Comparative Genomics of the Sigatoka Disease Complex on Banana Suggests a Link between Parallel Evolutionary Changes in Pseudocercospora fijiensis and Pseudocercospora eumusae and Increased Virulence on the Banana Host바나나에 대한 Sigatoka 질병 복합체의 비교 유전체학은 Pseudocercospora fijiensis와 Pseudocercospora eumusae의 병렬 진화적 변화와 바나나 숙주의 독성 증가 사이의 연관성을 시사합니다Research Article Published on 2016-08-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adaptation Analysis analyzed assimilation banana biological process caused cell walls change changes in Comparative Comparative analysis Comparative genomics complementary complex conserved convergent evolution core gene Degradation disease disease control Diversity Dothideomycetes driven by effective effector proteins effectors Evolution evolutionary relationships facilitate facilitated fungi gene count gene families gene family Genes Genome genome architecture genome sequence genomes genomic genomic change Genomics higher efficiency Host host immune system identify increase in Increased indicated involved LTR management metabolic pathway metabolic pathways metabolism Modification pathogen pathogenic Pathogens plant cell profile proliferation Radiation remained sequenced Seven significant difference significant differences speciation Still supported understanding utilization virulence virulent [DOI] 10.1371/journal.pgen.1005904 PMC 바로가기 [Article Type] Research Article
Replication and shedding of MERS-CoV in Jamaican fruit bats ( Artibeus jamaicensis )Article Published on 2016-02-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] bat cells cellular change Clinical sign Dipeptidyl peptidase 4 disease DPP4 Evidence expression Gene Expression highlight histopathological Hypothesis Infection inoculated intestinal tract intrinsic investigated investigation Jamaican fruit bat lung Lungs maintain MERS-CoV Middle East moderate receptor replicate replicated reservoir respiratory syndrome coronavirus spike glycoprotein Virus shedding zoonotic [DOI] 10.1038/srep21878 PMC 바로가기 [Article Type] Article
Changes in the Swine Gut Microbiota in Response to Porcine Epidemic Diarrhea InfectionShort Communication Published on 2015-09-252022-10-31 Journal: Microbes and Environments [Category] Coronavirus, [키워드] 16S rRNA gene affected Bacterial cells change commensal bacteria complex Critical ecosystem epidemic diarrhea Faecalibacterium gastrointestinal tract group Gut gut microbiota Health Host identify Infection large intestine mammal microbiota MOST Next-generation sequencing PEDV Porcine epidemic diarrhea Prevotella response significant difference the healthy virus [DOI] 10.1264/jsme2.ME15046 PMC 바로가기 [Article Type] Short Communication
New Metrics for Evaluating Viral Respiratory PathogenesisResearch Article Published on 2015-06-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, 신종인플루엔자, [키워드] change changes in clinically connection evaluate Evaluating highlight human disease Infection marker Measures methodology Metrics mice New Pathogenesis Pulmonary function respiratory Respiratory function respiratory viral infections respiratory virus responses SARS-CoV severe systemic disease utility viral pathogenesis virus was used [DOI] 10.1371/journal.pone.0131451 PMC 바로가기 [Article Type] Research Article
Lipid lowering efficacy and safety of Ezetimibe combined with rosuvastatin compared with titrating rosuvastatin monotherapy in HIV-positive patientsHIV 양성 환자에서 로수바스타틴 적정 단독요법과 비교한 에제티미브와 로수바스타틴 병용요법의 지질강하 효능 및 안전성Research Published on 2015-06-192022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] addition AIP ALT Antiretroviral therapy API apoA1 ApoB Apolipoprotein B appear AST baseline characteristics C-reactive protein change Characteristics cholesterol clinical symptom Clinical symptoms clinical trial Combination combination treatment develop dose dyslipidemia dyslipidemias Efficacy Efficacy and safety eligible examined Ezetimibe group groups guideline HDL-C High-density lipoprotein High-density lipoprotein cholesterol High-sensitivity C-reactive protein HIV HIV-infected patient HIV-infected patients hsCRP improvement increase in LDL-C Lipid lipid profile Low-density lipoprotein Low-Density Lipoprotein cholesterol Mild minimum monotherapy myalgias not differ Open-label parameter Patient patients with HIV percentage plasma Primary outcome Randomized Result Rosuvastatin Safe Significant statin targets therapy Total cholesterol Transport treatment groups Trial Triglyceride two patients [DOI] 10.1186/s12944-015-0054-x PMC 바로가기 [Article Type] Research
Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013Research Article Published on 2015-03-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accumulated Amino acid amino acid substitution Analysis analyzed antigenic caused change Characteristics characterization characterized China Chinese Complete contagious death diarrhea Effectiveness epidemic diarrhea epitope Genetic Genetic variation Genome genome sequence hydrophilicity identify identity less Multiple Mutation N gene Neutralizing nucleotide ORF1a/b ORF3 outbreak PEDV proximal ranged S gene strain Strains structural protein unique Vaccine viral disease virus viruses vomiting watery [DOI] 10.1371/journal.pone.0120310 PMC 바로가기 [Article Type] Research Article
Proteome Profile of Swine Testicular Cells Infected with Porcine Transmissible Gastroenteritis CoronavirusResearch Article Published on 2014-10-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Alpha Analysis analyzed approach biological processes caspase-8 Cell cells cellular change complex conducted coronavirus determine developmental expression expression level Extracellular matrix gastroenteritis growth growth factor Heat shock help host cell immune system Infection Interaction knowledge maturation mechanism metabolite neurological system occur Ontology Pathogenesis post infection precursor profile Protein protein complex protein level Proteins proteomic provide quantitation Quantitative Signaling significant changes in Stage Stress Testicular TGEV TGF-β1 two-dimensional viral infection virus Virus-host interactions Western blot analysis [DOI] 10.1371/journal.pone.0110647 PMC 바로가기 [Article Type] Research Article
Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes폐렴구균 모자이크 유전자 내 베타-락탐 내성과 관련된 단일 뉴클레오티드 다형성의 포괄적인 식별Research Article Published on 2014-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] alterations Amino acid analysed antibiotic Antibiotic resistance Antibiotic treatment Antibiotics approach arise association Bacteria Beta-lactam beta-lactam antibiotics block blocks carried cause change children clinical setting collected Comprehensive description determinant determinants Diseases distribution DNA fragment explain Frequency Genetic genetic association genetic determinant genetic determinants Genome Genome sequencing Genome-wide association study genomes Haplotype identification identify INDEL indels independent dataset independent datasets introduced isolate isolates large sample leads lineages loci mechanism Meningitis morbidity morbidity and mortality more difficult mosaic Mutation nasopharyngeal non-susceptibility nucleotide organism performed pneumococcal Pneumonia pneumoniae populations predict Previous studies previous study raise Recombination reported resistance responsible sensitivity sequence single nucleotide Single nucleotide polymorphism single nucleotide polymorphisms SNPs Spread strain Strains Streptococcus pneumoniae susceptible Traditional Treatment understanding USA variant variants while [DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
How Change of Public Transportation Usage Reveals Fear of the SARS Virus in a CityResearch Article Published on 2014-03-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 2003 SARS acute respiratory syndrome change Chinese New Year city Epidemic fear Impact outbreak Public reported risk SARS virus School Taipei Taiwan Typhoon Nari Usage [DOI] 10.1371/journal.pone.0089405 PMC 바로가기 [Article Type] Research Article