Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variantB.1.351 SARS-CoV-2 변이체의 감염 및 백신 유도 항체 결합 및 중화Article Published on 2021-04-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] additional spike mutation additional Spike mutations Antibody binding Antibody titer Antibody titers B.1 B.1.351 B.1.351 variant binding antibody convalescent COVID-19 patient D614G deletions domain Efficacy emerging variants exhibited humoral Humoral immunity individual individuals Infection Live virus Moderna Mutation neutralization neutralize Neutralizing antibody titer neutralizing antibody titers polyclonal antibodies polyclonal antibody protective humoral immunity raising Receptor-binding domain reduced reduction in retained SARS-CoV-2 SARS-CoV-2 B.1.351 variant SARS-CoV-2 variant SARS-CoV-2 variants sera spike mutation Spike protein the spike protein vaccinated individual Vaccine vaccine-induced antibodies variant Viral viral neutralization [DOI] 10.1016/j.chom.2021.03.009 PMC 바로가기 [Article Type] Article
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global PerspectiveArticle Published on 2021-04-112022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome Amino acid amino acid substitution analyzed antiviral drug caused clade clades coding region coronavirus coronavirus disease country COVID-19 D614G different time points Diversity dominant variant Evolution of SARS-CoV-2 genetic diversity Genetic variant genomic sequence global pandemic highest highlighting large-scale analysis nucleocapsid ORF10 ORF3a ORF8 P323L Period polymorphic site prevalent Protein provide RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 variant SARS-CoV-2 variants spike glycoprotein Spread Substitution Surveillance the SARS-CoV-2 genome Vaccines variant whole-genome sequences [DOI] 10.3390/biomedicines9040412 PMC 바로가기 [Article Type] Article
The Genetic Variant of SARS-CoV-2: would It Matter for Controlling the Devastating Pandemic?SARS-CoV-2의 유전적 변종: 치명적인 전염병을 통제하는 것이 중요할까요?Review Published on 2021-04-102022-09-10 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 변종, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody neutralization caused Cluster controlling coronavirus COVID-19 D614G Efficacy effort elicited evade Evidence FIVE Genetic variant genetic variants herd immunity highlight immune response immune responses Infection matter Mutation N-terminal domain notable P.1 pandemic of COVID-19 Pathogenesis raised respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein vaccination Vaccine vaccine efficacy Vaccines variant virus virus transmission VOC 202012/01 widespread [DOI] 10.7150/ijbs.59137 PMC 바로가기 [Article Type] Review
Assembly and Entry of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2): Evaluation Using Virus-Like Particles중증급성호흡기증후군 코로나바이러스 2(SARS-CoV2)의 조립 및 진입: 바이러스 유사 입자를 이용한 평가Article Published on 2021-04-092022-09-11 Journal: Cells [Category] MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus assembly Betacoronavirus BSL-3 can be used cell culture conditions chimeric complementary Complementation coronavirus coronavirus 2 COVID-19 Critical CTD cytoplasmic D614G dependent on domain effective envelope evaluate expressing Factors feature Features functional HiBiT homologous host cell inoculated investigated LgBiT matrix MERS-CoV MHV N protein N proteins NanoBiT technology nLuc nucleocapsid offer Particle peptide produced Proteins Release respiratory SARS-CoV2 secretion supported susceptibility target cell target cells Viral viral membrane virus virus assembly Virus-like particle virus-like particles VLP VLPs was used [DOI] 10.3390/cells10040853 PMC 바로가기 [Article Type] Article
Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational studyObservational Study Published on 2021-04-082023-06-15 Journal: EBioMedicine [Category] MERS, SARS, [키워드] clade COVID-19 D614G SARS-CoV-2 severity Transmission [DOI] 10.1016/j.ebiom.2021.103319 PMC 바로가기 [Article Type] Observational Study
