Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccineArticle Published on 2020-08-242022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] accelerated acute respiratory syndrome approach caused clinical trial coronavirus Coronavirus disease 2019 correlated COVID-19 disease effective effective drug effective therapy effective vaccine Efficacy Evidence Immunopathogenesis Infectious disease morbidity Mortality Novel coronavirus overcome pandemic required SARS-CoV-2 therapeutic Treatment Vaccine vaccine production Vaccines Viral diseases virus worsening [DOI] 10.1016/j.intimp.2020.106928 PMC 바로가기 [Article Type] Article
Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 ComplexArticle Published on 2020-08-242022-10-27 Journal: ACS Nano [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome allelic variant angiotensin-converting enzyme 2 Blood cellular receptor computational alanine-scanning mutagenesis contributing to coronavirus coronavirus disease COVID-19 COVID-19 patient Critical D38 determinant domain effective etiological agent free energy of binding global pandemic global public health glycoprotein homeostasis Host in silico inhibitor Interaction K31 K353 molecular mechanics/Poisson−Boltzmann surface area molecular molecular dynamics Neutralizing antibodies New coronavirus pathogen provide Q498 Quantitative R403 Receptor-binding domain residue S-protein SARS-CoV-2 SARS-CoV-2 host cell SARS-CoV-2 spike protein scanning spike stability structure-based design T500 the binding affinity the receptor-binding domain the SARS-CoV-2 transmembrane spike Vaccines Vascular Viral protein Volume [DOI] 10.1021/acsnano.0c04674 PMC 바로가기 [Article Type] Article
Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 ComplexArticle Published on 2020-08-242022-10-27 Journal: ACS Nano [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome allelic variant angiotensin-converting enzyme 2 Blood cellular receptor computational alanine-scanning mutagenesis contributing to coronavirus coronavirus disease COVID-19 COVID-19 patient Critical D38 determinant domain effective etiological agent free energy of binding global pandemic global public health glycoprotein homeostasis Host in silico inhibitor Interaction K31 K353 molecular mechanics/Poisson−Boltzmann surface area molecular molecular dynamics Neutralizing antibodies New coronavirus pathogen provide Q498 Quantitative R403 Receptor-binding domain residue S-protein SARS-CoV-2 SARS-CoV-2 host cell SARS-CoV-2 spike protein scanning spike stability structure-based design T500 the binding affinity the receptor-binding domain the SARS-CoV-2 transmembrane spike Vaccines Vascular Viral protein Volume [DOI] 10.1021/acsnano.0c04674 PMC 바로가기 [Article Type] Article
Immunotherapeutic approaches to curtail COVID-19Article Published on 2020-08-212022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 신약개발, [키워드] Abstract active immunization acute respiratory syndrome administration antibodies antibody antivirals approach associated immune response convalescent plasma coronavirus Corticosteroids country COVID-19 COVID-19 disease course curtail cytokine Defense disease stage drug Drug repurposing evaluated help Host human clinical trials identify immune evasion immune modulation immune response immune system immunomodulatory drugs Immunotherapy interferon JAK inhibitor jak inhibitors knowledge late stage monoclonal pandemic passive immunization pathogenesis of SARS-CoV-2 patients plasma plasma therapy polyclonal antibodies prevention of COVID-19 response SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome coronavirus 2 severely ill patients stages suggested suppresse the cytokine storm the disease the patient therapeutic approaches therapy Vaccine Vaccines virus [DOI] 10.1016/j.intimp.2020.106924 PMC 바로가기 [Article Type] Article
Direct-RT-qPCR Detection of SARS-CoV-2 without RNA Extraction as Part of a COVID-19 Testing Strategy: From Sample to Result in One HourArticle Published on 2020-08-182022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 2019-nCoV absence acute respiratory syndrome Antiviral approach BSL-2 comparable condition coronavirus Coronavirus disease 2019 costly COVID-19 COVID-19 infection COVID-19 testing Critical Cycling detect detection diagnostic diagnostics effective enzyme extraction General population heat inactivation help hour Implementing include involved Laboratory lack less limit of detection Local media non-infectious one-step direct RT-PCR pandemic Part performed point-of-care point-of-care testing protective immunity protocol required Result RNA RNA extraction RNA isolation RT-qPCR Sample SARS-CoV-2 screening tests sensitivity Sensitivity and specificity Seven Spread suggested Swab Testing the disease time-consuming transfer translate Vaccines virus [DOI] 10.3390/diagnostics10080605 PMC 바로가기 [Article Type] Article
Development of vaccines for SARS-CoV-2Review Published on 2020-08-172022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] applied approaches country COVID-19 develop development drug effort Government highlighting human populations natural immunity pandemic resource SARS-CoV-2 SARS-CoV-2 virus Spread Vaccine Vaccine development Vaccines [DOI] 10.12688/f1000research.25998.1 PMC 바로가기 [Article Type] Review
Gavi Support for Typhoid Conjugate Vaccines: Moving From Global Investments to Country Introduction가비의 장티푸스 결합 백신 지원: 글로벌 투자에서 국가 도입으로 이동Article Published on 2020-08-152024-07-29 Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 살모넬라증, [키워드] Enteric fever global health immunizations Typhoid conjugate vaccine Vaccines [DOI] 10.1093/cid/ciaa342 PMC 바로가기
Overview of the Nontyphoidal and Paratyphoidal Salmonella Vaccine Pipeline: Current Status and Future Prospects비장티푸스 및 파라티푸스 살모넬라 백신 파이프라인 개요: 현재 상태 및 미래 전망Article Published on 2020-08-152024-07-29 Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 살모넬라증, [키워드] NTS Paratyphi Salmonella Vaccines [DOI] 10.1093/cid/ciaa514 PMC 바로가기
The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus InfectionsImmunology Published on 2020-08-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV Anti-viral drugs clinical disease clinical feature Comparative coronavirus COVID-19 Cytokine storm disease dysfunction Evidence exhibit homologous immunological characteristics immunology Immunopathogenesis immunopathology Immunotherapy Infection knowledge mechanism MERS MERS-CoV Novel coronavirus pandemic Pathogenesis pathogenesis of COVID-19 pathogenicity patients recent finding Research responsible SARS-CoV SARS-CoV-2 Stage the disease therapeutic strategy Transmissibility Vaccines virus [DOI] 10.3389/fimmu.2020.02033 PMC 바로가기 [Article Type] Immunology
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challengeArticle Published on 2020-08-142022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] Adenovirus Adenovirus-vectored vaccine coronavirus disease COVID-19 develop effective Efficacy Epidemic expressing ferret generate human clinical trials Infection Infectious disease inhibit mice mouse-adapted SARS-CoV-2 mucosal preventing infection PROTECT Protective provide public health emergency respiratory tracts SARS-CoV-2 SARS-CoV-2 spike protein single dose single vaccination Spike protein the SARS-CoV-2 transmission of SARS-CoV-2 upper respiratory tract vaccination Vaccine Vaccines virus replication wild-type SARS-CoV-2 [DOI] 10.1038/s41467-020-17972-1 PMC 바로가기 [Article Type] Article