The highly flexible disordered regions of the SARS-CoV-2 nucleocapsid N protein within the 1–248 residue construct: sequence-specific resonance assignments through NMRArticle Published on 2021-03-032022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] 13C detection addition Analysis bioinformatics characterized Complete COVID-19 CTD domain expected expressed flexible heterogeneous High-resolution homologous host cell IDPs information investigated N protein N-terminal NMR NMR spectroscopy NTD nucleocapsid nucleocapsid protein Protein Region regions residue SARS-CoV SARS-CoV-2 the SARS-CoV-2 Transcription virion virus whole protein [DOI] 10.1007/s12104-021-10009-8 PMC 바로가기 [Article Type] Article
Reimagining patient-centered care in opioid treatment programs: Lessons from the Bronx during COVID-19Short communication Published on 2021-03-012022-10-05 Journal: Journal of substance abuse treatment [Category] 치료법, [키워드] administration Care changed clinical guideline Clinical practice COVID-19 death disorder distribution dose facilitate flexible Government initial less lesson measure Measures medication opioid OTP overdoses Pandemics Patient physical distancing Prevent promote proportion provide reduced Regulation required risk Treatment with COVID-19 [DOI] 10.1016/j.jsat.2020.108219 [Article Type] Short communication
New Approaches to Regulatory Innovation Emerging During the Crucible of COVID-19 : In Responding to a Global Health Crisis, Industry is Discovering New, Efficient Ways of Meeting ObjectivesCOVID-19의 도가니 중에 등장하는 규제 혁신에 대한 새로운 접근 방식: 세계 보건 위기에 대응하기 위해 업계는 목표를 달성하는 새롭고 효율적인 방법을 발견하고 있습니다Article Published on 2021-03-012022-08-31 Journal: Therapeutic innovation & regulatory science [Category] 신약개발, [키워드] addition Affair agency agility Bayer benefit Caregivers Clinicians Cloud-based systems coronavirus Coronavirus pandemic COVID-19 COVID-19 crisis COVID-19 pandemic crisis Crucible Decentralized trials develop efficient Evidence exhibited flexible global health Guidance head Impact IMPROVE Innovation medical need Medicines meeting New objective pandemic Patient patients pharmaceutical pharmaceutical industry platform provided Regulation Regulatory regulatory agencies regulatory agency Regulatory policy remote Remote work. Responding speed Therapies therapy trials urgency Vaccines virus [DOI] 10.1007/s43441-020-00239-8 PMC 바로가기 [Article Type] Article
Contact tracing evaluation for COVID-19 transmission in the different movement levels of a rural college town in the USAArticle Published on 2021-03-012022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] basic reproductive number benefit can be used composed Computational models Computational science confirmed case confirmed cases Contact Contact tracing contagious COVID-19 COVID-19 transmission decrease disease Effectiveness Epidemic example flexible fraction human-to-human transmission increase Network topology parameter reduce reduced Research susceptible the epidemic USA [DOI] 10.1038/s41598-021-83722-y PMC 바로가기 [Article Type] Article
European Biomedical Research Infrastructures and the Fight against COVID-19 Pandemic유럽의 생물의학 연구 인프라와 COVID-19 전염병과의 싸움Advanced Researches Published on 2021-02-282022-09-10 Journal: Modern Technologies in Medicine [Category] 유전자 메커니즘, 임상, 치료제, [키워드] Analysis analyzed Biomedical research Community COVID-19 COVID-19 pandemic development ecosystem effort ESFRI EU EU biomedical research infrastructures European European Commission facilitated flexible Forum framework information Infrastructure innovations material mechanism pathogen portal Program provided Research respond Spread treating COVID-19 [DOI] 10.17691/stm2021.13.1.01 PMC 바로가기 [Article Type] Advanced Researches
Guidelines for Robotic Flexible Endoscopy at the Time of COVID-19Robotics and AI Published on 2021-02-252022-10-31 Journal: Frontiers in Robotics and AI [Category] COVID-19, [키워드] aerosol generating procedure Aerosol generation benefit Cancer change COVID-19 deaths diagnose diagnostic diagnostic procedure endoscopes endoscopy flexible Flexible endoscopy Gastrointestinal guideline healthcare healthcare worker implication increase in infection control insertion Insufflation lockdown operator pandemic platform predicted reducing risk risk of COVID-19 robotic flexible endoscopy robotics Safe stoppage Surveillance therapeutic time Transmission Treatment virus transmission [DOI] 10.3389/frobt.2021.612852 PMC 바로가기 [Article Type] Robotics and AI
Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine CandidatesSARS-CoV-2 스파이크 단백질 수용체 결합 도메인 자가 조립 나노입자 백신 후보의 신속한 개발Article Published on 2021-02-232022-09-12 Journal: ACS Nano [Category] MERS, 진단, [키워드] ACE2 adjuvant adopted angiotensin-converting enzyme 2 Antisera binding blocked candidate caused coronavirus disease covalent conjugation COVID-19 development domain effective exhibited flexible greater Health highlight immunization immunized in vitro membrane fusion mice monomeric RBD MOST nanoparticle Nanoparticles Neutralizing activity pandemic platform produced pseudovirus Rapid RBD receptor Receptor binding Receptor binding domain resulting SARS-CoV-2 SARS-CoV-2 coronavirus sera sigma spike SpyTag-SpyCatcher System the RBD the SARS-CoV-2 the spike protein the vaccine Vaccine vaccine candidate vaccine candidates Vaccine development virus [DOI] 10.1021/acsnano.0c08379 PMC 바로가기 [Article Type] Article
Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2Article Published on 2021-02-222022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] Amino acid amino acid residue Antigen binding cell membrane COVID-19 effective flexible hACE2 hACE2 receptor highest human Angiotensin-converting enzyme immune response infection process Infectious disease Interaction investigated MD simulations mechanism Molecular modelling Mutation NMA normal mode analysis novel coronavirus SARS-CoV-2 outbreak Protein RBD receptor receptor ACE2 Receptor binding domain residue S477N SARS-CoV-2 SARS-CoV-2 mutants Spike protein the disease the RBD the SARS-CoV-2 the spike protein variant viral infection virus [DOI] 10.1038/s41598-021-83761-5 PMC 바로가기 [Article Type] Article
On the Prevalence and Potential Functionality of an Intrinsic Disorder in the MERS-CoV ProteomeArticle Published on 2021-02-222022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] 3D structure antibody approach binding caused complex contribute coronavirus disorder drug effective evaluate feature flexible function functional high mortality rate Host intrinsic intrinsically Intrinsically disordered proteins linear mechanism MERS-CoV MERS-CoV genome Middle East molecular MoRFs motifs organism Pathogenesis performed Potential Protein protein structure Proteins proteome regions severe respiratory illness SLiM Structural analysis Structure suggested syndrome Transmission Treatment Vaccine viral infection Viral protein virus [DOI] 10.3390/v13020339 PMC 바로가기 [Article Type] Article
Impact of COVID-19 on the Speech and Language Therapy Profession and Their PatientsNeurology Published on 2021-02-182022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] acute COVID-19 affected affecting Analysis analyzed approach benefit Care change college COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients database disruption theory Dysphagia flexible healthcare service Impact information Intervention language Language Therapy less outcome outcome measurement outcomes pandemic Patient patients patients with COVID-19 positive profession provided question receiving reduction in Referral response routine clinical data service provision speech speech and language therapy supported therapist therapy triggered usual care was used [DOI] 10.3389/fneur.2021.629190 PMC 바로가기 [Article Type] Neurology