Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector systemReview Published on 2020-09-192023-07-01 Journal: Microbes and infection [Category] SARS, [키워드] BCG COVID-19 RBD domain SARS-CoV-2 Vaccines [DOI] 10.1016/j.micinf.2020.09.004 PMC 바로가기 [Article Type] Review
Primed for global coronavirus pandemic: Emerging research and clinical outcomeReview Published on 2020-09-192023-06-14 Journal: European journal of medicinal chemistry [Category] MERS, SARS, [키워드] ACE2, Angiotensin-converting enzyme-2 antiviral drugs clinical trials CoV, coronaviruses COVID-19 Drug repurposing MERS-CoV, middle east respiratory syndrome virus monoclonal antibodies RdRp, RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 small molecule drugs Vaccines [DOI] 10.1016/j.ejmech.2020.112862 PMC 바로가기 [Article Type] Review
Conspiracy Beliefs, Rejection of Vaccination, and Support for hydroxychloroquine: A Conceptual Replication-Extension in the COVID-19 Pandemic ContextPsychology Published on 2020-09-182022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] Affect attitude toward science Chloroquine conducted conspiracy beliefs conspiracy mentality Context COVID-19 COVID-19 pandemic COVID–19 cross-sectional study examined exploratory study Intention pandemic pandemic (COVID-19) predicted predisposition replicated response Support Treatment treatment for COVID-19 vaccinated against COVID-19 vaccination vaccination intention vaccination intentions Vaccine Vaccines [DOI] 10.3389/fpsyg.2020.565128 PMC 바로가기 [Article Type] Psychology
A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling ApproachArticle Published on 2020-09-182022-10-28 Journal: Biology [Category] COVID-19, [키워드] accelerate Adaptive immune response adjuvant Analysis approved B-cell candidate cause caused checked China Comprehensive coronavirus COVID-19 demonstrated development Efficacy Escherichia coli expression globe Helicase help immunization in silico In silico cloning include infections initial Interaction lack linkers molecular molecular dynamics Molecular dynamics simulation molecular interaction Molecular modeling multiepitope vaccine multiple epitope non-structural protein novel Novel coronavirus outbreak pandemic Pathogens peptide polymerase Prophylactic protease protective immunity Repurposed drugs Research SARS-CoV-2 SARS-CoV-2 protein severe respiratory infection simple solution Spike protein Spread stability T-cell epitope three-dimensional structure TLRs Toll-like receptor Treatment triggering urgency Vaccine vaccine construct Vaccine design Vaccine development vaccine production Vaccines virus was used World Health Organization [DOI] 10.3390/biology9090296 PMC 바로가기 [Article Type] Article
Repurposing current therapeutic regimens against SARS-CoV-2 (Review)Review Published on 2020-09-182022-10-31 Journal: Experimental and Therapeutic Medicine [Category] COVID-19, [키워드] angiotensin-converting enzyme 2 Antarctica Anti-inflammatory antimalarial antiparasitic Antiviral clinical trials Community coronavirus COVID-19 COVID-19 pandemic drugs evaluate Experimental drugs immunization inhibitors mechanism of action outbreak pandemic Perspective Prophylactic regimen regimens repurposing Research review SARS-CoV-2 Spread therapeutic therapeutic efficacy Therapeutic treatment Treatment urgency vaccination Vaccines [DOI] 10.3892/etm.2020.8905 PMC 바로가기 [Article Type] Review
Antibodies and Protection in Systemic Salmonella Infections: Do We Still Have More Questions than Answers?전신 살모넬라 감염에서 항체와 보호: 우리는 여전히 답보다 더 많은 질문이 있는가?Article Published on 2020-09-182024-08-21 Journal: Infection and Immunity [Category] 살모넬라증, [키워드] antibodies IgA IgG IgM Salmonella systemic infections Vaccines
Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in SilicoBrief Report Published on 2020-09-172022-10-28 Journal: Toxins [Category] COVID-19, SARS, [키워드] antibody Antiviral antiviral agent binding mechanism caused chain characterized COVID-19 docking docking result experiment functions fusion fusion protein fusion proteins high affinity in silico mice New coronavirus novel pandemic pokeweed antiviral protein Protein protein-ligand Proteins Range ribosome-inactivating proteins ricin SARS-CoV-2 Structure target the SARS-CoV-2 therapeutic Therapies Toxicity Vaccines virus [DOI] 10.3390/toxins12090602 PMC 바로가기 [Article Type] Brief Report
Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in DenmarkLetter Published on 2020-09-172022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 24 hour Administered administration age All participant allergy anti-cytokine therapy approved asked Bacterial infection BCG BCG vaccination blinded to treatment block Bone marrow Chemotherapy component Controlled trial COVID-19 COVID-19 pandemic criteria cumulative current daily dose Day defined Denmark Direct dissemination dose Effect element eligible ENhance EudraCT excluded exclusion group HCW Health care Health care worker HIV-1 hospital Hospital admission hospitals Human immunodeficiency virus Immunocompromised immunodeficiency incidence Inclusion infected with SARS-CoV-2 Infection infections Infectious disease injection Intervention intravenous lymphoma malignancy Medicine meet morbidity and mortality mycobacterial Mycobacterium tuberculosis NaCl solution non-specific not blinded number participant physician Placebo Prednisone Prevent protective effect protocol random randomisation randomised randomised controlled trial receive recruit reduce reductions in Registered reported resuspended Sample secondary Serious Adverse Event severity of COVID-19 Sex solid organ transplantation steroid Stratification study participant Study protocol subject subjects susceptibility suspicion Treatment Trial Tuberculosis Vaccine Vaccines website [DOI] 10.1186/s13063-020-04714-3 PMC 바로가기 [Article Type] Letter
Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-21001 Published on 2020-09-162022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] analyses antigen processing Belonging Betacoronavirus computational tools conserved Contact contagious coronavirus creating Cytokine storm drug effective epitope Epitope-based vaccine Epitopes helper T cell humans Hyperactivation immune response immunogenic immunoinformatics immunopathology in vitro information novel novel coronavirus SARS-CoV-2 pandemic pathogen pathway Protein Proteins provide SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteome Spread Stage survival symptomatic and asymptomatic T cell T cell epitopes the SARS-CoV-2 Transmission Treatment unique Vaccine Vaccines Viral protein [DOI] 10.1098/rsos.201141 PMC 바로가기 [Article Type] 1001
Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine DevelopmentBacillus Calmette-Guérin의 교훈: 백신 개발을 위한 훈련된 면역 활용Review Published on 2020-09-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, 진단, [키워드] Adaptive immune response adaptive immune responses Bacillus Bacillus Calmette-Guérin (BCG) Bacillus Calmette-Guérin BCG development Effect evade examined expand immune responses Immunity IMPROVE induce Infection innate immune innate immune memory lesson lower mortality mechanism microbe mucosal immunity Mycobacterium tuberculosis paradigm Pathogens pathway phenotype required target pathogen Tuberculosis Vaccine Vaccine design Vaccines [DOI] 10.3390/cells9092109 PMC 바로가기 [Article Type] Review