Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated SignalingResearch Article Published on 2012-02-012022-10-06 Journal: PLoS ONE [Category] 진단, [키워드] Activation acute respiratory syndrome Antiviral block catalytic catalytically active Cell cells complex complexes contributing to coronavirus CoV Defense disrupting Disruption domain Endoplasmic reticulum evade expressing expression form found HCoV-NL63 Host IFN IKKε inactive Infected inhibit Innate innate immune innate immune response interferon MAVS mechanism membrane mutant NL63 nuclear translocation Papain-like protease PLP promoters Protein reduced regulate required response RIG-I SARS-CoV Signaling signaling molecule subsequent TBK1 wild type [DOI] 10.1371/journal.pone.0030802 PMC 바로가기 [Article Type] Research Article
Human Influenza Is More Effective than Avian Influenza at Antiviral Suppression in Airway CellsArticle Published on 2011-06-122023-05-31 Journal: American Journal of Respiratory Cell and Molecular [Category] 신종인플루엔자, 조류인플루엔자, [키워드] Antiviral IFN Influenza innate immune response [DOI] 10.1165/rcmb.2010-0157OC PMC 바로가기 [Article Type] Article
PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling PathwayResearch Article Published on 2011-02-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation acute respiratory syndrome assays catalytic domain cells cellular complex conserved coronavirus cytoplasm deubiquitinase domain dose-dependent manner DUB ENCODE Evidence experiment finding identification IFN IFN signaling IFN signaling pathway IFN transcription IFN-β in vitro inactivated inactive Infection inhibit inhibited innate immune system IRF3 MHV-A59 mouse mouse hepatitis virus nonstructural protein 3 Nsp3 nuclear translocation overexpression Papain-like protease phosphorylate PLP2 Prevent principal Proteins receptor reduced Regulatory Replication reporter shown Spread supported target TBK1 TNF TRAF3 Treatment Type type I interferon upstream [DOI] 10.1371/journal.pone.0017192 PMC 바로가기 [Article Type] Research Article
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article
Human immunopathogenesis of severe acute respiratory syndrome (SARS)Article Published on 2007-03-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Adaptive immune response cellular chemokine Clinical course Complete complex cytokine dysregulated hallmark Host host immune system host immunity host response Human human host hypercytokinemia IFN Immunity immunological Immunopathogenesis immunopathology Impact imperative Infected infectious Inflammatory response Injury Innate immunity interferon mechanism Microarray molecular morbidity Progressive Protective Research response resulting SARS SARS Coronavirus SARS CoV SARS patients severe pathology severe SARS suggested systematic analysis type I [DOI] 10.1016/j.virusres.2007.02.014 PMC 바로가기 [Article Type] Article
SARS: Systematic Review of Treatment EffectsResearch Article Published on 2006-09-122022-10-29 Journal: PLoS Medicine [Category] Coronavirus, [키워드] 2003 active against acute respiratory distress acute respiratory syndrome adverse effect affected antiviral drug ARDS Author be applied Blood carried caused CENTRAL China clinical clinical trial clinician conducted Controlled convalescent plasma Corticosteroids cough criteria Culture database death death rate determine disease dosage drug Effect effective Effectiveness Evidence example Fever finding found group had no Health care help helping HIV/AIDS identify IFN IFN type I immune system immunoglobulins In vitro studies in vitro study include inclusion criteria Inconclusive Inflammation information Intravenous immunoglobulin Laboratory life-threatening Lungs MedlinePlus MONITOR NO occurred outbreak Outbreaks Patient patients patients with SARS Pneumonia Potential treatment Protein protocol real time recommendation reduce reduced reported Research researcher review ribavirin Ritonavir SARS patients SARS-CoV SARS-infected patient SARS-infected patients searched severe sneeze Source specific symptom steroid Steroids Symptom syndrome systematic review the WHO tissue treat Treatment Trial Type I IFN type I interferon viral disease virus viruses Web while WHO Wikipedia World Health Organization [DOI] 10.1371/journal.pmed.0030343 PMC 바로가기 [Article Type] Research Article
Cytokine regulation in SARS coronavirus infection compared to other respiratory virus infections †Research Article Published on 2006-02-152022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] acute respiratory syndrome Caco2 cell compared contribute cytokine Cytokine dysregulation cytokine profile cytokine signaling dysregulation human parainfluenza virus IFN IL‐6 IL‐6 immunopathology Inc induction Infection Inflammation Inflammatory cytokine Inflammatory response influenza A virus mechanism other respiratory virus Pathogenesis RANTES receptor Regulation Replication respiratory syncytial virus Respiratory virus infection RSV SARS Coronavirus SARS‐CoV significantly lower SOCS3 suggested suppressed TLR upregulated [DOI] 10.1002/jmv.20556 PMC 바로가기 [Article Type] Research Article
Lowered yields of virus-induced interferon production in leukocyte cultures and risk of recurrent respiratory infections in childrenArticle Published on 1999-11-292022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] Adenovirus age Blood Child children coronavirus correlation Culture cultures defined enrolled entire cohort Finnish follow-up period Genetic greater group highest IFN IFN response interferon leukocyte not differ objective otitis otitis media produced respiratory infection respiratory infections Result rhinovirus risk selected statistically significant difference stimulated upper respiratory infection variations virus viruses was measured [DOI] 10.1016/S1386-6532(99)00056-6 PMC 바로가기 [Article Type] Article