virus spike protein – Page 3 – Communicable Diseases Research

SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses

Article

Published on 2021-08-302022-10-31
Journal: International journal for equity in health [Category] COVID-19,

A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus

감염에 대한 SARS-CoV-2 RBD 돌연변이와 ACE2 수용체 유전 변이의 결합된 효과를 평가하기 위한 전산 접근 방식: COVID-19 숙주-병원체 넥서스

Cellular and Infection Microbiology

Published on 2021-08-092022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종,

[키워드] ACE ACE2 ACE2 receptor ACE2 variant angiotensin converting enzyme 2 receptor approach association binding circulating Combined complex Contact COVID-19 destabilize determined by Effect evaluate free energy GISAID hydrophobic hydrophobic interaction hydrophobic interactions implication individuals infection rate mitigate molecular molecular interaction Mutation mutations nexus offer pattern PDB platform polar polymorphism Population Protein Protein binding RBD Receptor binding domain reported Repository residues retrieved SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 RBD spike Spike protein stability the disease variant Variation variations virus virus spike protein Virus-host interaction ΔΔG
[DOI] 10.3389/fcimb.2021.707194 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies

Research article

Published on 2021-08-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 신약개발,

[키워드] affected Analysis antiviral drugs binding energy conducted Corona COVID-19 COVID-19 disease deviation docking Doxorubicin drug drugs drugs targeting evaluate Exemestane fluctuation Gatifloxacin gyration host cell Hydrogen bond in silico inhibit Interaction Interpretation MDs molecular interaction Molecular simulation pandemic pathogenic Prevent radius RBD complex reference Research respiratory Respiratory illness RMSD RMSF root SARS-CoV-2 SARS-CoV-2 spike protein Simulation study Spike protein Spread square suggested the SARS-CoV-2 therapeutic molecules transmitted virus spike protein Wuhan, China
[DOI] 10.1016/j.sjbs.2021.04.057 [Article Type] Research article

Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma

비호지킨 림프종을 가진 면역저하 환자에서 SARS-CoV-2의 장기적 진화

Research Article

Published on 2021-07-282022-09-10
Journal: mSphere [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] A222V accelerated accumulated accumulation adaptive Administered alterations Amino acid amino acid change Antigen Community Convalescent plasma therapy convergent evolution COVID-19 Deletion epidemiological evaluate Evolution Evolution of SARS-CoV-2 Genome Genome sequencing identify immune evasion Immune status Immunocompromised Immunocompromised host immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunosuppressive immunosuppressive therapy infected individuals Infection long-term infection mitigate MONITOR Mutation mutations Non-Hodgkin Lymphoma occurred pandemic virus pathway Patient polymorphism Protein recent reported risk SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 infections scenario shown single-nucleotide Single-nucleotide polymorphisms SNPs spike Spike protein Support survival the SARS-CoV-2 therapy Transmission Trigger variant variants variants of concern Viral Viral genome sequencing virus virus spike protein was performed
[DOI] 10.1128/mSphere.00244-21 PMC 바로가기 [Article Type] Research Article

The prevalence of SARS-CoV-2 antibodies in triage-negative patients and staff of a fertility setting from lockdown release throughout 2020

Original Article

Published on 2021-07-272022-10-31
Journal: Human Reproduction Open [Category] COVID-19,

[키워드] acute respiratory syndrome age analyzed antibodies antibody ART ART patient assisted reproduction Asymptomatic blood sample Care carried chemiluminescence CLIA Cohort collected data Consensus coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain Evidence exhibiting fertility unit form Generalizability groups HCW HCWs Health care worker highest IgG IgG seroprevalence IgM IgM and IgG immunized immunoassay immunoassays increase in Infection lack limit lockdown measure Measures men molecular test nasopharyngeal swabs no significant difference Older age pandemic Patient PCR testing positive positive molecular test positive result positive serology Prevalence prevalence rate Protective reproductive Research resource risk S1 and S2 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 prevalence trends serological serological test Serological testing severe acute respiratory syndrome coronavirus 2 significantly higher Spike protein study period the SARS-CoV-2 translation Trial vaccination virus virus spike protein was recorded were assessed women
[DOI] 10.1093/hropen/hoab028 PMC 바로가기 [Article Type] Original Article

