In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression AnalysisPharmacology Published on 2020-09-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ADORA2A ADRB2 alleviation Analysis Anti-inflammatory antioxidant approach Astragaloside IV Bioinformatic Bioinformatics analysis caused chemokine contribute COVID-19 COVID-19 patients cytokine cytokine storms dataset DEGs differentially expressed gene down-regulated genes drug candidate GBP1 Gene Expression Omnibus Genes GEO GO term GSE147507 hyper-inflammation hyperinflammation IL1B IL6 Inflammation KEGG KEGG pathway Kyoto MLNR MMP13 network network pharmacological network pharmacology NFKBIA NLRP3 Ontology overlap overlapping pathway pathway enrichment performed pharmacological mechanism Pharmacology Potential prediction PTAFR Result SARS-CoV-2 screened System target TNF Treatment TRIM21 up-regulated [DOI] 10.3389/fphar.2020.556984 PMC 바로가기 [Article Type] Pharmacology
SARS-CoV-2 and coagulation disorders in different organsReview Article Published on 2020-09-152023-07-02 Journal: Life sciences [Category] SARS, [키워드] Coagulation complement system COVID-19 Disseminated intravascular coagulation hypercoagulability Inflammation SARS-CoV-2 Thromboembolism [DOI] 10.1016/j.lfs.2020.118431 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?Hypothesis Published on 2020-09-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome airway angiotensin-converting enzyme 2 approved bind Cell clinical manifestations Complication contributing to coronavirus disease Coronavirus-2 COVID-19 fingolimod FTY720 function help host–virus interaction implicated in some individuals induce infect Inflammation limit Loss of Smell lung majority mechanisms Mild modulation morbidity and mortality multiple sclerosis nasal nervous nervous system Neurological symptoms Olfactory epithelium organs overcome Pathogenesis patients pleiotropic receptor receptors regulate replicate responsible role SARS-CoV-2 severe pulmonary disease Signaling sphingosine 1-phosphate sphingosine 1-phosphate receptors Spread survival tested therapeutic strategy tissues Treatment viral infection virus virus propagation [DOI] 10.3390/ijms21186773 PMC 바로가기 [Article Type] Hypothesis
Utility of COVID-19 Screening in Cancer PatientsArticle Published on 2020-09-142023-06-19 Journal: Cancer cell [Category] Fulltext, SARS, [키워드] aging bats inflammaging Inflammation Longevity [DOI] 10.1016/j.ccell.2020.07.009 PMC 바로가기
Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)Article Published on 2020-09-142024-09-04 Journal: International journal of oncology [Category] 대상포진, [키워드] Cancer Inflammation Taurine taurine haloamines taurine upregulated gene 1 ncRNA [DOI] 10.3892/ijo.2020.5100 PMC 바로가기 [Article Type] Article
Caspase-8 mediates inflammation and disease in rodent malaria카스파제-8은 설치류 말라리아에서 염증과 질병을 매개한다.Article Published on 2020-09-142024-08-11 Journal: Nature Communications [Category] 말라리아, [키워드] Infectious diseases Inflammation malaria Parasite host response [DOI] 10.1038/s41467-020-18295-x PMC 바로가기 [Article Type] Article
COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial SepsisArticle Published on 2020-09-142023-07-02 Journal: Journal of Korean medical science [Category] SARS, [키워드] Cytokines Inflammation S100A9 SARS-CoV-2 [DOI] 10.3346/jkms.2020.35.e343 PMC 바로가기
COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism/Prophylactic and Therapeutic ManagementCOVID-19 감염: 바이러스성 거대혈관 및 미세혈관 응고증 및 혈전색전증/예방 및 치료 관리Review Published on 2020-09-142022-09-10 Journal: Journal of Cardiovascular Pharmacology and Therape [Category] SARS, 바이오마커, [키워드] absence alveolar damage Angiogenesis angiopathy appear Arterial thrombosis arteries Autopsies Autopsy Biomarker Biomarkers Blood blood stasis Clinical course Clinical practice Coagulation Coagulopathy Consensus COVID-19 COVID-19 patient COVID-19 patients Critically ill D-dimer Deep venous thrombosis diagnostic Embolism Endothelial dysfunction highest hospitalized patient hospitalized patients immuno-inflammatory Infarction Inflammation inflammatory state Inpatient intensive care intensive care unit lung parenchyma macro mechanism meta-analyses Meta-analysis occlusive occur Patient platelet activation Prevalence prognostic pulmonary arterial thrombosis pulmonary arteries pulmonary artery Pulmonary embolism raise reported resulting risk SARS-CoV-2 subsequent suggested Thromboprophylaxis thrombosis thrombotic thrombotic complication Thrombotic complications thrombotic occlusion Treatment Vascular Venous Thromboembolism Venous thrombosis Viral [DOI] 10.1177/1074248420958973 PMC 바로가기 [Article Type] Review
Curcumin, a traditional spice component, can hold the promise against COVID-19?Article Published on 2020-09-122023-07-01 Journal: European journal of pharmacology [Category] SARS, [키워드] COVID-19 Curcumin Cytokine storm Inflammation Molecular targets [DOI] 10.1016/j.ejphar.2020.173551 PMC 바로가기
Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes단핵구 감소증, 단핵구 형태 이상 및 과염증은 제2형 당뇨병에서 중증 COVID-19의 특징입니다Observational Study Published on 2020-09-112022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상, [키워드] COVID‐19 SARS‐CoV-2 aetiology Affect aggravate Anomaly Care Cell change changes in circulating classical Cohort condition contribute COVID diabetes Diabetic disease course Evidence expression gene expression profile group hospitalised hyperinflammation Hyperinflammatory identifying IL 6 Immune cell immune cells immune response immune responses immunology immunophenotype Increased increased expression Inflammation Inflammatory Inflammatory marker inflammatory markers intensive care interferon leucocyte lymphocyte Lymphocytes lymphocytopenia metabolism Microbiology, Virology & Host Pathogen Interaction mitigate monocyte Monocytes monocytopenia Morphological morphology Mortality observational study pandemic pathway Patient patients peripheral circulation personalised Population precision therapy quantified risk factor severe disease severity T2D target therapeutic target type 1 interferon type 2 diabete type 2 diabetes Variation variations [DOI] 10.15252/emmm.202013038 PMC 바로가기 [Article Type] Observational Study