Drug repurposing for COVID-19: Approaches, challenges and promising candidatesReview Published on 2021-06-232023-06-15 Journal: Pharmacology & therapeutics [Category] MERS, [키워드] antivirals clinical trials COVID-19 Drug repurposing emerging viruses [DOI] 10.1016/j.pharmthera.2021.107930 PMC 바로가기 [Article Type] Review
Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead OptimizationCovid-19 치료를위한 일부 NSAID의 잠재력에 대한 계산 통찰력 : 우선 순위 세트 및 리드 최적화Article Published on 2021-06-212022-08-31 Journal: Molecules [Category] MERS, SARS, 신약개발, 치료제, [키워드] addition antagonist anti-inflammatory activity anti-inflammatory effect auranofin candidate carried caused Compound compounds conducted COVID-19 cytokine DFT calculations docking drug Drug repurposing effective evaluated expected FDA-approved drug FDA-approved drugs functional Health help indomethacin Inflammation Inflammatory cytokine Inflammatory cytokine storm inhibiting inhibitor inhibitors insight lead lung damage M pro molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations NSAID NSAIDS optimization pandemic parameter Potential priority protease provide provoking responsible resulting Safe SAR SARS-CoV-2 SARS-CoV-2 main protease screened severity sulfinpyrazone target receptor tested therapeutic treating Treatment treatment for COVID-19 [DOI] 10.3390/molecules26123772 PMC 바로가기 [Article Type] Article
Coronaviruses, cholesterol and statins: Involvement and application for Covid-19Review Published on 2021-06-182023-06-15 Journal: Biochimie [Category] MERS, SARS, [키워드] cholesterol coronavirus COVID-19 Drug repurposing Membrane microdomains statins [DOI] 10.1016/j.biochi.2021.06.005 PMC 바로가기 [Article Type] Review
Old drugs for a new indication: a review of chloroquine and analogue in COVID-19 treatmentReview Article Published on 2021-06-142022-10-28 Journal: Porto Biomedical Journal [Category] COVID-19, [키워드] accompanied approved biochemical Chloroquine clinical setting clinical trials COVID-19 COVID-19 pandemic disease drug Drug repurposing Effect Efficacy HCQ highlight Hydroxychloroquine in vitro in vivo indications life-threatening Perspective pharmacological profile randomized clinical trial the disease therapeutic option therapeutic strategy Treatment urgency [DOI] 10.1097/j.pbj.0000000000000132 PMC 바로가기 [Article Type] Review Article
An update on emerging therapeutics to combat COVID‐19Review Published on 2021-06-112023-06-14 Journal: Basic & clinical pharmacology & toxicology [Category] MERS, SARS, [키워드] coronavirus COVID‐19 Drug repurposing in vitro in vivo and in silico [DOI] 10.1111/bcpt.13600 PMC 바로가기 [Article Type] Review
Integrating Proteomics for Facilitating Drug Identification and Repurposing During an Emerging Virus PandemicArticle Published on 2021-06-112023-07-12 Journal: ACS Infectious Diseases [Category] SARS, [키워드] COVID-19 Drug repurposing emerging viruses kinase inhibitors kinome Pandemics proteomics SARS-CoV-2 [DOI] 10.1021/acsinfecdis.0c00579
Therapeutic Targeting of Transcription Factors to Control the Cytokine Release Syndrome in COVID-19Pharmacology Published on 2021-06-072022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] approved drugs Bronchoalveolar lavage fluid Cell Combination contribute Control correlated COVID-19 COVID-19 patients CRS cytokine cytokine production Cytokine release syndrome Cytokine storm downregulating drug Drug repurposing Efficacy expression data Factor FDA approved Drugs Gene regulatory networks hospitalized COVID-19 patients identify Inflammatory cytokine inflammatory cytokine production inhibited Interaction interactions investigated involved Pathogenesis regimen Release resource SARS-CoV2 significantly single-cell RNA-seq synergistic target targeting TFS the disease therapeutic therapeutic effect therapeutic targeting transcription factor transcriptional regulator transcriptional regulators treat upregulated [DOI] 10.3389/fphar.2021.673485 PMC 바로가기 [Article Type] Pharmacology
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions약물 용도 스크린 스크린은 Covid-19 개입의 개발을위한 화학 기관을 식별합니다.Article Published on 2021-06-032022-08-31 Journal: Nature Communications [Category] MERS, SARS, 변종, 신약개발, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity block Calu-3 calu-3 cells candidate caused Cell cell line cell lines class combination therapies Compound compounds coronavirus COVID-19 direct-acting antiviral Direct-acting antivirals drug library Drug repurposing expressing hamsters HeLa cell HeLa cells high-content imaging High-throughput screening Host host cell identify in vitro activity Infection inhibiting inhibitors inhibitors of SARS-CoV-2 Intervention lung epithelial mechanism nelfinavir pandemic parent pharmacokinetic primary cell prodrug profiles Prophylactic receptor ACE2 reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 replication sensitivity targets therapeutic drug Viral viral infection virus entry [DOI] 10.1038/s41467-021-23328-0 PMC 바로가기 [Article Type] Article
Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?선택적 세로토닌 재흡수 억제제의 약물 용도 변경: 이 약물이 COVID-19와 싸우고 생명을 구하는 데 도움이 될 수 있습니까?Review Published on 2021-06-012022-08-31 Journal: Journal of clinical neuroscience : official journa [Category] MERS, 신약개발, 치료제, [키워드] 2019 novel coronavirus absence Affect Anti-inflammatory antidepressant Antidepressant drugs antiviral properties attenuate CCL-2 class clinical trials confirmed case coronavirus disease COVID-19 COVID-19 patients curative treatment Cytokines death disease drug Drug repurposing effective Emerging infectious disease Evidence Fluoxetine focus help identify IL-6 immune system immunomodulatory Infectious disease life management mental health morbidity Neurological complication Neurological complications Novel coronavirus novel coronavirus disease pandemic present pro-inflammatory Quality of life reduce reducing reported Safe SARS-CoV-2 selective Selective serotonin reuptake inhibitors (SSRIs). Serotonin serotonin reuptake inhibitor serotonin reuptake inhibitors tested therapeutic therapeutic agent therapeutic strategy TNF-α Tolerability Vaccine widespread [DOI] 10.1016/j.jocn.2021.03.010 PMC 바로가기 [Article Type] Review
Using integrated computational approaches to identify safe and rapid treatment for SARS-CoV-2Article Published on 2021-06-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] binding energy binding pocket binding site can be used computational approach conducted coronavirus covalent bond covalent docking Cys145 docking drug Drug repurposing effective Effectiveness evaluate facilitate FDA approved drug Gromacs highest identify in silico MD simulation medication Molecular dynamics simulation MPro oseltamivir PCA provide Remdesivir Ritonavir Safe SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro stability submitted therapy Treatment Wuhan, China [DOI] 10.1080/07391102.2020.1764392 PMC 바로가기 [Article Type] Article