The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 PseudovirusSARS-CoV-2 계통 B.1.351 슈도바이러스의 감염성 및 중화 효율에 미치는 영향Communication Published on 2021-04-072022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] affected antibody B.1.351 Casirivimab D614G E484K E484K mutation E484K mutations Efficacy Efficiency Imdevimab Impact indicated Infectivity investigated K417N K417N and E484K mutation of spike Lineage monoclonal antibodies multiple mutation multiple mutations mutant Mutation N501Y N501Y mutation neutralization neutralized Neutralizing antibodies pseudovirus pseudoviruses raising RBD Receptor-binding domain referred to SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant significantly increased South Africa Strains tested the receptor-binding domain Transmissibility variant of SARS-CoV-2 Viral viral infectivity viral spread Wuhan Wuhan strain [DOI] 10.3390/v13040633 PMC 바로가기 [Article Type] Communication
Analysis of SARS-CoV-2 mutations in Mexico, Belize, and isolated regions of Guatemala and its implication in the diagnosis멕시코, 벨리즈 및 과테말라의 고립 지역에서 SARS-CoV-2 돌연변이 분석 및 진단에 미치는 영향Article Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected aligned Amino acid amino acid substitution Analysis analyzed Belize CDC circulating Clustal Omega Complete coronavirus D614G Diagnosis diagnosis of COVID-19 diagnosis of SARS-CoV-2 ExPASY for inclusion Genetic Genetic variation genomic sequence GISAID database greater host genome identify increase in Missense Mutation mutations NC_045512.2 Open reading frame open reading frames ORF8 polyprotein positive primer Primers Region reported SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 mutation sequence sequences Seven severe acute respiratory syndrome Coronavirus South specificity Spike protein Spread spread to Substitution substitutions synonymous translated UCSF Chimera United State United States variant virulence virulent virus Wuhan Wuhan, China [DOI] 10.1002/jmv.26591 PMC 바로가기 [Article Type] Article
Genomic surveillance of SARS-CoV-2 in the Republic of Congo콩고공화국에서 SARS-CoV-2의 게놈 감시Article Published on 2021-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African assigned carried clade Clusters collected contributing to coronavirus Ct values D614G database Genome genomes Genomic surveillance Illumina individual information Lineage Lineage B1 Mutation Next-generation sequencing NGS pangolin provide Republic of Congo RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage SARS-CoV-2 sequence SARS-CoV-2 variants screened sequenced severe acute respiratory syndrome Coronavirus shown spike mutation submitted Surveillance Transmission virus WGS Whole genome sequencing whole-genome sequencing [DOI] 10.1016/j.ijid.2021.03.036 PMC 바로가기 [Article Type] Article
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies Research Published on 2021-03-262022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody B.1.1.7 B.1.351 B.1.351 variant B1.351 circulating collected convalescent convalescent individual convalescent sera coronavirus D614G examined gene encoding GFP immune evasion immunized individual individuals infected individuals Infection less Mutation nasal swab natural infection Neutralization assay neutralized neutralizing antibody neutralizing titers Pfizer positive raise reduction in remained reporter cell risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 B.1.1.7 SARS-CoV-2 variant sensitivity sera Serological assay South Africa Spike protein spread to strain Symptoms tested the spike protein United Kingdom vaccinated individual vaccination vaccine dose vaccinees variant virus [DOI] 10.1038/s41591-021-01318-5 [Article Type] Research
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralizationBNT162b2 백신 유발 중화에 대한 SARS-CoV-2 D614G 돌연변이의 효과Brief Communication Published on 2021-03-252022-09-10 Journal: NPJ Vaccines [Category] 변종, 비임상, [키워드] accumulated mutations BNT162b2 BNT162b2 vaccine breath candidate circulating clinical trial COVID-19 vaccine D614G D614G mutation dominant Efficacy human sera Immunity Mutation neutralization question raising reduced rhesus RNA vaccines SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 neutralization sequence Vaccine virus [DOI] 10.1038/s41541-021-00313-8 PMC 바로가기 [Article Type] Brief Communication