proteomics – Page 30 – Communicable Diseases Research

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

장기간 COVID-19/PASC(Post-Acute Sequelae of COVID-19)의 지속적인 응고 단백질 병리는 항플라스민 수치 증가를 동반합니다

Original Investigation

Published on 2021-08-232022-09-10
Journal: Cardiovascular Diabetology [Category] MERS, SARS, 진단, 치료기술,

Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells

Article

Published on 2021-08-222022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 receptor airway Analysis angiotensin-converting enzyme 2 bind bioenergetics caused CCL5 Cell changes component conditions COVID-19 Critical CXCL10 downregulated Effect elevated elicit endothelial Endothelial cell Endothelium entry receptor epithelial evaluated Express expression Extracellular matrix hemoglobin HIF-1α homeostatic Host hypoxia hypoxic hypoxic conditions ICAM-1 IL-1β incubated infect Inflammatory Interaction Lysosomes majority metabolism Mild mitochondrial normoxic oxygen oxygen tension Protein proteomics pulmonary Quantitative reactive oxygen specy receptor reduced regulated ROS SARS-CoV-2 Severe case Signaling signaling pathway spike Spike protein the spike protein Treatment VCAM-1 virus
[DOI] 10.3390/ijms22169041 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites

SARS-CoV-2 단백질은 헤모글로빈과 그 대사산물에 결합합니다

Article

Published on 2021-08-212022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption affinity column Analysis analyzed approaches bind binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain explain FIVE hematological heme hemin hemoglobin identify in silico analysis in vitro inhibitory effect Interaction M metabolite Microarray motif motifs N N protein N-terminal domain Nsp3 Nsp7 NTD nucleoprotein peptide peptides Plaque assay Protein protein–protein binding Proteins proteomic Proteomic analysis proteomics protoporphyrin RBD RBD region receptor recruit recruitment Replication respiratory S protein SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus spike Spike protein suppressed the N protein the RBD the S protein the spike protein these compound these compounds Vero cells Viral viral replication virus was used
[DOI] 10.3390/ijms22169035 PMC 바로가기 [Article Type] Article

A time-resolved proteomic and prognostic map of COVID-19

Covid-19의 시간 분해 된 단백질 학적 및 예후지도

Article

Published on 2021-08-182022-08-31
Journal: Cell Systems [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] Abstract age asymptomatic infection Biomarkers blood cell blood cell count blood cell counts characterized clinical disease progression clinical parameter Clinical parameters Cohort COVID-19 COVID-19 progression death diagnostic disease phenotype disease prognosis enzyme activities followed by host response identify immunomodulation independent Infectious disease initial Inpatient longitudinal profiling machine machine learning machine learning model machine learning models molecular organ damage parameter parameters patient trajectories patients with COVID-19 phenotype physiological parameters plasma Predictive prognostic Prognostic marker progression Protein proteome proteomic proteomics specificity systemic inflammatory response the disease therapeutic tissue repair Treatment strategies treatment strategy
[DOI] 10.1016/j.cels.2021.05.005 PMC 바로가기 [Article Type] Article

Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx

비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명

Research

Published on 2021-08-142022-09-10
Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research

Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants

Review

Published on 2021-08-122022-11-01
Journal: Clinical Proteomics [Category] COVID-19,

[키워드] acute respiratory syndrome anti-viral antibody assays Betacoronavirus clinical study Combination continuous monitoring coronavirus coronavirus disease COVID-19 cross-reactivity diagnostic Diseases Emerging mutations evaluate facilitate functional identify Immunity immunoassays immunoprecipitation information knowledge mass mass spectrometry molecular diagnostics mutant mutations pandemic Pandemics Perspective Population post-translational modifications Protein protein–protein interactions proteomic proteomics quantification rapid response Research RNA sequencing RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serology diagnostics serology test specificity targeted proteomics translational Viral protein Viral RNA viruses while
[DOI] 10.1186/s12014-021-09325-x PMC 바로가기 [Article Type] Review

A Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients

Article

Published on 2021-08-112023-06-16
Journal: Journal of Proteome Research [Category] MERS, SARS,

[키워드] COVID-19 longitudinal mass spectrometry metabolomics proteomics SARS-CoV-2
[DOI] 10.1021/acs.jproteome.1c00215 PMC 바로가기 [Article Type] Article

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

시리아 햄스터의 시간적 omics 분석은 중간 정도의 COVID-19에 대한 세포 효과기 반응을 풉니다.

Article

Published on 2021-08-112022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법,

[키워드] Adaptive immunity alterations Analysis Anti-viral blood sample Blood samples Cell cellular cellular mechanism cellular mechanisms Cellular responses COVID-19 COVID-19 patients COVID19 Cytotoxic T cell Cytotoxic T cells dataset datasets disease severity Endothelial cell endothelial cells epithelial cell epithelial cells Evidence expression functions Genes hamster identify IgM antibodies IgM antibody immune response immune responses Infection inflammatory lung injury Innate immunity longitudinal analysis lung Lung injury Lungs Macrophage macrophages Mechanisms of disease Moderate COVID-19 monocyte Monocyte-derived macrophages Pathomechanism Pathomechanisms post infection pro-inflammatory Pro-inflammatory genes proteomics response SARS-CoV-2 SARS-COV-2 infection scRNA-seq Subtypes T cell T cells Temporal Therapeutic strategies transcriptional response Viral viral clearance viral infection
[DOI] 10.1038/s41467-021-25030-7 PMC 바로가기 [Article Type] Article

Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donors

Original Article

Published on 2021-08-062022-10-30
Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS,

[키워드] activated T cell activated T cells activating acute respiratory syndrome Analysis analyzed B cell B‐cell Biliary CCR2 CD8 cellular response chemotactic convalescent plasma coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CX3CR1 cytokine cytokine production Cytokines disease Donor endothelial expected expression flow cytometry group growth healthy individual healthy subjects IL‐6 Immune cell immune cells immune response Immunity Infection infiltration Inflammatory marker inflammatory monocyte inflammatory protein inhibitory Leptin Ligand Lung injury Macrophage main mechanism Migration Mild MIP moderate monocyte Monocyte activation Monocytes New Patient patients performed Plasma cytokine positive Protein Proteins proteomics receptor recovered patient recovered patients recruited reduction in Result Saa1 serum significant increase sustained T cells target tissue Vascular
[DOI] 10.1002/iid3.476 PMC 바로가기 [Article Type] Original Article

Proteomic and metabolomic investigation of serum lactate dehydrogenase elevation in COVID-19 patients

COVID-19 환자의 혈청 젖산 탈수소효소 상승에 대한 단백질체 및 대사체 연구

Article

Published on 2021-08-012022-09-11
Journal: Proteomics [Category] 유전자 메커니즘,

[키워드] Activation Admission biochemical Biomarker Blood coagulation cascade clinical and laboratory parameters complement Complement cascade consequence COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity declined degranulation differential expression differentially expressed disease course elevated enrolled exhibited expression expressions group hypoxia immune response immune responses Inflammation Inflammatory responses laboratory parameter Lactate lactate dehydrogenase LDH lipid metabolism metabolism metabolomic metabolomics molecular mechanism molecular mechanisms MONITOR Patient patient severity Platelet Prognosis prognostic indicator protein ubiquitination proteomic proteomics pyruvate Quantitative response serum serum lactate severity shown subset threshold tissue injury was determined with COVID-19
[DOI] 10.1002/pmic.202100002 PMC 바로가기 [Article Type] Article