Structural and Dynamical Differences in the Spike Protein RBD in the SARS-CoV-2 Variants B.1.1.7 and B.1.351

SARS-CoV-2 변이체 B.1.1.7 및 B.1.351에서 스파이크 단백질 RBD의 구조 및 동적 차이

Article

Published on 2021-07-082022-09-11
Journal: The journal of physical chemistry. B [Category] SARS, 변종,

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans

인간의 SARS-CoV-2 감염에 대한 중화 항체 반응의 동역학 및 상관 관계

Article

Published on 2021-06-092022-09-11
Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, 치료기술,

[키워드] age antibody antibody kinetics Antibody Response broad spectrum correlates of neutralization COVID-19 COVID-19 pandemic Critical cross-neutralizing demonstrated disease severity evaluated exceptional exhibiting Gender half-live half-lives Human IgG IgG antibody individual individuals Infection initial key factor Kinetics longitudinal cohort Mild multivariate neutralization Neutralizing Neutralizing activity Neutralizing antibodies Neutralizing antibody response purified reactivity SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2-neutralizing antibody serum Spike protein statistical sustained symptomatic infection understanding Vaccination strategies virus spike protein
[DOI] 10.1016/j.chom.2021.04.015 PMC 바로가기 [Article Type] Article

ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin

Article

Published on 2021-06-072022-10-31
Journal: Cells [Category] COVID-19, SARS,

Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries

약물 라이브러리의 체외 스크리닝에 의한 SARS-CoV-2 수용체 결합 억제제의 식별

Article

Published on 2021-05-272022-09-10
Journal: Molecules [Category] SARS, 신약개발, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Analysis angiotensin angiotensin-converting enzyme 2 (ACE2), high-throughput screening approach binding binding site Cell compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy described docking drug drug library Drug repurposing effective Efficacy ellagic acid enzyme global pandemic heparin sodium human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 IC50 identification identify in vitro inhibitor inhibitors Interaction library molecular docking analysis RBD RBD-ACE2 Receptor binding domain receptor binding domain (RBD) reduction respiratory responsible Safe SARS-CoV-2 SARS-CoV-2 RBD Screening severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule inhibitors (SMIs) sodium Spike protein the RBD the SARS-CoV-2 therapy these compound these compounds Vero E6 Vero E6 cell VERO E6 cells Viral viral infection virus virus spike protein
[DOI] 10.3390/molecules26113213 PMC 바로가기 [Article Type] Article

Potential Mechanisms of Cardiac Injury and Common Pathways of Inflammation in Patients With COVID-19

COVID-19 환자의 심장 손상 및 일반적인 염증 경로의 잠재적 기전

Review

Published on 2021-03-012022-09-11
Journal: Critical pathways in cardiology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute infectious disease Acute myocarditis acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Apoptosis association autopsy studies binding affinity biologic Biomarker Biomarkers C-reactive protein cardiac cardiac injury cardiovascular complication cardiovascular complications Clinical studies clinical study common controlled clinical studies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine secretion demonstrated despair disease pathogenesis effort Epidemic Genetic genetic recombination High-sensitivity C-reactive protein higher risk histopathological hypoxia in-hospital mortality Inflammation Injury lack lethal disease linear correlation management mechanism morbidity and mortality Myocardial myocarditis other coronaviruses outbreak Outbreaks pandemic Pathogenesis Patient patients hospitalized plasma poor prognosis positive linear correlation Potential potential mechanism Protein Randomized Receptor binding Recombination remains uncertain reported Research risk factor Risk factors significantly spike Spike protein Strong systemic inflammation the disease therapeutic tissue damage Treatment troponin T virus virus spike protein with COVID-19
[DOI] 10.1097/HPC.0000000000000227 PMC 바로가기 [Article Type] Review