Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization기존 면역의 맥락에서 SARS-CoV-2 스파이크 및 수용체 결합 도메인에 대한 체액 반응은 광범위한 사베코바이러스 중화를 부여합니다Article Published on 2022-08-042022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] approved B cell response Candidates clinically coronavirus elicited Epitopes evaluated Evaluating Humoral response IgG immune immune imprinting immune response immunization Infection naïve neutralization pre-existing immunity RBD reactivity Receptor binding domain receptor binding domain (RBD) regimen sarbecovirus Sarbecoviruses SARS-CoV-2 serum spike (S). spike glycoprotein the SARS-CoV-2 vaccination vaccine candidate [DOI] 10.3389/fimmu.2022.902260 PMC 바로가기 [Article Type] Article
Systemic autoimmune myopathies: a prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2전신 자가면역 근병증: SARS-CoV-2에 대한 비활성화된 바이러스 백신의 전향적 4상 대조 시험Clinical Trial Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 임상, 진단, [키워드] 95%CI adverse event age All participant anti-SARS-CoV-2 anti-SARS-CoV-2 vaccine Autoimmune baseline Comorbidity comparable control group Controlled trial CoronaVac COVID-19 CTRL disease disease status dose drug evaluate Frequency geometric mean titre GMT HIV/AIDS IgG immune response immunogenicity immunogenicity analysis Immunosuppression in both group inactivated interquartile range IQR less median Mild moderate Myopathy myositis Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody parameters participant Patient positive pre-vaccination protocol reduced RT-PCR S1/S2 Safe Safety SAM SARS-CoV-2 SARS-CoV-2 vaccine second dose Seroconversion serology Sex significantly lower systemic therapy Type Vaccine vaccine dose virus were excluded [DOI] 10.1093/rheumatology/keab773 PMC 바로가기 [Article Type] Clinical Trial
Effects of cardiopulmonary bypass on immunoglobulin G antibody titres after SARS-CoV2 vaccinationObservational Study Published on 2022-08-032022-10-05 Journal: Interactive cardiovascular and thoracic surgery [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome antibody Antibody titre BNT162b2 calculated Cardiopulmonary cardiopulmonary bypass cardiovascular disease coronavirus Coronavirus disease 2019 decrease disease Effect effective group IgG IgG antibody Immunoglobulin Infection investigated Moderna mRNA vaccine mRNA-1273 Patient Pfizer/BioNTech preoperative preserved prospective observational study required SARS-CoV2 severe acute respiratory syndrome coronavirus 2 significantly significantly lower surgical the receptor-binding domain titre U/mL vaccination vaccination schedule Vaccine was measured while [DOI] 10.1093/icvts/ivac123 PMC 바로가기 [Article Type] Observational Study
Auxiliary Screening COVID-19 by Serology혈청학에 의한 보조 스크리닝 COVID-19Meta-Analysis Published on 2022-08-022022-09-12 Journal: Frontiers in Public Health [Category] 진단, [키워드] 2019 novel coronavirus antibody Antibody detection article AUC auxiliary calculated Characteristics CNKI Cochrane Library COVID-19 COVID-19 diagnosis COVID-19 infection database detection rate diagnostic estimate IgG IgG and IgM IgM Improving likelihood ratio Meta-analysis Novel coronavirus nucleic acid Nucleic acid detection Odds ratio pandemic participant positive Receiver operator characteristic Science Screening screening method searched sensitivity serology serum serum specific antibody. specificity Support Web [DOI] 10.3389/fpubh.2022.819841 PMC 바로가기 [Article Type] Meta-Analysis
The durability of natural infection and vaccine-induced immunity against future infection by SARS-CoV-2SARS-CoV-2에 의한 미래 감염에 대한 자연 감염 및 백신 유도 면역의 내구성Comparative Study Published on 2022-08-022022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Ad26.COV2.S Analysis anti-S IgG antibody Antibody Response applied BNT162b2 booster vaccination Breakthrough infection ChAdOx1 conditions COVID-19 distribution elicited Endemic evaluated exceeded expected future infection IgG Immunity Immunoglobulin Infection knowledge likelihood median Messenger RNA Moderna mRNA mRNA-1273 natural infection Oxford-AstraZeneca pandemic parameter peak Pfizer-BioNTech public health Quantitative relative SARS-CoV-2 trajectory vaccination Vaccine Vaccine-induced immunity vaccine-mediated immunity Viral vector vaccine [DOI] 10.1073/pnas.2204336119 PMC 바로가기 [Article Type] Comparative Study
