Cellular immune response – Page 30 – Communicable Diseases Research

High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

Clinical Medicine

Published on 2020-10-152022-10-30
Journal: JCI Insight [Category] COVID-19, MERS, SARS,

Vaccine strategies for the Mtb /HIV copandemic

Review Article

Published on 2020-10-132022-10-04
Journal: NPJ Vaccines [Category] 비임상,

Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients

Research Article

Published on 2020-10-072022-10-30
Journal: mSphere [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Alpha antibody Asymptomatic Asymptomatic COVID-19 Asymptomatic disease asymptomatic individual asymptomatic patient asymptomatic patients B cell B cells Biochemistry Blood Cellular immune response clinical Clinical characteristics clinical symptom collected complete blood count coronavirus coronavirus disease COVID-19 COVID-19 patients Diagnosis disease elevated epidemicity evaluated examined Face mask faster flow cytometry greater IFN-γ IgG and IgM IL-10 IL-2 IL-4 IL-6 immune response indicated infection control interferon interleukin 2 liver Liver damage liver enzyme Liver function Lymphocytes Necrosis NK cell NK cells outbreak outcome pandemic Patient performed Person phenotype Prevent proceed Protein public health Public health intervention Public health interventions qRT-PCR Quantitative resulting reverse transcription-PCR risk risk factor SARS-CoV-2 serum significantly significantly lower social distancing Spread symptomatic Symptomatic patients T cell T cells throat swab TNF-α Transmission Treatment viral clearance Viral load viral shedding viral titer virus virus transmission were measured while Wuhan, China
[DOI] 10.1128/mSphere.00922-20 PMC 바로가기 [Article Type] Research Article

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Research Article

Published on 2020-10-072022-10-29
Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome adaptive immune responses Adults age Anti-spike Antibody titer Antibody-dependent cellular phagocytosis antiviral immune response caused CD25 CD4 Cellular immune response children circulating clinical manifestation clinical outcomes Concentration concentrations coronavirus coronavirus disease correlated COVID-19 cytokine described difference disease evidenced Factor Frequency generate hospital Hospitalization Hospitalized human coronaviruses humoral identify IFN-γ IL-17A IL-6 immune response increased expression Inflammatory interferon-γ interleukin-17A lower mortality mechanical ventilation mechanisms modulate Mortality mounted Necrosis Neutralizing antibody titer New York City no difference outcome Patient patients with COVID-19 pediatric Pediatric patient people with COVID-19 Pierce Protein response robust SARS-CoV-2 SARS-COV-2 infection serum Serum neutralizing antibody syndrome T cell T cell response T cells TNF-α viral spike protein with COVID-19 younger patients
[DOI] 10.1126/scitranslmed.abd5487 PMC 바로가기 [Article Type] Research Article

Maternal Immunological Adaptation During Normal Pregnancy

Review

Published on 2020-10-072023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] Cellular immune response fetal gestation humoral immune response immune system Immunity
[DOI] 10.3389/fimmu.2020.575197 PMC 바로가기 [Article Type] Review

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

Prefusion-stabilized SARS-CoV-2 Spike 면역원을 인코딩하는 Ad26 벡터 기반 COVID-19 백신은 강력한 체액 및 세포 면역 반응을 유도합니다

Article

Published on 2020-09-282022-09-10
Journal: NPJ Vaccines [Category] 변종, 비임상, 임상,

[키워드] Ad26 Ad26.COV2.S best binding breath Cellular immune response cellular immunity cleavage clinical trial coronavirus coronavirus S coronavirus S protein COVID-19 COVID-19 vaccine Critical demonstrated development effective element elicited etiologic agent evaluated folded protein furin furin cleavage site Heterologous hinge region humoral Humoral immunity IFN-γ induce Intervention membrane-bound mice Mutation Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody observation peptide peptides Phase I prefusion conformation proline prolines prophylactic measure prophylactic measures Protein S protein S protein-based vaccine SARS-CoV-2 SARS-CoV-2 vaccine shown signal peptide signal peptides spike Substitution substitutions Th1 the S protein translated Vaccine Vaccines Viral viral infection viral replication viral surface wild-type
[DOI] 10.1038/s41541-020-00243-x PMC 바로가기 [Article Type] Article

Cross-Protection against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and Protein

Vaccines and Antiviral Agents

Published on 2020-09-232022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] addition amino acids binding cause cell-mediated immune response Cellular immune response cellular receptor Combination Coronavirus vaccines Coronaviruses cross-neutralization cross-protection cross-protective demonstrated develop DNA DNA plasmid DNA viruses effective examined expected Heterologous high mortality human DPP4 humoral immunization immunized immunized mice induce interferon MERS-CoV mice Middle East mouse Mutation Neutralizing antibodies neutralizing antibody platform priming promote Protein provided RBD Recombinant protein regimen respiratory syndrome coronavirus RNA virus S-protein S-pseudovirion sequence sera severe respiratory illness spike spike glycoprotein strain subunit suggested the receptor-binding domain vaccination Vaccine Vaccine development Vaccines variant viral infection viral strain viruses wild-type
[DOI] 10.1128/JVI.01176-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling

Article

Published on 2020-09-112023-06-12
Journal: The Journal of Biological Chemistry [Category] B형 간염,

[키워드] Cellular immune response Hep B) Hep C) hepatitis B virus (HBV hepatitis C virus (HCV immune evasion Innate immunity m6A modification RIG-I sensing viral immunology
[DOI] 10.1074/jbc.RA120.014260 PMC 바로가기

Immune Response to COVID-19: Can We Benefit from the SARS-CoV and MERS-CoV Pandemic Experience?

Review

Published on 2020-09-092022-10-28
Journal: Pathogens [Category] COVID-19,

Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis

Review article

Published on 2020-09-012022-10-05
Journal: Journal of infection and public health [Category] SARS, 유전자 메커니즘,

[키워드] addition adenine Affect Ageing alteration antigen-presenting cell biological function Cellular immune response change chromosome circulating pro-inflammatory cytokine Complication COVID 19 COVID-19 COVID-19 patient Cytokine storm death dinucleotide Effects elderly Factor Gas exchange Hospitalization Hypothesis immune Immune cell immune function immune system immunomodulator impairment increase in Increasing influence inhibitory effect lung lymphocyte morbidity and mortality NAD+ positive Prevent pro-inflammatory cytokine Respiratory function risk sensitivity Severe infection stability susceptibility telomere telomeres
[DOI] 10.1016/j.jiph.2020.06.004 [Article Type] Review article