Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-ReviewCOVID-19 치료에 대한 클로로퀸 및 하이드록시클로로퀸 이독성의 임상적 의미: 미니 리뷰Review Published on 2020-05-292022-09-11 Journal: Frontiers in Public Health [Category] SARS, 치료제, [키워드] auditory Autoimmune diseases Characteristics Chloroquine clinical clinical trial clinical trials COVID-19 COVID-19 infection COVID-19 pandemic damage dose drug dysfunction Effect effective greater hearing loss Hydroxychloroquine hydroxychloroquine treatment Imbalance implication inner ear Intervention lAbel malaria Newborn off-label off-label use ototoxic ototoxicity pregnant women protocol reported sensorineural hearing loss structures suggested survivor tinnitus treated Treatment Trial urgent investigation usual dosage [DOI] 10.3389/fpubh.2020.00252 PMC 바로가기 [Article Type] Review
Alternative Care Sites: An Option in DisastersEndemic Infections Published on 2020-05-132022-10-28 Journal: Western Journal of Emergency Medicine [Category] Coronavirus, SARS, [키워드] administration Care Community COVID-19 pandemic criteria Developing disaster equipment Healthcare system Local magnitude occur option Situated structures variety [DOI] 10.5811/westjem.2020.4.47552 PMC 바로가기 [Article Type] Endemic Infections
Spatio-Temporal Resource Mapping for Intensive Care Units at Regional Level for COVID-19 Emergency in ItalyArticle Published on 2020-05-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] affected analysed China country COVID-19 COVID-19 patient Critical Data analysis Emergency Government Health ICU ICUs intensive care unit Italian Italian regions Italy Level Lombardia management mapping North prediction of infected Regional resources Severe case Spread Structure structures Support Veneto [DOI] 10.3390/ijerph17103344 PMC 바로가기 [Article Type] Article
Demographic science aids in understanding the spread and fatality rates of COVID-19524 Published on 2020-05-052022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, MERS, SARS, [키워드] age age and sex Age structure coronavirus disease country COVID-19 Critical care death demographic demography explain fatality Fatality rate help highlight Hospitalization IMPROVE Interaction interactions Italy Local mitigate Mortality National Older pandemic Population populations social distancing South Korea Spread structures Transmission [DOI] 10.1073/pnas.2004911117 PMC 바로가기 [Article Type] 524
Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans530 Published on 2020-01-212022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, [키워드] Activation alphacoronavirus analyses Analysis cause cleavage site complex protein coronavirus spike protein CoV cryo-EM cryo-EM structure Cryoelectron microscopy demonstrated domain effective feasibility feature Feline infectious peritonitis Feline infectious peritonitis virus glycan glycosylation high-mannose highlight Host mass spectrometry Microscopy molecular mortality rate N-glycan Pathogenesis Protein protein glycosylation provided reported responsible resulting reveal S protein S proteins S2 subunit serotype Significance structures the S1 subunit Treatment unique viral entry virus [DOI] 10.1073/pnas.1908898117 PMC 바로가기 [Article Type] 530
Comprehensive structural variation genome map of individuals carrying complex chromosomal rearrangements복잡한 염색체 재배열을 가진 개인의 포괄적인 구조적 변이 게놈 지도Research Article Published on 2019-02-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] analyzed Author breakpoint Case series case sery CCR chromosomal rearrangement chromosome chromosome 1 chromosome 10 chromosome 2 chromosomes clinical setting clinical symptom Clinical symptoms complementary complex Comprehensive de novo Deletion demonstrated diagnostic disease disrupting experiment FIVE Genes Genetic Genome genomic high resolution individual karyotyping Laboratory molecular nucleotide optical phenotype power problem problems Region resolved sensitivity sequence Sequencing Structural variation Structure structures the patient unique was obtained WGS whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007858 PMC 바로가기 [Article Type] Research Article
Crystal structure of the post‐fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolutionResearch Papers Published on 2018-09-102022-10-27 Journal: Acta crystallographica. Section D [Category] Coronavirus, MERS, [키워드] addition Adults appear cause comparison Complete conserved coronavirus coronavirus 229E crystal structure electrostatic electrostatic interaction facilitate HCoV‐229E heptad repeat host cell host membranes Human human coronavirus hydrophobic hydrophobic interaction immune systems individual inhibit inhibitor Interaction involved MERS Mild Mortality opposite peptide polar post‐fusion core preserved Protein representing reveal S1 domain S2 domain SARS severe complication small molecule Spike protein structures subsequent surface potential upper respiratory infection virus was determined weakened X‐ray structure [DOI] 10.1107/S2059798318008318 PMC 바로가기 [Article Type] Research Papers
Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane PairingArticle Published on 2018-09-062022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] bronchitis Cell cellular membrane Combination coronavirus Coronaviruses Effect electron tomography Endoplasmic reticulum expressing expression Factor highlight Host IBV indicate induce Infectious Bronchitis Virus investigated mechanism membrane membrane rearrangements membrane vesicle Microscopy non-structural protein Nsp3 nsp4 Nsps organelle paired membranes Pairing pathogenic Proteins Replication replicative required responsible RNA viruses shown spherules strain structures transmembrane transmembrane protein vesicles Viral protein viral RNA synthesis virus were expressed zippered ER [DOI] 10.3390/v10090477 PMC 바로가기 [Article Type] Article
Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus NanoparticlesImmunology Published on 2018-05-172022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] affected aggregation Antigen assembly Bacterial binding cellular receptor chaperone Concentration conformations contributed Control defined domain effective Escherichia coli expressed expression favor ferritin fused hDPP4 hosts immunization immunologically in silico in vitro Interaction kinetic lack linker Lysyl-tRNA synthetase MERS-CoV MERS-CoV RBD Microscopy Middle East Middle East respiratory syndrome Coronavirus molecular monomer monomeric Mutation nanoparticle pathway platform presenting proteolytic RBD Receptor-binding domain recombinant vaccine reducing respiratory RNA RNA-interacting domain of human LysRS robust scattering sera serological significantly increased stability Structure structures subsequent Vaccine viral infections Virus-like particle [DOI] 10.3389/fimmu.2018.01093 PMC 바로가기 [Article Type] Immunology
Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic RegionsPrion 균주의 광범위한 다양성은 차등 샤페론 상호 작용 및 고유한 아밀로이드 생성 영역에 의해 정의됩니다Research Article Published on 2014-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregates aggregation amyloid Analysis canonical chaperone cofactor cofactors complex conformation conformational conformational change consequence Critical determinant disease disease pathology Disease progression Diseases disorders Diversity domain element examined Extensive Factor help Host Hypothesis induce Interaction involved manifestation modulating molecular neurodegenerative pathology phenotypic phenotypic variation prion progression Propagation Protein Proteins provided PSI Region responsible stability strain Strains structures Support These data Transmission unique Variability variant variants Variation variety widespread yeast [DOI] 10.1371/journal.pgen.1004337 PMC 바로가기 [Article Type] Research Article