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[키워드] 95% CI adverse event adverse events AEs AEsAdverse events anti-S IgG anti-SARS-CoV-2 antibody binding Citadel clinical development Clinical research collected Concentration conducted COVID-19 COVID-19 vaccine dose Dose escalation earth effective ELISA enrolled enrolment EudraCT facility finding Follow-up force funding gene of Interest geometric mean GOIgene of Interest healthy individual Humoral response IgG ELISA immunoblot immunogenic induce injection interval intramuscular Joseph Lipid Lipid nanoparticle LNP LNPlipid nanoparticle London low dose low dose vaccine Medical Research Council neutralisation neutralisation assays non-structural protein NSPnon-structural protein Open-label participant partner Phase I post-hoc raised ranged required RNA RNA vaccine Safe Safety saRNAself-amplifying RNA SARS-CoV-2 self-amplifying RNA sera Serious Adverse Event Seroconversion serological evidence Trial Trust vaccination Vaccine VEEVVenezuelan equine encephalitis virus Venezuelan equine encephalitis virus was measured was related wild type
[DOI] 10.1016/j.eclinm.2021.101262 [Article Type] Research article