Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infectionArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 anti-RBD antibodies antibody Antibody Response BNT162b2 booster Cohort dose Frequency highest IgG antibody immune response implication individual infected individual Infection investigated lowest magnitude natural infection persistence post vaccination Protein receive remained robust S1 and S2 SARS-CoV-2 protein second dose significantly higher Sinopharm subsequent the N protein the RBD the SARS-CoV-2 virus total antibody uninfected vaccinee vaccinees were infected [DOI] 10.1371/journal.pone.0274845 PMC 바로가기
Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 TreatmentArticle Published on 2022-10-122022-11-15 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] acute respiratory syndrome Analysis analyzed anti-SARS-CoV-2 antibody Antibody Response association Blood CD19 CD3 CD4 CD8 CD8 T cell CD8 T-cell response cellular center clinical decision Cohort collected conducted coronavirus coronavirus disease correlated cross-sectional Defense evaluate Germany humoral immune response Humoral response immune response Immunoglobulin Infection interferon-γ interval lymphocyte counts matter Multiple multiple sclerosis Patient peptide pools receiving regulated response responses Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination sclerosis significantly increased Spike protein Status post subpopulation T cell T-cell the timing Treatment vaccination vaccination response Vaccination strategy variants of concern were measured [DOI] 10.1212/NXI.0000000000200031 PMC 바로가기
Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2Article Published on 2022-10-122022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated T cell antibodies antibody Antibody Response booster booster dose booster vaccination CD137 CD69 CD8 T cell Cellular immune response ChAdOx1-S conducted decrease dose expressing expression Frequency humoral IFN-γ immune response immunosuppressive increase in indicated Infection Injections lack longitudinal analysis memory monocyte mRNA mRNA vaccine myeloid cell omicron participant PD-L1 peptides phenotype producing protective immunity reactive reduced SARS-CoV-2 SARS-CoV-2-specific T cell T cell T cell response T cells the spike protein TNF-α upregulation vaccination Vaccinations Vaccine variant vector vaccine virus-specific T cell [DOI] 10.3389/fimmu.2022.1012526 PMC 바로가기
Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritisArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] addition age anti-CD20 therapy anti-S anti-S antibody anti-SARS-CoV-2 antibodies antibody Antibody Response BNT162b2 cell-mediated response Cellular immune response cellular immune responses ChAdOx1 Concentration Corona covariate adjustment COVID-19 COVID-19 vaccine declined dependent on DMARD (disease-modifying antirheumatic drug treatment) domains dose enrolled Factor healthy controls humoral IL-6 inhibitor immune response Infection inhibited investigated IQR magnitude median time mRNA-1273 Patient patients patients treated peptides positive patient reduced respiratory rheumatoid arthritis RNA RNA vaccine SARS-CoV-2 significant effect significantly Specific specific antibodies specific antibody subject T-cell T-cell Response targeted therapy the healthy the interferon the SARS-CoV-2 the vaccine therapy vaccination Vaccine variables was measured were infected [DOI] 10.3389/fimmu.2022.960001 PMC 바로가기
When the Dust Has Settled: Calculation of Binding Affinities from First Principles for SARS-CoV-2 Variants with Quantitative AccuracyArticle Published on 2022-10-112022-11-16 Journal: Journal of chemical theory and computation [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy ACE2 active against acute respiratory syndrome affinity angiotensin-converting enzyme 2 antibodies antibody applied Beta binding binding free energy biological processe calculation complex coronavirus coronavirus disease Delta delta variant Diversity dust effective estimate host cell Immune escape immune response information methodology molecular omicron Perspective Predictive principle receptor robust SARS-CoV-2 Support the binding affinity the receptor-binding domain Therapies Transmissibility variant variants widespread wild type [DOI] 10.1021/acs.jctc.2c00604 PMC 바로가기
The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccinationArticle Published on 2022-10-112022-11-15 Journal: Immunity [Category] COVID19(2023년), SARS, 진단, [키워드] age Analysis antigen-reactive T cell enrichment antigen-specific CD4+ T cells arising cause CD154 CD4 CD4+ CD40L contribute correlated COVID-19 defined determine exclusion generate heterogeneity highlight host-response immune response Immunoglobulin induce Infection intrinsic memory T cells pathogen responses SARS-CoV-2 subsequent T cell T cell receptor T cell response T cells TCR TCR tracking vaccination Variability [DOI] 10.1016/j.immuni.2022.08.003 PMC 바로가기
Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsArticle Published on 2022-10-072022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Affect Alter antibody Antibody Response Antigen antigen exposure antigenic B.1.1.529 boost chronic conditions chronic infection clinical history Cohort COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibody cross-reactivity defined described detectable Diseases epitope glycoprotein healthy high mutation rate highly antigenic immune response immunogenic individual mechanism mutations naïve individual neurological omicron overlapped Pathogens resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike protein serum antibody severe COVID-19 specificity Spike protein Subsequent infection target the antibody response understanding vaccination variants of SARS-CoV-2 Viral antigen virus viruses [DOI] 10.1038/s41598-022-20849-6 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long termArticle Published on 2022-10-062022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Admission age Analysis anti-SARS-CoV-2 IgM assessment correlated correlation difference Elderly patient evaluate evaluated event group help higher risk Hospital admission hospital discharge identify immune response implication individual Inpatient marker median time medium morbidity Mortality Older oxidative stress parameter Patient plasma Plasma level predictor prognostic Protein quantified reactive reduced RT-qPCR SARS-COV-2 infection TBARS were assessed women [DOI] 10.1371/journal.pone.0268871 PMC 바로가기
SARS-CoV-2 Papain-Like Protease: Structure, Function and InhibitionArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent antiviral immune response antivirals coronavirus COVID-19 derivatives Epidemic function Host immune response immune immune response in viral inhibition involved ISG15 less MERS-CoV motif other coronaviruses Papain-like protease posttranslational modifications protease protease inhibitors Replication SARS-CoV-1 SARS-CoV-2 Structure targets variants of concern variants of SARS-CoV-2 Viral protein [DOI] 10.1002/cbic.202200327 PMC 바로가기