Viral Load of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Respiratory Aerosols Emitted by Patients With Coronavirus Disease 2019 (COVID-19) While Breathing, Talking, and Singing호흡하고, 말하고, 노래하는 동안 코로나바이러스 질병 2019(COVID-19) 환자가 방출하는 호흡기 에어로졸에서 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)의 바이러스 부하Article Published on 2022-05-302022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accounted acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol aerosol transmission Aerosols Airborne transmission Asymptomatic breath breathing coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine driving expiratory exposure to Isolating load Multiple N gene pandemic participant Participants Patient presymptomatic produced ranged respiratory respiratory aerosol respiratory aerosols RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA copies SARS-CoV-2 RNA copy SARS-CoV-2 transmission SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 singing superspreading event superspreading events talking Variation Viral load viral loads Viral RNA virus virus culture while [DOI] 10.1093/cid/ciab691 PMC 바로가기 [Article Type] Article
Accuracy of rapid point-of-care antigen-based diagnostics for SARS-CoV-2: An updated systematic review and meta-analysis with meta-regression analyzing influencing factorsSARS-CoV-2에 대한 신속한 현장 진단 항원 기반 진단의 정확성: 영향 요인을 분석하는 메타 회귀 분석을 통한 업데이트된 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-262022-09-11 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval Accuracy acute respiratory syndrome coronavirus Ag-RDT Ag-RDTs Analysis Antigen Asymptomatic Chain Reaction Comprehensive coronavirus 2 Ct-value Ct-values cycle threshold database decrease Descriptive analyses Descriptive analysis detect diagnostics driven by duration of symptom Effect estimate evaluate Factor false False negative heterogeneity high viral load highest in viral individual infected with SARS-CoV-2 information Meta-analysis meta-regression meta-regression models multivariable nasopharyngeal Patient peer-reviewed performed point-of-care polymerase chain polymerase chain reaction positive PROSPERO public health random-effect Random-effects meta-analysis Rapid diagnostic test RDTs Registered registration number respiratory reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 searched sensitivity Sensitivity and specificity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Standardization symptom onset symptom status symptomatic systematic review Testing the mean Viral load virus was used [DOI] 10.1371/journal.pmed.1004011 PMC 바로가기 [Article Type] Meta-Analysis
Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In VivoMolnupiravir 및 활성 형태인 EIDD-1931, 시험관 내 및 생체 내 엔테로바이러스 감염에 대한 강력한 항바이러스 활성을 나타냄Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] 치료제, [키워드] active form activity administration Analysis Antiviral antiviral drug approved aseptic meningitis children Concentration concentrations COVID-19 death disease drug candidate EIDD-1931 EIDD-2801 Encephalitis enterovirus expression foot form hand Health authority indicated Infant Infants Infection infections mechanism Meningitis mice molnupiravir myocarditis plasma drug potent progeny reduce reducing reported show significantly state Treatment treatment of COVID-19 United Kingdom various tissue various tissues Viral load Viral protein virus [DOI] 10.3390/v14061142 PMC 바로가기 [Article Type] Article
Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaquesResearch article Published on 2022-05-252022-10-05 Journal: iScience [Category] 비임상, [키워드] blunting cells clinical trials decrease explain FIVE Hospitalization hospitalized patient increases in Infection innate immune response intensity lung lung damage lung viral load Lungs mathematical modeling Molecular modeling nasal nasal passage nasal passages occur Pneumonia prevented raise reducing reduction in Remdesivir rhesus macaque rhesus macaques SARS- CoV-2 SARS-CoV-2 shedding relative therapy Viral load viral loads Virology [DOI] 10.1016/j.isci.2022.104448 [Article Type] Research article
Longer amplicons provide better sensitivity for electrochemical sensing of viral nucleic acid in water samples using PCB electrodes더 긴 앰플리콘은 PCB 전극을 사용하여 물 샘플에서 바이러스 핵산의 전기화학적 감지에 더 나은 감도를 제공합니다.Article Published on 2022-05-252022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] Amplicon amplicons COVID-19 pandemic demonstrated detect determine DNA DNA fragment effort Formula gel gold gold standard Interaction Methylene Methylene blue Modification offer PCR PCR product PCR products prominence purification salt SARS-CoV-2 sensitivity significantly Surveillance text Viral load viral nucleic acid water [DOI] 10.1038/s41598-022-12818-w PMC 바로가기 [Article Type] Article
