Growth, Antigenicity, and Immunogenicity of SARS-CoV-2 Spike Variants Revealed by a Live rVSV-SARS-CoV-2 VirusMedicine Published on 2022-01-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] anti-viral drug antibodies antibody antigenicity Beta comparable convalescent COVID-19 patients coronavirus Efficacy elicit G protein Growth Curve hamsters Health human ACE2 immunogenicity in vitro Infectivity introduced mice mutant mutant virus Mutation neutralized Neutralizing antibody response neutralizing monoclonal antibody pandemic RBD recurrent mutation resulting Revealed RNA virus SARS-CoV-2 selected sera single dose spike spike variant the receptor-binding domain therapeutic Vaccine Vaccines variant variants VSV wild-type wild-type virus [DOI] 10.3389/fmed.2021.793437 PMC 바로가기 [Article Type] Medicine
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variantResearch article Published on 2022-01-062022-10-05 Journal: Cell [Category] 변종, [키워드] Ad26.COV2.S vaccine addition BNT162b booster breadth COVID-19 cross-reactivity Delta dose exhibited highlight Humoral immunity individual induce infect Infectivity mRNA mRNA vaccine mRNA-1273 mRNA-based COVID-19 vaccine Mutation neutralization neutralization potency Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses neutralizing immunity omicron other variant pseudovirus recent recipient SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudoviruses SARS-CoV-2 variants sera spike Spike protein Surveillance tested the SARS-CoV-2 undetectable vaccination vaccinees variant variants wild type wild-type [DOI] 10.1016/j.cell.2021.12.033 [Article Type] Research article
Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion PeptideSARS-CoV-2 융합 펩티드에 대한 인간 및 고양이 코로나바이러스 교차 반응성 항체의 기능 분석Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] Against Alpha alpha- Analysis antibody Antigen being betacoronaviruses binding broadly neutralizing antibodies conserved coronavirus Coronavirus infection Coronaviruses COVID-19 patients cross-reactive antibody demonstrated disease elicited endemic human coronaviruses epitope exhibited Fc-mediated effector function Fc-mediated effector functions fusion fusion peptide Human human sera immunogenic Infection Kinetics N-terminal Neutralizing activity pepscan peptide Protective S2 subunit SARS-CoV-2 SARS-CoV-2 variants sera severity spike the SARS-CoV-2 therapeutic Viral viral spike [DOI] 10.3389/fimmu.2021.790415 PMC 바로가기 [Article Type] Immunology
Immune Maturation Effects on Viral Neutralization and Avidity of Hyperimmunized Equine Anti-SARS-CoV-2 SeraCommunication Published on 2022-01-022022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] analyzed anti-SARS-CoV-2 Antigen avidity biological activity country COVID-19 develop domain Effect hyperimmune hyperimmune equine hyperimmunization immune maturation immunization immunochemical increase in initial neutralize polyclonal producing SARS-COV-2 infection sera Spike protein the RBD the SARS-CoV-2 therapeutic Therapeutics viral neutralization [DOI] 10.3390/antib11010003 PMC 바로가기 [Article Type] Communication
Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopesSARS-CoV-2의 중화에는 구조적 수용체 결합 도메인 에피토프에 대한 항체가 필요합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antibody repertoire Antibody Response Antibody responses clinically conformational conformational epitopes coronavirus correlated COVID-19 Critical determinant determinants domain effective vaccine Effective vaccines epitope Epitopes exposure to humoral immune response IgG IgG antibodies IgG antibody Immunity immunization Immunoglobulin Immunoglobulin G increasingly induce likelihood Mild natural infection Neutralizing antibodies Patient peptide peptide epitope peptide epitopes peptides polyclonal polyclonal antibody Prevent Protective protective immunity RBD RBD binding RBD-specific IgG receptor Receptor-binding domain required respiratory SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody sera severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein sterilizing immunity suppression the receptor-binding domain the SARS-CoV-2 vaccination Vaccine Vaccines variant virus Virus neutralization virus variants virus-neutralizing [DOI] 10.1111/all.15066 PMC 바로가기 [Article Type] Article
