natural infection – Page 31 – Communicable Diseases Research

Immunogenicity of Multiple Doses of pDNA Vaccines against SARS-CoV-2

Article

Published on 2021-01-062022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

Characterization of hepatitis E virus natural infection in farmed rabbits

Article

Published on 2021-01-012023-06-10
Journal: Journal of viral hepatitis [Category] E형 간염,

[키워드] hepatitis E virus natural infection
[DOI] 10.1111/jvh.13387

Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines

Review

Published on 2020-12-302022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection

무료 SARS-CoV-2 스파이크 단백질 S1 입자는 COVID-19 감염의 병인에서 역할을 할 수 있습니다

Hypothesis

Published on 2020-12-302022-09-01
Journal: Biochemistry. Biokhimiia [Category] SARS, 변종, 진단,

[키워드] accompanied ACE ACE2 angiotensin angiotensin (1-7) Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 association caused Cell cell surface circulation cleavage site COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis D614G D614G mutation decrease disease downregulate downregulated Effect expression fraction Free furin furin protease higher infectivity Hypothesis Imbalance in vivo infected cell infected cells Infection Inflammation investigated lack lead less lung Lungs membrane-bound murine model mutant natural infection Particle Pathogenesis pathogenesis of COVID-19 Prevalence Protein pulmonary damage receptor-binding domains Recombinant spike protein Renin renin-angiotensin system reported role S protein S1 and S2 S1 subunit S1 subunit shedding SARS-CoV virus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 strain separation severity shown spike Spike protein subunits the cell the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 thrombosis trimer unlikely Viral Viral load virion virions wild type
[DOI] 10.1134/S0006297921030032 PMC 바로가기 [Article Type] Hypothesis

Biochemical and antigenic characterization of the structural proteins and their post-translational modifications in purified SARS-CoV-2 virions of an inactivated vaccine candidate

Original Article

Published on 2020-12-142022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

[키워드] Analysis anti-SARS-CoV-2 vaccines Antibody Response antibody response against antigenic antigenicity Antisera caused cleavage cleaved clinical trial convalescent convalescent serum COVID-19 pandemic demonstrated elicit facilitate FIVE form forms full-length S glycoprotein glycosylated immunization immunized immunogenic inactivated Inactivated vaccine membrane Modification modifications natural infection Neutralizing antibodies pathogenesis of SARS-CoV-2 post-translational modification protease Protein purified Quality control S glycoprotein S protein S1 and S2 S1/S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 virion sera shown stimulated structural protein structural proteins subunit subunits the vaccine vaccination Vaccine vaccine candidate Vero virion virions
[DOI] 10.1080/22221751.2020.1855945 PMC 바로가기 [Article Type] Original Article

Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh

방글라데시에서 경증 또는 무증상 환자의 코로나19 감염 후 항체 반응

Article

Published on 2020-12-012022-09-12
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses Asymptomatic asymptomatic infection coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 infection declined develop Diagnosis enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay healthy control healthy controls herd immunity IgA IgA response IgA responses IgG IgG response IgG responses IgM immune response immune responses Immunity Impact individual individuals infected individual infected with SARS-CoV-2 Infection less Mild mildly symptomatic patient mildly symptomatic patients modeling natural infection objective Patient peaked positive Receptor-binding domain remained respiratory respond Result RT-PCR SARS-CoV-2 Seroconversion seroconverted serological response serum IgG severe acute respiratory syndrome Coronavirus significantly symptomatic symptomatic individual symptomatic individuals the receptor-binding domain vaccination virus viruses
[DOI] 10.1016/j.ijid.2020.09.1484 PMC 바로가기 [Article Type] Article

[Immunity against SARS-CoV-2: walking to the vaccination]

[SARS-CoV-2에 대한 면역: 예방 접종을 위해 도보]

Review

Published on 2020-12-012022-09-11
Journal: Revista española de quimioterapia : publicación [Category] MERS, SARS, 임상, 진단, 치료법,

Severe acute respiratory syndrome coronavirus‐2 natural animal reservoirs and experimental models: systematic review

중증급성호흡기증후군 코로나바이러스-2 천연동물 저장소 및 실험모형: 체계적 고찰

Review

Published on 2020-11-182022-09-10
Journal: Reviews in Medical Virology [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome addition age Animal host animal hosts animal model animal models animal reservoirs animals antiviral agent Antiviral agents antiviral drug antiviral drugs article bats clinical symptom Clinical symptoms conducted COVID‐19 database Direct disease transmission Diseases dose Drug discovery evaluate Evidence ferret ferrets hamster hamsters human infection Infection initial inoculation interactions involved mice mink natural infection outbreak pangolins PIGS poultry Research researcher reservoir respiratory Rousettus route SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Science Science Direct searched susceptible systematic review therapeutic agent therapeutic agents Therapeutics Transmission Vaccine Vaccine development Vaccines Viral viral replication virus virus replication Web of Science
[DOI] 10.1002/rmv.2196 PMC 바로가기 [Article Type] Review

Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years

Research Article

Published on 2020-11-132022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS,

[키워드] active infection acute respiratory syndrome adaptive Adaptive immune response assumption coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 cases Critical cross-reactions disease Efficacy elicited Epidemics epidemiological estimate feature highlight Human immune immune response Immunity immunological IMPROVE Infection Interaction knowledge less life history magnitude modeling natural infection Nonpharmaceutical interventions outcome pandemic Protective protective immunity provoke provoking risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Science severe cases sustained trajectory translation vaccination Vaccine Vaccines Variation variety
[DOI] 10.1126/science.abd7343 PMC 바로가기 [Article Type] Research Article

Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression

Research Article

Published on 2020-11-122022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

[키워드] addition animal model antiviral response caused cell population changes in chemokine collected contribute COVID-19 COVID-19 progression Critical cytokine days post infection dissemination Epidemic GM-CSF IL-10 IL-15 IL-1β IL-4 IL-6 increases in Infection infection rate interstitial pneumonia Local local immune response Lower respiratory tract lung lung tissue lymph nodes MCP-1/CCL2 nasal natural infection observation parameter Pathogenesis pathogenesis of SARS-CoV-2 pathologic process pathological analysis PBMCs progression respiratory tract resulting rhesus SARS-CoV-2 SARS-COV-2 infection severe pneumonia Stool suggested suppressed T cell T cell response T cell subset the SARS-CoV-2 virus Treatment Treg understanding Vaccine Vaccine development Viral RNA virus
[DOI] 10.1371/journal.ppat.1008949 PMC 바로가기 [Article Type] Research Article