Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents무증상 또는 경증의 증상이 있는 SARS-CoV-2 감염은 소아 및 청소년에서 지속적인 중화 항체 반응을 유발합니다Research Article Published on 2021-09-082022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] acute infection Adaptive immunity All participants Antibody Response Antibody responses Asymptomatic children comparable contribute detectable elicit evaluated generate humoral immune response humoral immune responses IgA IgG IgM immune response immune responses immunology Infectious disease Mild Neutralizing activity Neutralizing antibody response Participants populations question Reinfection robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection sera Spread strength symptomatic infection symptomatic SARS-CoV-2 infection virus-neutralizing [DOI] 10.1172/jci.insight.150909 PMC 바로가기 [Article Type] Research Article
Neutralizing antibodies for the prevention and treatment of COVID-19코로나19 예방 및 치료를 위한 중화항체Review Published on 2021-09-082022-09-11 Journal: Cellular and Molecular Immunology [Category] SARS, 변종, 비임상, 신약개발, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 antibody binding binding affinity cellular receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 effective Efficiency focus followed by host cell Immunotherapy IMPROVE infection process information initiate membrane fusion monoclonal antibodies N-terminal domain NAb NAbs neutralization Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody Protein provide provided RBD Receptor-binding domain respiratory S protein S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S protein SARS-CoV-2 strains SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 therapeutic target Treatment treatment of COVID-19 Viral viral infection viral spike virus entry [DOI] 10.1038/s41423-021-00752-2 PMC 바로가기 [Article Type] Review
The rapid adaptation of SARS-CoV-2-rise of the variants: transmission and resistance변종의 SARS-CoV-2-rise의 신속한 적응: 전송 및 저항Review Published on 2021-09-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cell entry cleaved convalescent sera coronavirus COVID-19 dominant Efficacy Genetic variant globe interact monoclonal monoclonal antibodies monoclonal antibody mutated Mutation neutralization Neutralizing activity occur Protein reduced reported SARS-CoV-2 Serine serine protease serine protease TMPRSS2 severe acute respiratory syndrome Coronavirus significantly strain therapy TMPRSS2 Transmissibility Transmission Vaccine vaccine efficacy variant variants [DOI] 10.1007/s12275-021-1348-5 PMC 바로가기 [Article Type] Review
The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serumSARS-CoV-2 회복기 혈청의 중화 활성 및 RBD 결합에 대한 스파이크 N501Y 돌연변이의 영향Article Published on 2021-09-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] 95% CI Amino acid amino acids ANOVA Anti-RBD IgG Anti-S1 antibody Antibody binding assays B.1.1.7 B.1.351 binding binding domain clinician collected convalescent sera convalescent serum COVID-19 COVID-19 patient determine enzyme immunoassay evaluated geometric geometric mean geometric mean titer GMT Hong Kong IgG isolates K417N Lineage mean difference Michael microneutralization N501Y N501Y mutation neutralization Neutralizing activity neutralizing antibody Neutralizing antibody Spike protein receptor binding domain NSP2 one-way ANOVA Patient positive Protein RBD RBD binding Receptor binding Receptor binding domain recovered COVID-19 patient reduced Richard SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 lineage SARS-CoV-2 N501Y variant B.1.1.7 sensitivity sera serum service significantly spike Spike protein Spike receptor binding domain Spread statistically susceptibility symptom onset tested variant variants virus virus variant virus variants viruses VoC VOC. was determined wild-type [DOI] 10.1016/j.ebiom.2021.103544 PMC 바로가기 [Article Type] Article
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies Research Published on 2021-08-312022-10-05 Journal: Nature [Category] SARS, 변종, 진단, [키워드] ACE2 angiotensin-converting enzyme 2 antibodies antibody Cell cells conserved DC-SIGN domain ENhance expressing identify Infection L-SIGN lectin mechanism membrane modulating neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody pathway receptor receptor binding motif receptors SARS-CoV-2 SARS-COV-2 infection SIGLEC1 the receptor-binding domain [DOI] 10.1038/s41586-021-03925-1 [Article Type] Research
Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2Immunology Published on 2021-08-302022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] A475V addition Against antibody Antibody neutralization authentic SARS-CoV-2 virus convalescent COVID-19 patients D614G demonstrated drug epitope exhibited functional mutant mutated mutation resistance NAb neutralization activity neutralization potency Neutralizing activity Neutralizing antibodies neutralizing antibody nine novel pseudovirus RBD binding RBD binding affinity recombined antibody reconstructed SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 neutralizing antibody screened Spike protein Spike proteins systemically therapeutic agent vaccine-induced immune response variant [DOI] 10.3389/fimmu.2021.715464 PMC 바로가기 [Article Type] Immunology
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York뉴욕에서 확인 후 SARS-CoV-2 B.1.526의 출현 및 확장Article Published on 2021-08-242022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody antibody resistance antigenic B.1.1.7 B.1.1.7 lineage B.1.526 Clinical use contribute contributed dominance E484K Efficacy emergence Extensive globe growth individual Iota less Lineage Microbiology monoclonal antibodies monoclonal antibody Mutation N501Y neutralization Neutralizing activity New York New York City other variant other variants plasma replaced reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant serum spike mutation Spike protein Spread spread of COVID-19 susceptible the SARS-CoV-2 the spike protein the United State therapeutic Transmission Transmission dynamics United States vaccinated individuals Vaccine variant variants Viral viral evolution Virology [DOI] 10.1038/s41586-021-03908-2 PMC 바로가기 [Article Type] Article
Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report회복기 COVID-19 혈장 슈퍼 기증자에서 고역가 바이러스 중화 항체의 장기 지속성 및 관련 치료 영향: 사례 보고서Case Reports Published on 2021-08-232022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Administered anti-S antibody Biosafety Level 3 Case report clinical setting convalescent correlated correlation COVID-19 criteria Donor enrolled expected FIVE Follow-up Hyperimmune plasma IgA IgA level IgA levels IgG and IgM Impact independent Microneutralization test National National Cancer Institute Neutralizing activity Neutralizing antibodies Neutralizing titer Patient patient with COVID-19 plasma RBD/ACE2-binding inhibition test report Rome SARS-CoV-2 SARS-CoV-2 patient serum severe COVID-19 symptoms steadily decreased the patient transfusion unit were measured [DOI] 10.3389/fimmu.2021.690322 PMC 바로가기 [Article Type] Case Reports
Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19Article Published on 2021-08-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] animal model antibody Antigen candidate candidate vaccine controls coronavirus 2 COVID-19 COVID-19 patients determine Escherichia coli expressed glycosylated glycosylation glycosylation site highlight Host immune response Hypothesis IgG antibody immunized immunogenic potential limit mice Neutralizing activity neutralizing antibody not carry Patient polyclonal antibody Potential Prokaryotic expression Protein protein region purified raise RBD Receptor binding domain recombinant Region Research residue respiratory S-RBD SARS-CoV-2 selected sera serum Spike protein strong immune response the Spike Vaccine viral glycosylation [DOI] 10.3390/vaccines9080928 PMC 바로가기 [Article Type] Article
Analysis of the molecular mechanism of SARS-CoV-2 antibodiesSARS-CoV-2 항체의 분자 메커니즘 분석Review Published on 2021-08-202022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibody antibody cocktail beta-coronavirus binding domain binding epitope caused Chinese death effective epitope Epitopes human cells include infect Infection mechanism molecular mechanism monoclonal antibodies monoclonal antibody neutralize Neutralizing activity NTD pandemic provide RBD Receptor binding domain receptor binding domain (RBD) Region reported Research respiratory Respiratory disease S protein S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 mutants Spike proteins TCM the antibody the S protein the SARS-CoV-2 the spike protein therapy Traditional Chinese medicine Treatment treatment strategy Vaccine vaccine therapy WHO [DOI] 10.1016/j.bbrc.2021.06.001 PMC 바로가기 [Article Type] Review