Three-month follow-up of durability of response to the third dose of the SARS-CoV-2 BNT162b2 vaccine in adults aged 60 years and older: a prospective cohort study60세 이상 성인에서 SARS-CoV-2 BNT162b2 백신 3차 접종에 대한 반응 지속성 3개월 추적: 전향적 코호트 연구Article Published on 2022-08-022022-09-12 Journal: BMJ Open [Category] Coronavirus, SARS, 진단, [키워드] Adverse adverse event Analysis anti-spike IgG level antibody Antibody titre arbitrary unit blood sample BNT162b2 BNT162b2 vaccine CFS clinical cohort study concerning correlated COVID-19 COVID-19 infection defined dose Epidemiology evaluate evaluated events Follow-up healthy IgG IgG level immunology IQR median median age multivariable analysis neutralising neutralising antibody Older participant Patient Prospective prospective cohort study remained reported scale secondary outcome seropositive significantly the SARS-CoV-2 titre titres Vaccine [DOI] 10.1136/bmjopen-2022-061584 PMC 바로가기 [Article Type] Article
Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes임신성 SARS-CoV-2 감염은 면역 및 영양막 유전자의 태반 발현과 관련이 있습니다Article Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence age Analysis antibody Birth CGB3 change contribute correlation CXCL10 DDX58 decreased expression during pregnancy Effect evaluate expression feature Features fetus Fisher Gene Expression Generation gestational age group groups Health histologic Histopathology IgG IgG antibody immune immune gene immune genes increased expression Infant Infants Linear regression linear regression models Maternal median molecular Mount Sinai Mount Sinai Health System NanoString nasal swab New York City no significant differences not differ offspring outcome participant Participants performed Placenta placental Placentas positive positive RT-PCR Pregnancy pregnant prospective cohort study PSG3 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-COV-2 infection serology test severe disease significant difference significant differences Spearman statistical analyses System term the SARS-CoV-2 TLR3 Transmission vertical transmission [DOI] 10.1016/j.placenta.2022.06.017 PMC 바로가기 [Article Type] Article
Simulated RBC antibody identification training panels created using SARS-CoV-2 kodecytes and immune plasmaSARS-CoV-2 kodecytes 및 면역 혈장을 사용하여 만든 시뮬레이션된 RBC 항체 식별 교육 패널Article Published on 2022-08-012022-09-12 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accuracy antibody antibody screening autoantibody can be used Cell competent develop Donor evaluated feasibility Frequency gel IgG IgG antibody immune Kodecyte maintain manual peptide plasma plasma sample platform positive Practical training Precision profile RBC Reactions required SARS-CoV-2 SARS-CoV-2 antibodies technology tested training unmodified cell warm [DOI] 10.1111/trf.17004 PMC 바로가기 [Article Type] Article
Subcutaneous immunoglobulins in chronic lymphocytic leukemia with secondary antibody deficiency. A monocentric experience during Covid-19 pandemics2차 항체 결핍을 동반한 만성 림프구성 백혈병에서 피하 면역글로불린. Covid-19 전염병 동안의 단일 중심적 경험Article Published on 2022-08-012022-09-12 Journal: Hematological oncology [Category] MERS, 진단, [키워드] administration age antibody appear baseline CD19 CD4/CD8 chronic lymphocytic leukemia CLL Comorbidities COVID 19 deficiency dosage dose Efficacy and safety eligibility event expenditures FIVE Frequency hypogammaglobinemia IgG IgG levels immune immune dysfunction Immunoglobulin immunoglobulin replacement therapy immunoglobulins increase infections initiated interstitial pneumonia leukemia lymphocyte Pandemics Patient Prophylaxis Quality of life receiving reduced risk of infections Safe secondary secondary antibody Subcutaneous subcutaneous immunoglobulins. subset therapy treated Treatment were recorded [DOI] 10.1002/hon.2966 PMC 바로가기 [Article Type] Article
Response to COVID-19 booster vaccinations in seronegative people with multiple sclerosis다발성 경화증이 있는 혈청 음성인의 COVID-19 추가 백신 접종에 대한 반응Article Published on 2022-08-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] anti-CD20 therapy association benefit Blood blood sample booster booster vaccination Cellular immune response COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstrated detectable Disease modifying therapies (DMTs) Evidence evidence of fingolimod humoral IgG IgG response immune response initial Laboratory Multiple multiple sclerosis Multiple sclerosis (MS) nucleocapsid antigen occurred participant Participants positive provided response SARS-CoV-2 spike protein Seroconversion seroconverted seronegative Spike protein T cell T cell response T-cell responses therapy treated vaccination Vaccine venous venous blood were measured Whole blood whole blood sample [DOI] 10.1016/j.msard.2022.103937 PMC 바로가기 [Article Type] Article