Two novel SARS-CoV-2 surrogate virus neutralization assays are suitable for assessing successful immunization with mRNA-12732개의 새로운 SARS-CoV-2 대리 바이러스 중화 분석은 mRNA-1273을 사용한 성공적인 면역 평가에 적합합니다.Article Published on 2022-01-012022-09-12 Journal: Journal of virological methods [Category] SARS, 진단, [키워드] anti-S IgG biosafety classical COVID-19 effort Genscript Health care worker high correlation humoral immunization inactivated individual Laboratory Laboratory test mRNA-1273 Neutralization assay Neutralizing activity neutralizing SARS-CoV-2 antibody Patient SARS-CoV-2 SARS-CoV-2 vaccines second vaccination sensitivity sera specificity Spike-based vaccine spike-based vaccines Successful vaccination surrogate surrogate virus neutralization assay sVNT Switzerland Test the RBD time-consuming USA vaccination Vaccine Virus neutralization virus neutralization assay whole virus vaccines [DOI] 10.1016/j.jviromet.2021.114297 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Neutralizing Antibodies in White-Tailed Deer from Texas텍사스 흰꼬리사슴의 SARS-CoV-2 중화 항체Short Communications Published on 2022-01-012022-09-10 Journal: Vector Borne and Zoonotic Diseases [Category] SARS, 진단, 치료기술, [키워드] antibodies antibody collected conducted deer determine Evidence evidence of female highest Infection male neutralizing antibody New York pandemic plaque reduction neutralization positive reported SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sera serological evidence significantly tested Texas the United State United States virus white-tailed deer [DOI] 10.1089/vbz.2021.0094 PMC 바로가기 [Article Type] Short Communications
Nanoluciferase-based cell fusion assay for rapid and high-throughput assessment of SARS-CoV-2-neutralizing antibodies in patient samplesArticle Published on 2022-01-012022-11-15 Journal: Molecules [Category] SARS, 변종, 진단, [키워드] 384-well format ACE2 ACE2 receptor antibody applied approach assays automatization biosafety Cell Cell fusion cell lines classical COVID COVID-19 evaluate expressed gold standard Health HiBiT High-throughput host cells human Angiotensin-converting enzyme Immunity in vitro individual Interaction luciferase NanoBiT NanoLuc Neutralization assay Neutralizing antibodies neutralizing capacity Patient Prevent receptor reducing replication-competent virus risk Safe SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2-neutralizing antibody sera spike variants stability substrate syncytium utility vaccinated individuals variant variety viral entry viral neutralization viral spike viral spike protein virus neutralization assay [DOI] 10.1016/bs.mie.2022.07.015 PMC 바로가기
Low Serological Prevalence of SARS-CoV-2 Antibodies in Cancer Patients at a German University Oncology Center독일 대학 종양학 센터의 암 환자에서 SARS-CoV-2 항체의 낮은 혈청학적 유병률Article Published on 2022-01-012022-09-11 Journal: Oncology research and treatment [Category] MERS, SARS, 진단, 치료기술, [키워드] active cancer acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antibody testing Cancer cancer patient Cancer patients cancer type center Chemotherapy coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease-19 seroprevalence COVID-19 COVID-19 biobank diagnosed Diagnosis effort Elecsy Elecsys enrolled Epidemiology Europe faster German oncology center Germany hospital Immunity malignancy oncology palliative treatment Pancreatic cancer pandemic Patient patients Patients with cancer Prevalence prevalent preventive measure preventive measures respiratory risk of infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection sera serological Severe acute respiratory syndrome coronavirus type 2 single-center Support the patient Treatment university vaccination vaccination rates [DOI] 10.1159/000520572 PMC 바로가기 [Article Type] Article
In vitro data suggest that Indian delta variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion시험관 내 데이터에 따르면 SARS-CoV-2의 인도 델타 변이체 B.1.617은 수용체 친화성과 면역 회피 모두에 의해 중화를 피합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, [키워드] ACE2 affinity Anti-RBD IgG antibodies antibody B.1.351 B.1.617 binding binding affinity Binding assays BLI BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine cell receptor convalescent correlated COVID-19 convalescent donor COVID-19 convalescent donors delta variant display E484K ectodomain Effect ELISA glycoprotein higher affinity immune evasion Immunity immunization immunized Inhibition assays Interaction Interferometry L452R less main receptor mRNA vaccine mutant mutated Mutation natural infection neutralization occur P.1 Point mutation produced RBD RBD-ACE2 RBDs receptor Receptor-binding domain recognize reduced SARS-CoV-2 SARS-CoV-2 variant sera shown single mutant subject Substitution substitutions the binding affinity the RBD the receptor-binding domain the Spike Transmissibility vaccination Vaccine variant variants variants of concern Virus neutralization wild-type wild-type virus [DOI] 10.1111/all.15065 PMC 바로가기 [Article Type] Article