COVID-19 docking domain ebastine effort FDA approved drug flexible in silico Approach indacaterol individual inhibitors of SARS-CoV-2 interact Interaction interactions investigated Ligand MD simulation MD simulations molecular molecular dynamics Novel coronavirus performed potential inhibitors protein-ligand protein-ligand interaction recorded regorafenib SARS-CoV-2 silodosin SMD spike glycoprotein Spread stability Steered molecular dynamics subunit target tasosartan the RBD treat Viral viral RBD viral S viral S protein viral spike Virtual screening virus
[DOI] 10.1080/07391102.2020.1835721 PMC 바로가기 [Article Type] Article

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

SARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다

Research Article

Published on 2022-02-082022-09-10
Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while
[DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article

A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 replicon

Coronaviruses

Published on 2022-02-042022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS,

Global conserved RBD fraction of SARS-CoV-2 S-protein with T500S mutation in silico significantly blocks ACE2 and rejects viral spike

Research

Published on 2022-02-042022-10-29
Journal: Translational Medicine Communications [Category] COVID-19,

Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection risk

SARS-CoV-2 스파이크 돌연변이의 분자 역학 시뮬레이션 분석 및 감염 위험에 대한 애완 동물 및 야생 동물의 ACE2 평가

Article

Published on 2022-02-012022-09-11
Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 receptor ACE2 receptor recognition Analysis animal Animal host binding binding ability binding affinity caused contagious coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical glycoprotein health emergency Host human ACE2 humans infection risk interact Interaction intermediate host life Missense mutation Missense mutations modeling mole molecular dynamics molecular dynamics simulations Molecular modeling Mus mutant Mutation mutations PALM Pandemics pangolin question RBD RBD region Receptor-binding domain reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 transmission spike gene spike glycoprotein Spike mutant Spike protein Stress susceptibility the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 the spike protein transmission of SARS-CoV-2 transmitted viral spike virus vole wild animal wild animals
[DOI] 10.1016/j.compbiolchem.2021.107613 PMC 바로가기 [Article Type] Article

Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 Individuals

Article

Published on 2022-01-292022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] Activation analyzed antibodies antibody production Antibody Response avidity B cell B cells breadth circulating antibodies conserved coronavirus Coronaviruses COVID-19 cross-reactive Endemic expansion feature Formation generate IgG IgG antibody IgG response individual Infection investigated MBC memory memory B cell Mild naïve nucleocapsid plasmablasts Population Protein Proteins reactive reactivity Receptor binding domain Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein Severe infection subject the antibody response the N protein the S protein viral spike α-coronavirus β-coronavirus β-Coronaviruses
[DOI] 10.3390/pathogens11020186 PMC 바로가기 [Article Type] Article

mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant

mRNA 부스터 면역화는 SARS-CoV-2 오미크론 변이체에 대한 강력한 중화 혈청 활성을 유도합니다

Brief Communication

Published on 2022-01-192022-09-10
Journal: Nature Medicine [Category] MERS, SARS, 변종, 진단,

[키워드] antibodies BNT162b2 booster Booster vaccine both groups Clinical use Cohort convalescent individual convalescent individuals COVID-19 vaccine dose elicit epitope Epitopes globe glycoprotein humoral immune response immune evasion immunization IMPROVE in both group individual Infection lack monoclonal antibodies monoclonal antibody mRNA Mutation neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity omicron Omicron variant polyclonal sera Pseudovirus neutralization assays rapid increase recipient recipients SARS-CoV-2 sera serum serum neutralizing capacity significant increase spike glycoprotein the SARS-CoV-2 Vaccines variant variant of SARS-CoV-2 Viral viral spike
[DOI] 10.1038/s41591-021-01676-0 PMC 바로가기 [Article Type] Brief Communication

Oral cavity infection by the SARS-CoV-2: emphasizing the essence of masking and peptide therapeutics

Correspondence

Published on 2022-01-102022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,