Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population멕시코 인구에서 발견되는 SARS-CoV-2 스파이크 단백질 및 자연 돌연변이에 대한 구조적 통찰력Article Published on 2021-02-252022-09-10 Journal: Scientific Reports [Category] MERS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Amino acid amino acids binding binding site Cepharanthine circulating Clinical effect Computational biology and bioinformatics coronavirus coronavirus disease Coronavirus disease 2019 D614G described Drug discovery Hydroxychloroquine hydroxychloroquine) inhibitor Lineage molecular molecular docking molecular dynamic simulations mutant Mutation nelfinavir pandemic Protein Protein binding respiratory responsible S protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus the S protein wild type [DOI] 10.1038/s41598-021-84053-8 PMC 바로가기 [Article Type] Article
Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hot Spots, Functional Cross Talk, and Regulatory Interactions in SARS-CoV-2Research Article Published on 2021-02-232022-10-29 Journal: mSystems [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected affecting Amino acid Analysis angiotensin-converting enzyme 2 Antiviral binding caused clade co-occurrence Combination Comparative Comparative genomics Complete condition conditions contributing to coronavirus coronavirus disease country COVID-19 CpG D614G effective FIVE full-length genome functional annotation Genome Genomics geographical region highlighting host cell host proteins host-pathogen interaction hypoxia inhibiting Interaction membrane Mutation mutational studies MYO5A MYO5B MYO5C network network analysis novel nucleocapsid ORF8 pandemic pathogenicity pathway patients Phylogenomics Phylogeny polymorphism predicted Protein protein stability Proteins provided rate of infection receptor reduction in Region SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 virus screened Severity of infection single nucleotide SNP Spike protein strain Strains structural biology suggested the United State The United States thrombotic TMPRSS2 translation Transmissibility Transmission Treatment Variation Viral protein ZAP [DOI] 10.1128/mSystems.00030-21 PMC 바로가기 [Article Type] Research Article
Genomic Epidemiology of SARS-CoV-2 in Madrid, Spain, during the First Wave of the Pandemic: Fast Spread and Early Dominance by D614G VariantsArticle Published on 2021-02-222022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome Analysis B.1 collected coronavirus coronavirus disease COVID-19 D614G D614G mutation dominance dominant epidemic wave European population Frequency Genome Genome sequences hospital independent International Lineage lockdown National phylodynamic protein sequence RT-PCR SARS-CoV-2 SARS-CoV-2 viral sequenced Spain Spanish suggested the Spike Transport Wave [DOI] 10.3390/microorganisms9020454 PMC 바로가기 [Article Type] Article
Global Evidence of Temperature Acclimation of COVID‐19 D614G LinageResearch Article Published on 2021-02-152022-10-31 Journal: Global Challenges [Category] COVID-19, [키워드] Affect average Case series clade clades Climate climate impact Cluster coefficient collected correlated correlation country COVID‐19 COVID‐19 Critical D614G D614G mutation evidence of Factor Factors Genome Hierarchical clustering analysis high temperature majority negative correlation pandemic Primary outcome proportion Research retrospective SARS‐CoV‐2 SARS‐CoV‐2 significant negative correlation temperature Tolerance USA virus virus spread [DOI] 10.1002/gch2.202000132 PMC 바로가기 [Article Type] Research Article
Phylogenomics reveals viral sources, transmission, and potential superinfection in early-stage COVID-19 patients in Ontario, CanadaPhylogenomics는 캐나다 온타리오주에서 초기 단계의 COVID-19 환자에서 바이러스 소스, 전염 및 잠재적 중복 감염을 밝혀냅니다.Article Published on 2021-02-122022-09-01 Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Analysis Canada carried Cohort Community complement Contact tracing D614G Diseases early stages early-stage COVID-19 Effectiveness Epidemiology event Evolutionary biology filtered Genome Genome evolution GISAID database help heterozygous variant heterozygous variants IMPROVE Infectious disease International Ion limit MinION Missense Molecular epidemiology nasopharyngeal swabs Next-generation sequencing Pandemics pathogenicity Patient Phylogenetic analysis phylogenetics Phylogenomics platform Point mutation polymorphic site positive Public health intervention reveal SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequenced Sequencing Spike protein Spread Surveillance Swab synonymous variant the SARS-CoV-2 the spike protein Transmission Travel Viral viral genomes viral infection viral strain [DOI] 10.1038/s41598-021-83355-1 PMC 바로가기 [Article Type] Article
