Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet ReactivityMedicine Published on 2021-04-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval adjusted odds ratio ADP age all-cause mortality AOR association Asthma baseline blood sample clinical Clinical outcome control patient COVID-19 COVID-19 negative COVID-19 positive patient decrease determine develop disease enrolled expression flow cytometry followed by highlight Hospitalized hospitalized COVID-19 patient hypercoagulability incidence increased the risk less Lower nine Non-survivors outcome P-selectin Patient Platelet Platelets positive prothrombotic state provided pulmonary thrombosis reactivity retrospective cohort study risk SARS-CoV-2 significant difference survivor therapy Thromboinflammation Thromboprophylaxis thrombosis thrombotic thrombotic event Thrombotic events was determined with COVID-19 [DOI] 10.3389/fmed.2021.650129 PMC 바로가기 [Article Type] Medicine
Development of a severity of disease score and classification model by machine learning for hospitalized COVID-19 patients입원 중인 코로나19 환자를 위한 머신러닝을 통한 질병 점수 및 분류 모델의 중증도 개발Research Article Published on 2021-04-212022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] 95% CI 95% confidence interval Admission age applied AUC C-reactive protein calculator Charlson Comorbidity Index clinical and laboratory features Cohort Comorbidity COVID-19 patients detect development died Disease progression efficient estimated glomerular filtration rate evaluated filtration rate FiO2 glomerular filtration rate higher risk hospital Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients identify laboratory feature Lymphocytes machine-learning management mechanical ventilation open oxygen oxygen saturation Patient patients performance performed Peripheral blood predict procalcitonin progression required Result risk Sensitivity and specificity severe disease severe disease progression Severity of disease SpO2 stratified tested variable was used were used [DOI] 10.1371/journal.pone.0240200 PMC 바로가기 [Article Type] Research Article
Humoral immune responses in hospitalized COVID-19 patientsOriginal Article Published on 2021-04-202022-10-04 Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis anti-S IgG Anti-SARS-CoV-2 S antibodies antibody antibody isotype association caused coronavirus Coronavirus 2019 COVID-19 COVID-19 patient detect Diagnosis diagnosis of COVID-19 disease disease severity ELISA enzyme-linked immunosorbent female females Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient humoral immune response Humoral immunity IgA IgA antibodies IgA antibody IgA response IgG IgG and IgM IgM IgM antibody immune response Immunity Infection investigated isotype male material Non-severe non-severe patients participated Patient patients positive Protein public health crisis Qualitative response Result RT-PCR SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 RNA Saudi Arabia sera severe significantly significantly higher Specific the S protein the SARS-CoV-2 Variation Viral proteins virus was used were measured [DOI] 10.1016/j.sjbs.2021.04.032 PMC 바로가기 [Article Type] Original Article
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune FunctionsCOVID-19 중증도는 차등 항체 Fc 매개 선천 면역 기능과 관련이 있습니다Observation Published on 2021-04-202022-09-10 Journal: mBio [Category] MERS, SARS, 바이오마커, 진단, [키워드] Activation ADCC ADCD ADCP Anti-RBD antibodies Anti-RBD antibody Anti-S1 anti-SARS-CoV-2 antibodies binding antibody antibody-dependent cell-mediated cytotoxicity antibody-dependent complement deposition Cell-mediated cytotoxicity complement Complement activation contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 severity COVID-19 therapeutics cytotoxicity Efficacy and safety elicit elicited Fc receptor Fc receptors Fc-mediated functions feature function hospitalized COVID-19 patient hospitalized COVID-19 patients hyperinflammation immune functions induce Inflammation Innate innate immune function neutralization pathogen pathogen clearance pathophysiological mechanism pathophysiological mechanisms phagocytosis SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines severity specific antibody systemic inflammation tested understanding vaccine-induced antibody [DOI] 10.1128/mBio.00281-21 PMC 바로가기 [Article Type] Observation
Neural network analysis of clinical variables predicts escalated care in COVID-19 patients: a retrospective studyBioinformatics Published on 2021-04-192022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Adding admitted to ICU Algorithm Analysis AUC Blood C-reactive protein can be used Care cell count characteristic clinical variable collected Comorbidities coronavirus COVID-19 COVID-19 patient creatinine D-dimer determine downstream healthcare help Hospitalized hospitalized COVID-19 patient ICU ICU admission ICU care identify intensive care Laboratory Laboratory tests lactate dehydrogenase Lymphocyte count machine learning network analysis Neural Patient physician Pneumonia predict prediction Predictive Predictive model predictor resources Retrospective study ROC SARS-CoV-2 test dataset variable vital sign was performed was used [DOI] 10.7717/peerj.11205 PMC 바로가기 [Article Type] Bioinformatics
