IFN – Page 30 – Communicable Diseases Research

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

Research Article

Published on 2014-12-222022-10-28
Journal: BMC Genomics [Category] Coronavirus,

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

Research

Published on 2014-12-072022-10-28
Journal: Virology Journal [Category] Coronavirus,

[키워드] Activation activity blocked chromatin immunoprecipitation complex interaction contribute coronavirus dependent on DNA binding downstream DUB EMSA engage experiment expressing Factors Host identify IFN Infection inhibit inhibited inhibiting inhibition activity innate immune innate immune response Innate immunity interferon IRF3 mechanism Mutagenesis mutant nuclear outcome Pathogenesis pathway Phosphorylation Plasmid PLPro potential mechanism protease Protein regulate regulated Result SARS Coronavirus SARS-CoV Severe acute respiratory syndrome shift shown Signaling Type I IFN type I interferon viral infection
[DOI] 10.1186/s12985-014-0209-9 PMC 바로가기 [Article Type] Research

Production of interferon α and β, pro-inflammatory cytokines and the expression of suppressor of cytokine signaling (SOCS) in obese subjects infected with influenza A/H1N1

Article

Published on 2014-10-012023-06-25
Journal: Clinical nutrition (Edinburgh, Scotland) [Category] 신종인플루엔자,

[키워드] IFN Influenza obesity SOCS3 TLR.
[DOI] 10.1016/j.clnu.2013.10.011

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Article

Published on 2014-08-022022-11-01
Journal: Virus research [Category] Coronavirus,

[키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection
[DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article

High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in piglets

Research Article

Published on 2014-03-282022-10-28
Journal: BMC veterinary research [Category] Coronavirus, MERS,

[키워드] added addition Apoptosis cause chloride Concentration control group coronavirus cytokine decrease detectable diarrhea Diseases down-regulation Electrophysiology epithelial evaluate the effect fecal Fecal consistency Final gastroenteritis group groups humoral immune response IFN in vivo incidence Infection interferon intestinal intestinal tract mechanism mitigate Morphometry mucosal immune OAS oral physiological PROTECT protective effect receiving reduce response Result secretion serum antibody response severity shown SLC30A1 SLC30A5 SLC39A4 stimulate TGEV three group transmissible gastroenteritis virus villus virus virus infection was performed Zinc zinc oxide Zinc transporters
[DOI] 10.1186/1746-6148-10-75 PMC 바로가기 [Article Type] Research Article

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

Research Article

Published on 2014-03-142022-10-29
Journal: Protein & Cell [Category] Coronavirus,

Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?

Research Article

Published on 2014-02-142022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

[키워드] absence adaptive Adaptive immune response Antigen presentation Antiviral approach BAL Bench Can Cell chemokine compared Consensus control patients coronavirus Critical cytokine decrease determine died different dsRNA early stage enzyme-linked immunosorbent highlight humans IFN IFNα IFNγ IL-12 IL-17 immune response impair in vitro Infected infected patient Infection initial intensive care involved mechanism MERS-CoV MERS-CoV infection Middle East National Occurrence outcome Patient polymerase chain promote respiratory response RNA robust secretion sera supernatant therapeutic approaches Treatment viral dsRNA viruses was performed were used World Health Organization
[DOI] 10.1371/journal.pone.0088716 PMC 바로가기 [Article Type] Research Article

Plasmacytoid dendritic cells and CD8 T cells from pregnant women show altered phenotype and function following H1N1/09 infection

Article

Published on 2013-10-012023-06-25
Journal: The Journal of Infectious Diseases [Category] 신종인플루엔자,

[키워드] CD8 T cell CD86 H1N1/09 HLA-DR IFN PD1 pDCs PDL1 PDL2 Pregnancy
[DOI] 10.1093/infdis/jit296

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

MicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다

Research Article

Published on 2013-02-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while
[DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article

CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection

Research Article

Published on 2012-05-172022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] absence Activation administration anti-viral response Author blocker Cancer CD200 clearance clinical trial Control dependent on determine determined different disease disease symptom ENhance Factor female female patient females Host humans Hypothesis IFN immune immune inhibitory immune response immune system immunological impair implication IMPROVE in vitro in vivo Infection influenza A virus Influenza virus inhibit inhibitory inhibitory signal lack Ligand lung MHV mice microbial infection mouse hepatitis neutrophil observé outcome overactive pathogen pathology pathway predict Prevent provided receptor receptors Release reported response Sex Sex difference Signaling supported suppresse therapeutic targeting therapeutic use threshold TLR7 Treatment Type I IFN type I interferon viral clearance viral infection virus virus infection
[DOI] 10.1371/journal.ppat.1002710 PMC 바로가기 [Article Type] Research Article