Virus-Like Particles Are Efficient Tools for Boosting mRNA-Induced Antibodies바이러스 유사 입자는 mRNA 유도 항체를 강화하기 위한 효율적인 도구입니다Article Published on 2022-06-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies Antibody Response Antibody responses approved boost COVID-19 economics Efficacy efficient Heterologous heterologous prime-boost heterologous prime-boost vaccination strategies homologous investigated maintain mRNA mRNA-1273 mRNA-1273 vaccine overcome Particle priming reduced regimen SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant the antibody response Vaccination strategy Vaccine vaccine candidate Virus-like particle virus-like particles VLP VLPs VOCs were used [DOI] 10.3389/fimmu.2022.864718 PMC 바로가기 [Article Type] Article
Investigation of Avian Influenza H5N6 Virus-like Particles as a Broad-Spectrum Vaccine Candidate against H5Nx VirusesArticle Published on 2022-04-282023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] Avian influenza virus H5N6 Vaccine virus-like particles [DOI] 10.3390/v14050925 PMC 바로가기
Impact of SARS-CoV-2 Variants on the Analytical Sensitivity of rRT-PCR AssaysrRT-PCR 분석의 분석 감도에 대한 SARS-CoV-2 변이체의 영향Article Published on 2022-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha analytical sensitivity assays Beta Chinese coronavirus country Critical Delta delta variant diagnostic E gene Efficacy Efficiency evaluate Evolution Gamma had no highlight Immune escape Impact Liferiver management MS2 Mutation N gene no significant effect omicron optimization ORF1ab gene pandemic pathogenicity PCR amplification Prevention and control regions reverse transcriptase reverse transcriptase PCR rRT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus significant effect strategic management Transmissibility variant viral mutation Viral mutations virus Virus-like particle virus-like particles were used [DOI] 10.1128/jcm.02374-21 PMC 바로가기 [Article Type] Article
A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques캡시드 바이러스 유사 입자 기반 SARS-CoV-2 백신은 높은 수준의 항체를 유도하고 붉은털 원숭이를 보호합니다Article Published on 2022-04-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody titers binding binding and neutralizing antibodies broad neutralizing antibodies capsid caused clinical testing comparable control group convalescent Corona coronavirus COVID-19 demonstrated disease dose-dependent manner Efficacy Evidence evidence of immunogenicity increase in Level macaque mice Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers no evidence of non-human primate non-human primates non-human primates (NHP) protection Protective reduction in respiratory rhesus macaques SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single vaccination Vaccine vaccine administration vaccine group variants variants of concern variants of concern (VOCs) Viral Viral load Virus-like particle virus-like particles virus-like particles (VLP). VLP VOCs worldwide pandemic [DOI] 10.3389/fimmu.2022.857440 PMC 바로가기 [Article Type] Article
Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response재조합 VLP는 천연 SARS-COV-2 단백질에서 면역원성을 나타내지 않는 RBM 펩타이드를 강화하여 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-04-012022-09-11 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Antigen antigenicity Antisera candidate carrier protein core antigen coronavirus demonstrated effective delivery elicit epitope Epitopes HBcAg immunization in vitro inactivated indicate KLH linear mice motif Multi-epitope vaccine Neutralizing activity neutralizing antibody Neutralizing antibody response New overlapping Particle peptide peptide epitope peptides Protein RBM reactivity receptor binding motif receptor-binding motif Receptor-binding motif (RBM) recombinant respiratory robust S1 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine variants virus virus infection virus mutation Virus-like particle virus-like particles Virus-like particles (VLPs) VLP VLPs [DOI] 10.1016/j.nano.2022.102527 PMC 바로가기 [Article Type] Article