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell typesSpike D614G 돌연변이는 여러 인간 세포 유형의 SARS-CoV-2 감염을 증가시킵니다Research Article Published on 2021-02-112022-09-10 Journal: eLife [Category] MERS, 변종, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 receptor binding Caco-2 Calu Calu-3 cell Cell coronavirus COVID-19 D614G D614G mutation D614G variant effective epithelial cells expressing fold functional G614 variant genetics Huh7.5 Human human cell human cell lines human cells human lung human lung epithelial cells increase Lentiviral particle lentiviral particles Linkage disequilibrium mechanism Mutation ORF1b overexpressing Point mutation Population genetics Prevalence Protein proteolytic cleavage pseudotyped ranged SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus site-directed mutagenesis spike Spike protein surpassed the SARS-CoV-2 virus the Spike transducing variant variants virus wild-type [DOI] 10.7554/eLife.65365 PMC 바로가기 [Article Type] Research Article
Coding-Complete Genome Sequences of NITMA1086 and NITMA1139, Two SARS-CoV-2 Isolates from Belagavi District, Karnataka State, India, Harboring the D614G MutationGenome Sequences Published on 2021-02-112022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome Analysis coronavirus coronavirus disease D614G D614G substitution District genome sequence India isolate isolates nasopharyngeal swabs RNA SARS-CoV-2 sequence state [DOI] 10.1128/MRA.00016-21 PMC 바로가기 [Article Type] Genome Sequences
Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus)SARS-CoV-2(COVID-19 바이러스)의 게놈 돌연변이 및 단백질 2차 구조 및 용매 접근성의 변화Article Published on 2021-02-102022-09-10 Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis caused changes changes in coding gene coding genes coding region coding regions coronavirus COVID-19 pandemic COVID-19 virus D614G Data mining dataset deep learning Evolution facilitate genomic genomic mutation genomic mutations highly pathogenic Intervention Mutation mutation D614G ORF10 ORF6 ORF7a ORF7b pandemic Point mutation point mutations predicted prediction Protein researchers respiratory respond SARS-CoV-2 secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 solvent Spike protein Spread tracing Transmission unlikely Vaccine Viral viral genome sequences virus virus spike protein [DOI] 10.1038/s41598-021-83105-3 PMC 바로가기 [Article Type] Article
Molecular Epidemiology Surveillance of SARS-CoV-2: Mutations and Genetic Diversity One Year after EmergingArticle Published on 2021-02-092022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome analyzed association changes in Complete Continuous coronavirus D614G detect disease severity Diversity downloaded Europe Frequency GenBank genetic diversity Genome geographical region GISAID hotspot implicated IMPROVE increase in information molecular molecular surveillance MONITOR Mutation mutations natural selection Non-synonymous non-synonymous substitution Nsp12 NSP2 Oceania P323L pandemic Protein Region reported SARS-CoV-2 Seven spike Spread Substitution substitutions Surveillance the Spike Transmission dynamics variant virus Wuhan, China Year [DOI] 10.3390/pathogens10020184 PMC 바로가기 [Article Type] Article
SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinitySARS-CoV-2 D614G 스파이크 돌연변이는 향상된 ACE2 결합 친화력으로 진입 효율성을 높입니다.Article Published on 2021-02-082022-09-10 Journal: Nature Communications [Category] MERS, 변종, 진단, [키워드] ACE2 ACE2 receptor Affect analyses Antisera bind binding causative agent cell entry circulating cleaved COVID-19 pandemic D614G D614G mutation Efficiency ENhance exhibit higher affinity highest humans increase increases in lentivirus mutant mutants Mutation neutralization not affect occur predominant Protein reduce required SARS-CoV S SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 D614G spike mutation Spike protein supported Surveillance susceptibility TMPRSS2 Transmissibility Transmission variants Virus-host interactions viruses [DOI] 10.1038/s41467-021-21118-2 PMC 바로가기 [Article Type] Article