A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization다중 모드 지식 조화로부터 약물 용도 변경 후보의 합리적인 선택을 위한 방법Article Published on 2021-05-262022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] analyses approach can be used candidate Candidates Combination Computational models COVID-19 Data integration disease Drug repurposing experimental validation experiments flood hypotheses identify information involved knowledge nelfinavir pathophysiology Pathways predict raloxifene Remdesivir researcher SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic singular synergistic synergistic effect therapeutic compound Virtual drug screening [DOI] 10.1038/s41598-021-90296-2 PMC 바로가기 [Article Type] Article
Prediction of repurposed drugs for Coronaviruses using artificial intelligence and machine learningResearch Article Published on 2021-05-242022-10-04 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] Abstract ACE AI Alatrofloxacin Algorithm analyses antiviral drug antiviral drugs applicability approved artificial assist binding affinity caused Chemical descriptors complex computational method coronavirus coronavirus 2 Coronaviruses COVID-19 COVID-19 pandemic datasets deep develop domain drug candidate Drug repurposing DrugBank Epidemics feature filtered forest independent lack learning Leuprolide machine learning MERS Metergoline molecular docking network Neural Pearson’s correlation coefficient predict predicted molecule prediction Predictive model receptor Repository Repurposed drug Rescinnamine respiratory responsible robust SARS-CoV-2 selected support vector machine Telotristat ethyl the Coronaviridae the spike protein unique Verteporfin virus viruses were used [DOI] 10.1016/j.csbj.2021.05.037 PMC 바로가기 [Article Type] Research Article
Repurposing of antibiotics for clinical management of COVID-19: a narrative reviewCOVID-19의 임상 관리를 위한 항생제의 용도 변경: 내러티브 검토Review Published on 2021-05-212022-08-31 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] SARS, 신약개발, [키워드] activities Anti-inflammatory antibiotic Antibiotic resistance Antibiotics Antiviral antiviral activities antiviral properties approach Azithromycin Bacterial infection Bacterial infections cefuroxime ciprofloxacin clarithromycin Clinical management conducted COVID-19 COVID-19 infections COVID-19 pandemic doxycycline drug Drug discovery Drug repurposing drugs Impact include Infection investigated levofloxacin literature review Macrolide management mechanism moxifloxacin patients with COVID-19 pharmacological agent pharmacological agents Prevent Profiling repurposing Result SARS-CoV-2 SARS-COV-2 infection Teicoplanin tetracyclines use of antibiotics Web of Science with COVID-19 [DOI] 10.1186/s12941-021-00444-9 PMC 바로가기 [Article Type] Review
The journey of antimalarial drugs against SARS-CoV-2: Review articleReview article Published on 2021-05-192022-10-05 Journal: Informatics in Medicine Unlocked [Category] 신약개발, [키워드] acute respiratory syndrome affected Anti-malarial drugs antimalarial drug Antimalarial drugs Antiviral Chloroquine COIVD-19 combination therapy combinations coronavirus COVID-19 COVID-19 infection drug Drug repurposing Effect Efficacy exhibited faster global public health Hydroxychloroquine in vitro in vivo introduced investigated mechanism outbreak pandemic pandemic disease reducing repurposing review Safe SARS-CoV-2 Side effects Symptom tested the disease Treatment Trial [DOI] 10.1016/j.imu.2021.100604 [Article Type] Review article
Structure-based drug repurposing against COVID-19 and emerging infectious diseases: methods, resources and discoveriesArticle Published on 2021-05-172023-06-16 Journal: Briefings in Bioinformatics [Category] MERS, SARS, [키워드] COVID-19 Drug repurposing emerging diseases SARS-CoV-2 structure-based methods [DOI] 10.1093/bib/bbab113 PMC 바로가기
Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2중증급성호흡기증후군 코로나바이러스-2의 RNA 의존성 RNA 중합효소의 잠재적 억제제로서의 천연 식물 제품Research Article Published on 2021-05-132022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 치료제, [키워드] (RdRp acute respiratory syndrome coronavirus amarogentin amino acids ASP binding conformational change conserved coronavirus coronavirus 2 Drug repurposing exhibited free energy GLU glycosidic hydrogen hydrogen bonding inhibitor interacting residues Interaction Ligand molecular molecular docking molecular dynamics molecular dynamics simulations motif natural performed plant polar Principal component principal component analysis RdRP residue residues respiratory RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Small molecules stability supported Swertia thumb water [DOI] 10.1371/journal.pone.0251801 PMC 바로가기 [Article Type] Research Article
Repurposing Infectious Diseases Vaccines Against CancerReview Published on 2021-05-132023-08-30 Journal: Frontiers in Oncology [Category] E형 간염, [키워드] Drug repurposing Immunotherapy Infectious diseases oncology Preventive vaccines [DOI] 10.3389/fonc.2021.688755 PMC 바로가기 [Article Type] Review
Network medicine framework for identifying drug-repurposing opportunities for COVID-19COVID-19에 대한 약물 용도 변경 기회를 식별하기 위한 네트워크 의학 프레임워크435 Published on 2021-05-112022-08-31 Journal: Proceedings of the National Academy of Sciences of [Category] 신약개발, 치료제, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Algorithms approved approved drug approved drugs artificial intelligence best can not candidate capture clinical trial clinical trials clinically Compound Consensus coronavirus COVID-19 COVID-19 pandemic dataset de novo develop diffusion disease Diseases drug Drug repurposing drugs Effectiveness Efficacy evaluate expected human cell human cells identify infections Infectious diseases mechanism methodological Metrics network network medicine offer outcome pathogen Pathogens pathway Predictive Protein reduced respiratory SARS-CoV-2 screened screenings severe acute respiratory syndrome Coronavirus Significance Systems biology treat treatments for COVID-19 VeroE6 cells Viral viral infection [DOI] 10.1073/pnas.2025581118 PMC 바로가기 [Article Type] 435
Pharmacophore Modelling-Based Drug Repurposing Approaches for SARS-CoV-2 TherapeuticsChemistry Published on 2021-05-102022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome approved drugs average backbone binding binding pocket caused CDOCKER co-crystallized complex Compound compounds computational method coronavirus coronavirus disease COVID-19 COVID-19 therapeutics demonstrated deviation Discovery Studio docking drug Drug repurposing DrugBank DrugBank database effective Hydrogen bond inhibitor MDs Molecular docking study Molecular dynamics simulation Novel coronavirus outbreak PDB pharmacophore pharmacophore modelling Protein pursuit Remdesivir repurposing resulting S-adenosyl methionine SAM SARS-CoV-2 shown target the selected model Therapeutics Treatment was used [DOI] 10.3389/fchem.2021.636362 PMC 바로가기 [Article Type] Chemistry
Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral DiscoveryPharmacology Published on 2021-05-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral antivirals approved broad spectrum broad-spectrum antiviral category challenge COVID-19 defined described direct-acting drug Drug repurposing effective efficient emerging virus identify infections mechanism Prevent Progress public health repurposing Strategy threat treat Vaccine variety virus [DOI] 10.3389/fphar.2021.660710 PMC 바로가기 [Article Type] Pharmacology