Aptamer Sandwich Lateral Flow Assay (AptaFlow) for Antibody-Free SARS-CoV-2 Detection항체가 없는 SARS-CoV-2 검출을 위한 앱타머 샌드위치 측면 흐름 분석(AptaFlow)Article Published on 2022-05-242022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Antigen approach aptamer bind binding Concentration contagious COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines detect detection DNA ELISA Flow Health high affinity identify immunoassay infected individuals Lateral lateral flow limit N-terminal domain NTD Probability provide Sandwich SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus Spike protein the SARS-CoV-2 Transmission Viral Viral load viral spread virus [DOI] 10.1021/acs.analchem.2c00554 PMC 바로가기 [Article Type] Article
Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study최적의 약물 요법과 복합 약물 요법과 COVID-19 치료의 효능: 숙주 내 모델링 연구Article Published on 2022-05-192022-09-11 Journal: Acta biotheoretica [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered administration Arbidol average basic reproduction number Cell Combination combination therapies combination therapy Combined Comparative Comparative effectiveness study COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 pathogenesis death drug Drug interventions drugs Effectiveness Efficacy help include infected cells infection-related mortality Inflammatory mediators interferon Intervention life-threatening Lopinavir Lopinavir/ritonavir mathematical medical intervention modeling number of infected Optimal control problem Optimal drug Regimen physician reduce regimen Remdesivir Ritonavir significantly Stage susceptible cell Treatment treatment of COVID-19 Viral load were used [DOI] 10.1007/s10441-022-09440-8 PMC 바로가기 [Article Type] Article
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in miceClofoctol은 SARS-CoV-2 복제를 억제하고 쥐의 폐 병리를 감소시킵니다Article Published on 2022-05-192022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] antiviral activity Bacterial cells Clofoctol Compound compounds COVID-19 patients drug Drug repurposing exhibited exhibiting Gene Expression geographical areas human ACE2 receptor human lung IC50 identify Inflammatory inhibit investigated library Lung pathology mice peak concentration pharmacokinetic Pulmonary pathology reduce reduced Registered Regulatory Respiratory tract infections safety profile SARS-CoV-2 SARS-CoV-2 replication screened Support tested therapeutic Therapeutic treatment These data transgenic mice Treatment treatment of COVID-19 patients Viral load [DOI] 10.1371/journal.ppat.1010498 PMC 바로가기 [Article Type] Article
Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients중증 성인 COVID-19 환자의 SARS-CoV-2 RNA혈증, N-항원혈증 및 바이러스 특이 항체의 결합 운동 분석Article Published on 2022-05-182022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] adult COVID-19 patient analyses Analysis antibody Antibody detection antigenemia bloodstream CAST Cohort collected Combined component COVID-19 patient COVID-19 patients Critically ill decreasing detection rate dissemination examined Free help immunoassays immunochromatography inverse correlation kinetic analysis lateral flow median median age median time nucleocapsid onset of symptoms patients performed plasma RBD Receptor binding domain respiratory RNA RT-PCR assay SARS-CoV-2 SARS-CoV-2-RBD specific antibodies specimen symptoms onset upper respiratory tract Viral Viral load virus virus clearance virus-specific antibodies [DOI] 10.1038/s41598-022-12461-5 PMC 바로가기 [Article Type] Article
Use of sewage surveillance for COVID-19 to guide public health response: A case study in Hong Kong공중 보건 대응 지침을 위한 COVID-19에 대한 하수 감시 사용: 홍콩의 사례 연구Article Published on 2022-05-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agency allele Allele-specific RT-qPCR build building Chain Reaction Community sewage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 situation Delta delta variant develop example genome sequence Health help high viral load Hong Kong individual infected case infected cases infected with COVID-19 Local outbreak pandemic Patient polymerase chain polymerase chain reaction positive positive result Public public health Public health intervention Quantitative quantitative polymerase chain reaction RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus sewage Sewage surveillance specimen Surveillance Targeted upstream sampling. triggered upstream use case viral genome sequences Viral load viral signal [DOI] 10.1016/j.scitotenv.2022.153250 PMC 바로가기 [Article Type] Article