The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus ParticlesSARS-CoV-2 스파이크 단백질의 "LLQY" 모티프는 S가 바이러스 입자에 통합되는 데 영향을 줍니다.Article Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alter Amino acid amino acid residue amino acids antiviral drug antiviral drugs assembly biological significance Biosynthesis caused Cell culture cleavage cleavage site cleavage sites cleaved conformational conservation conserved Contact contribute coronavirus COVID-19 epidemic Critical demonstrated Effectiveness expressed glycoprotein hydrogen Hydrogen bond hydrogen bonds incorporation Infection intrachain junction key amino acid key amino acids less Lineage LLQY domain membrane fusion motif mutated Mutation Neutralizing antibodies Particle Prevent processing producer cell protease Protein protein synthesis protein synthesis and cleavage Pseudotyped virus pseudovirus pseudoviruses reduce residue S protein S1/S2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability subcellular localization synthesis the S protein the SARS-CoV-2 Transmission tyrosine Vaccines viral entry viral infection virus virus assembly Virus-like particle virus-like particles [DOI] 10.1128/jvi.01897-21 PMC 바로가기 [Article Type] Article
Classical and Next-Generation Vaccine Platforms to SARS-CoV-2: Biotechnological Strategies and Genomic VariantsSARS-CoV-2에 대한 고전 및 차세대 백신 플랫폼: 생명공학 전략 및 게놈 변이Review Published on 2022-02-182022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] aAPC Ad5-nCoV adaptive Amino acid amino acids animals antibody applied B.1.1.7 B1.351 BBIBP-CorV bind Biotechnology BNT Cell classical clinical trial consequence CoronaVac coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs D614G Deletion demonstrated dendritic cell dendritic cells domain escape Evolution genomic variant genomic variants HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 high affinity HKU1 hosts Human humans inactivated incorporation inhibit INO-4800 JNJ-78436735 lentiviral Lentiviral vector LV-SMENP-DC MERS-CoV molecular mRNA mRNA-1273 mutated nCoV New new SARS-CoV-2 new strain NL63 NVX-CoV2373 vaccine P.1 pathogen Pathogens platform Protein RBD receptor ACE2 Receptor-binding domain recombinant vaccine recombinant vaccines replacement residue responsible RNA vaccines S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants strain Strains Strategy subunits technological platforms tested the S protein Transmissibility trials Vaccine vaccine production Vaccines variant variants variety Viral virus-like particles β-coronavirus β-CoV β-CoVs [DOI] 10.3390/ijerph19042392 PMC 바로가기 [Article Type] Review
Multiple Neuraminidase Containing Influenza Virus-like Particle Vaccines Protect Mice from Avian and Human Influenza Virus InfectionArticle Published on 2022-02-182023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Avian influenza virus Heterosubtypic immunity neuraminidase virus-like particles [DOI] 10.3390/v14020429 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Virus-Like Particle Neutralizing Capacity in Blood Donors Depends on Serological Profile and Donor-Declared SARS-CoV-2 Vaccination History혈액 기증자의 SARS-CoV-2 바이러스 유사 입자 중화 능력은 혈청학적 프로필과 기증자가 선언한 SARS-CoV-2 예방 접종 이력에 따라 다릅니다.Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analyzed anti-RBD anti-receptor-binding domain anti-S Anti-spike antibody approach B.1.1.7 B.1.351 B.1.617.2 Beta Blood blood donor Blood donors breadth Canadian Capacity characterized coronavirus cross-sectional cross-sectional design Delta Donor elevated Evidence evidence of Gamma groups history humoral indicate initial initial stages less neutralization neutralization assays neutralization capacity Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers nucleocapsid Particle plasma presence or absence profile Protein Pseudotyped virus random Receptor-binding domain reduced repeated respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant second dose second dose of vaccine service severe acute respiratory syndrome Coronavirus signal significantly specimen spike Stage stratified subset unlikely vaccination Vaccine variant variants of concern virus-like particles VLP VLPs VoC VOCs was used wild type wild-type [DOI] 10.1128/spectrum.02262-21 PMC 바로가기 [Article Type] Research Article
The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion ReleaseResearch Article Published on 2022-02-012022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] acute respiratory syndrome autophagy cellular membranes complex coronavirus dependent on E3 ligase ENhance enzyme Golgi apparatus Interaction Ligase maturation membrane protein Modification molecular mechanism performed regulate Release residue RNA interference RNF5 SARS-CoV-2 ubiquitin ubiquitination viral envelope protein viral particle virion virus virus-like particles [DOI] 10.1128/mbio.03168-21 PMC 바로가기 [Article Type] Research Article