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine stormsUNC13D 및 AP3B1의 생식선 변이체는 심각한 사이토카인 폭풍을 경험하는 COVID-19 환자에서 풍부합니다Brief Communication Published on 2021-04-192022-09-10 Journal: European Journal of Human Genetics [Category] MERS, 변종, 유전자 메커니즘, [키워드] analyzed AP3B1 association characterized conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytokine storms DHX58 Factor Genes germline help hemophagocytic lymphohistiocytosis HLH hospitalized COVID-19 patient host inflammatory response host inflammatory responses Hyperinflammatory Immunogenetics individual Infection management outcome outcomes PID Primary Immunodeficiency RNF168 significantly susceptibility UNC13D variant variants viral infection whole-exome sequencing [DOI] 10.1038/s41431-021-00886-x PMC 바로가기 [Article Type] Brief Communication
Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysisArticle Published on 2021-04-132022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] 105 patient Absolute lymphocyte count absolute neutrophil count ALC ANC association C-reactive protein characterized Clinical course Clinical outcome Clustering Clustering analysis Clusters Cohort COVID-19 COVID-19 patient CRP CRP level CRP levels determine died elevated hospitalized COVID-19 patient hyper-inflammatory immune response hyper-inflammatory response identify immune response IMPROVE independent Inflammation inflammatory immune response Inflammatory response lymphopenia outcome oxygen support Patient patients pattern required Respiratory tract diseases retrieved severe disease supplementary oxygen three groups validation cohort was used were assessed [DOI] 10.1038/s41598-021-87668-z PMC 바로가기 [Article Type] Article
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patientsArticle Published on 2021-04-132022-10-04 Journal: Cell Discovery [Category] 변종, 진단, 치료기술, [키워드] accelerate acute respiratory syndrome affected anal swab Antimicrobial therapy assays Bacterial bioinformatics Burkholderia caused characterization China Clinical outcome Cohort collected Combination complex coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Culture death demonstrated detection diagnostic disease deterioration disease severity expression Gene expression profiling global pandemic Guangdong Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients human respiratory virus ICU admission IMPROVE Infection Laboratory microbial microbial taxa Mycoplasma nasal pathogenic Patient patients predominant Prevent respiratory specimen respiratory tract rhinovirus RNA SARS-CoV-2 severe cases severely ill patient severely ill patients specimen Spread sputum Staphylococcus epidermidis throat swab tissue Total treatment regimen ultra-deep metatranscriptomic sequencing virulence gene was performed [DOI] 10.1038/s41421-021-00257-2 PMC 바로가기 [Article Type] Article
Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial입원한 COVID-19 환자의 치료에서 우수한 코르티코스테로이드인 Methylprednisolone 또는 dexamethasone: 삼중 맹검 무작위 대조 시험Research Article Published on 2021-04-102022-07-28 Journal: BMC Infectious Diseases [Category] 임상, [키워드] Admission clinical status conducted control group control groups coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 COVID-19 patients death demonstrated Dexamethasone dose Effectiveness enrolled group Hospital stay Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxic Intervention intervention group Iran measure Methylprednisolone no significant difference no significant differences on admission Ordinal Scale outbreak Patient Randomized controlled trial Randomly receive Registered remained Result significant difference significantly significantly lower Treatment treatment of COVID-19 Trial Trial registration two group two groups uninfected Vaccine ventilator were assessed WHO ordinal scale PMC 바로가기 [Article Type] Research Article
Prognostic value of thrombin generation parameters in hospitalized COVID-19 patientsArticle Published on 2021-04-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 진단, [키워드] adverse event association biochemical parameter cardiovascular diseases cell lysis Characteristics characterized clinical Coagulation correlated COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer death evaluate event Fibrinogen levels had more haematological diseases healthy controls healthy subject Hemostasis hospitalized COVID-19 patient hospitalized patient hypercoagulable IL-6 in-hospital mortality increase increase in indicated Infectious diseases Inflammation Inflammatory LDH marker mechanism Occurrence parameter Pneumonia positively correlated predict Prognosis Prognostic value Respiratory tract diseases risk ROC Curve SARS-COV-2 infection severe disease thrombin thromboembolic risk thrombosis tissue triggered variable Vascular were assessed [DOI] 10.1038/s41598-021-85906-y PMC 바로가기 [Article Type] Article